CURRICULUM VITAE
NAME:
Robert K.S. Wong

PRESENT POSITION:
Professor and Chair, Department of Physiology and Pharmacology
Professor, Department of Neurology
State University of New York Downstate Medical Center, Brooklyn, NY 11203

EDUCATION AND TRAINING:
1975 - 1979 Postdoctoral Fellow Stanford University, Stanford, CA 1970 - 1975 Ph.D. Physiology University of Alberta, Canada 1966 - 1970 B.Sc. Physiology McGill University, Montreal, Canada

PROFESSIONAL EXPERIENCE:
Feb. 98 - present Professor and Chair, Department of Physiology & Pharmacology Professor, Department of Neurology SUNY Downstate Medical Center (aka SUNY HSCB) Brooklyn, NY
July 90 - Jan. 98 Professor and Chair, Department of Pharmacology Professor, Department of Neurology SUNY Health Science Center at Brooklyn (HSCB) Brooklyn, NY
Aug. 86 - July 90 Professor, Department of Neurology Professor, Department of Physiology and Biophysics Member, Center for Neurobiology and Behavior College of Physicians and Surgeons, Columbia University New York, NY
Sept. 83 - July 86 Associate Professor, Department of Physiology and Biophysics University of Texas Medical Branch (UTMB) at Galveston Galveston, TX
Sept. 81 - Aug. 83 Assistant Professor, Department of Physiology and Biophysics University of Texas Medical Branch (UTMB) at Galveston Galveston, TX
June 79 - Aug. 81 Assistant Professor, Department of Physiology and Biophysics Louisiana State University (LSU) Medical Center Schreveport, LA
Jan. 77 - May 79 Postdoctoral Research Associate, Department of Neurology Stanford University, Stanford, CA
Sept. 75 - Jan. 77 Postdoctoral Fellow, Department of Surgery Stanford University, Stanford, CA
Sept. 70 - Aug. 75 Graduate Teaching Assistant, Department of Physiology University of Alberta, Edmonton, Canada

RESEARCH SUPPORT:
May 1980-April 1983 Klingenstein Fellowship in Neuroscience
July 1980-June 1981 NIH R01 NS16606. Studies on Mammalian Nerve Cells
July 1981-June 1986 NIH R01 NS18464. Studies on Mammalian Nerve Cells
July 1982-June 1984 American Heart Association. Cellular Organization of the Tractus Solitaris
Nov 1983-Oct 1986 NIH P01 NS13778. Stochastic and Kinetic Process in Membrane Function. (Program Project Director: Harvey Fishman) P.I. on sub-project: Ionic Conductances in Mammalian Cortical Neurons
March 1985-Feb 1986 Epilepsy Foundation of America. Transmitter Modulation of Cortical Neurons
July 1986-June 1996 NIH R01 NS24519. Studies on Mammalian Nerve Cells (Javits Award in Neuroscience 1989-1996)
April 1987-March 1995 NIH R01 NS24682. Membrane Properties of Cortical Neurons
July 1996-June 2000 NIH R01 NS24519. Physiology of the Inhibitory Neuronal Circuit
March 2004-present FRAXA Foundation. Metabotropic glutamate receptors in Fragile X Syndrome
Sept 1997-Aug 2007 NIH R01 NS35481. Glutamate Receptors and Epilepsy

OUTSIDE SERVICE FUNCTIONS:
Member, Study Section NLS2, National Institutes of Health (1981-1990)
Co-organizer, Spring Hippocampal/Epilepsy Research Annual Meeting (1985-present)
Member, Selection Committee for Fellowship Award in Pediatric Epilepsy research, American Epilepsy Society (1989-1992)
Ad hoc Reviewer, Neuroscience Center Grant, National Institute of Alcohol and Drug Abuse (1991)
Member, Neurology Program Project B Review Group, National Institutes of Health (1993-2001)
External reviewer, Neuroscience Program, National Science Academy, Taipei, Taiwan (1997)
Member, Research Recognition Awards Committee, American Epilepsy Society (1998-2001)
Member, Investigator’s Workshop Committee, American Epilepsy Society (2001-present)
Ad hoc Reviewer, Study Section CNBT2, National Institutes of Health (2003)
Ad hoc Reviewer, Study Section CNNT2, National Institutes of Health (2003)
Co-Chair, meeting entitled At the Crossroads: Common Pathways in Fragile X and Autism, sponsored by the FRAXA Foundation, NIMH, NICHD and NINDS (2004)
Member, Editorial Boards for Epilepsy Advances in Clinical and Experimental Research, Epilepsy Research, Hippocampus, and Journal of Neuroscience Methods
Ad hoc referee for the Department of Veterans Affairs Career Development Grant Program

THESIS ADVISOR FOR THE FOLLOWING GRADUATE STUDENTS:
Riccardo Bianchi, Qiang X. Chen, Xie Chen, Shih-Chieh (Abraham) Chuang, Deng Jing, Randy E. Numann, Katherine L. Perkins, Gregory W. Taylor, Min Wang, Debra J. Watkins, Wangfa Zhao

MENTOR FOR THE FOLLOWING NIH K08 (“Mentored Clinical Scientist Development Award”) AWARDEES:
Larry S. Benardo, Jane Chan, Lisa R. Merlin, Stephen Rayport, Todd C. Sacktor

POSTDOCTORAL FELLOWS:
Julia A. Aram, James J. Celentano, Shouhui Fan, Alan Kay, Daesoo Kim, Hillary B. Michelson, Richard Miles, Carl Scheffey, Armin Stelzer, Mark Stewart, Scott M. Thompson, Riccardo Bianchi, Steven R. Young

UNIVERSITY SERVICE:
Member, Teaching Committee on Medical Physiology, UTMB Galveston
Member, Curriculum Committee in Graduate Program, UTMB Galveston
Member, Executive Committee, Department of Physiology and Cellular Biophysics, Columbia University
Member, Executive Committee, Center for Neurobiology and Behaviour, Columbia University
Applicant Interviewer, College of Medicine, Graduate School, and MD-PhD Programs, SUNY HSCB (1990-present)
Judge, Annual Graduate Student and Resident Research Competition, SUNY HSCB (1992-present)
Chair, Faculty Research Advisory Committee, SUNY HSCB (1994-1997)
Member, Search Committee for Chair of the Department of Pathology, SUNY HSCB (1995-1996)
Member, Self-Study Task Force, LCME Survey (1997)
Member, Committee on Academic and Professional Qualifications (1999-2002)
Member, Neuroscience Task Force, SUNY HSCB (2000-2001)
Member, Neural and Behavioral Science Steering Committee, SUNY HSCB (2001-present)
Member, Search Committee for Chair of the Department of Medicine, SUNY HSCB (2003-present)
Member, Search Committee for Chair of the Department of Neurology, SUNY HSCB (2003-present)
Member, LCME Survey Task Force, SUNY HSCB (2004-present)
Member, LCME Survey Research Committee, SUNY HSCB (2004-present)
Member, LCME Survey Finance Committee, SUNY HSCB (2004-present)

TEACHING EXPERIENCE:
Lecturer in neurophysiology, Physiology course (MS1), LSU
Lecturer in neurophysiology, Physiology course (MS1), UTMB Galveston
Lecturer in neurophysiology, Physiology course (MS1), Columbia University
Director, Pharmacology Graduate Program, SUNY HSCB
Block Director and Lecturer, Respiratory Physiology (MS1), SUNY HSCB
Facilitator, Case-Based Learning, Respiratory Physiology (MS1), SUNY HSCB

AWARDS AND HONORS:
University Scholar - McGill University, 1968-1970
Klingenstein Fellow in Neuroscience, 1979-1981
Jacob Javits Award in Neuroscience (NIH NINDS), 1989-1996
American Epilepsy Society Basic Scientist Award (Milken Foundation), 1998

INVITED LECTURES (selected):
Satellite Symposium on the Physiology and Pharmacology of Epileptic Phenomena, 28th International Congress of Physiological Sciences (1981)
Symposium on GABAergic Neurones in Information Processing, Basic and Clinical Aspects, held at Rinberg Castle, Bavaria, organized by R.A. Diesz and D. Lux, Max-Planck-Institute. FRG (1982)
International Symposium on Basic Mechanisms of the Epilepsies, held in San Diego, CA, organized by A. Delgado-Escueta, A.A. Ward, D.M. Woodbury and R.J. Porter (1983)
Symposium on Neural Mechanisms of Conditioning, held at Woods Hole, organized by D. Alkon and C.D. Woody (1983)
Meeting entitled Mechanisms of Integration in the Nervous System, held at Wakula Springs, FL, organized by M. Burrow, and Company of Biologists, Univ. of Cambridge, U.K. (1984)
Grass Travelling Scientist to Vancouver B.C. Chapter of the Society for Neuroscience (1984)
Symposium on Excitatory Amino-acids and Epilepsy, held at Fillerval, France, organized by R. Schwarz and Y. Ben Ari (1985)
Symposium on Epilepsy and Calcium, held at Munster, FDR, organized by E.J. Speckmann (1985)
Satellite Symposium on the Cellular Mechanisms of Conditioning and Behavioral Plasticity, International Congress of Physiological Sciences, held in Seattle, WA., organized by D. Alkon, C. Woody and W. Crill (1986)
Satellite Symposium on Synaptic Plasticity in the Hippocampus, International Brain Research Organization (IBRO) Congress, held at Pecs, Hungary, organized by G. Buzaki and H. Haas (1987)
Satellite Symposium on Physiology and Pharmacology of Epilepsies, International Congress of Physiological Sciences, held at Frankfurt, FRG (1989)
6th Capo Boi Conference on Neuroscience, held at Villasimius, Sardinia, Italy (1989)
Grass Travelling Scientist to Calgary Chapter of Society for Neuroscience, “Synaptic plasticity in the hippocampus” (1989)
Investigator’s Workshop, American Epilepsy Society Annual Meeting (1989)
Public Lecture Series, Society for Neuroscience Annual Meeting (1990)
Symposium on Transmitter Amino Acid Receptors: Structure, Transduction and Models for Drug Development, Fidia Research Foundation (1991).
Short Course, Society for Neuroscience Annual Meeting (1992)
Investigator’s Workshop, American Epilepsy Society Annual Meeting (1992)
Investigator’s Workshop, American Epilepsy Society Annual Meeting (1993)
Investigator’s Workshop, American Epilepsy Society Annual Meeting (1994)
Neuroscience lecture series, New York Medical College (1995)
Third International Symposium on Basic Mechanisms of the Epilepsies, held in San Diego, CA, organized by AV Delgado-Escueta, WA Wilson, RW Olsen, & RJ Porter (1996)
Investigator’s Workshop, American Epilepsy Society Annual Meeting (1996)
International School Organized by International Brain Research Organization (IBRO) (2002)
Banbury Conference on Synaptic Function in Fragile X, Cold Spring Harbor, NY (2003)
Plenary Speaker, Korean Neuroscience Society Annual Meeting (2003)
Banbury Conference on Mechanisms Underlying Fragile X, Cold Spring Harbor, NY (2004)
Meeting on Fragile X and Autism, sponsored by the FRAXA Research Foundation and NIH, Newport, RI (2004)
Investigator’s Workshop, American Epilepsy Society Annual Meeting (2004)

SPECIFIC RESEARCH INTERESTS:
Intra- and intercellular signal transduction in the cortex.
Synaptic plasticity in the cortex.
Basic mechanisms of epilepsy.
Biophysical properties of voltage- and ligand-gated channels.

BOOK CHAPTERS:
Wong R.K.S. & Schwartzkroin P.A. Pacemaker neurons in the mammalian brain: mechanisms and function. In: Cellular Pacemakers. D.O. Carpenter, Ed., John Wiley & Sons, Inc.: New York, pp. 237-254 (1982).
Wong R.K.S. Postsynaptic potentiation mechanism in the hippocampal pyramidal cells. In: Physiology and Pharmacology of Epileptogenic Phenomena. M.R. Klee, H.D. Lux & E.-J. Speckmann, Eds., Raven Press: New York, pp. 163-174 (1982).
Wong R.K.S., Traub R.D. & Miles R. Epiletogenic mechanisms as revealed by studies of hippocampal slice. In: Electrophysiology of Epilepsy. P.A. Schwartzkroin & H.V. Wheal, Eds., Academic Press: London, pp. 253-275 (1984).
Wong R.K.S., Numann R.E., Miles R. & Traub R.D. Hippocampal pyramidal cells: Ionic conductance and synaptic interactions. In: Neuronal Mechanisms of Conditioning. D.L. Alkon & C.D. Woody, Eds., Plenum Press: New York, pp. 311-318 (1985).
Wong R.K.S., Traub R.D. & Miles, R. Cellular basis of neuronal synchrony in epilepsy. In: Basic Mechanisms of the Epilepsies: Molecular and Cellular Appoaches. A.V. Delgado-Escueta, A.A. Ward, D.M. Woodbury, and R.J. Porter, Eds., Raven Press: New York, pp. 583-592 (1986).
Traub R.D., Wong R.K.S. & Miles R. In vitro models of epilepsy. In: Neurotransmitters and Epilepsy. P.C. Jobe and H.E. Laird II, Eds., Humana Press: Clifton, pp. 161-190 (1987).
Miles R., Wong R.K.S. & Traub R.D. Recurrent excitatory synapses between CA3 neurones in the hippocampus. In: Excitatory Amino Acids and Synaptic Transmission. H. Wheal and A. Thompson, Eds., Academic Press: London, pp.141-154 (1991).
Wong R.K.S. & Michelson H.B. Novel features of GABAA receptor function in the hippocampus. In: Transmitter Amino Acid Receptors: Structures, Transduction and Models for Drug Development. FIDIA Research Foundation Symposium Series, Vol. 6, E.A. Barnard and E. Costa, Eds., Thieme Medical Publishers: New York (1991).
Benardo L.S. & Wong R.K.S. Inhibition in the cortical network. In: The Cortical Neuron. I. Mody and M.J. Gutnick, Eds., Oxford University Press: New York, pp. 141-155 (1995).
Wong R.K.S., Bianchi R., Taylor G.W. & Merlin L.R. Role of metabotropic glutamate receptors in epilepsy. In: Jasper's Basic Mechanisms of the Epilepsies, 3rd edition. A.V. Delgado-Escueta, W.A. Wilson, R.W. Olsen, and R.J. Porter, Eds., Lippincott-Raven: Philadelphia, pp. 685-698 (1999).
Wong R.K.S., Bianchi R., & Chuang S-C. Plasticity mechanisms underlying mGluR-induced epileptogenesis. In: Recent Advances in Epilepsy Research. D.K. Binder and H.E. Scharfman, Eds., Kluwer Academic/Plenum Publishers: New York (2004)

PUBLICATIONS (Abstracts not listed):
Wong R.K.S. & Pearson K.G. Limitations on impulse conduction in the terminal branches of insect sensory nerve fibers. Brain Res. 100: 431-436 (1975).
Wong R.K.S. & Pearson K.G. Properties of the trochanteral hair plate and its function in the control of walking in the cockroach. J. Exp. Biol. 64: 233-249 (1976).
Pearson K.G., Wong R.K.S. & Fourtner, C.R. Connexions between hairplate afferents and motoneurones in the cockroach leg. J. Exp. Biol. 64: 251-266 (1976).
French A.S. & Wong R.K.S. Response of the hairplate to random and sinusoidal stimulus. Biol. Cybern. 22: 33 (1976).
French A.S. & Wong R.K.S. Nonlinear analysis of sensory transduction in an insect mechanoreceptor. Biol. Cybern. 26: 231-240 (1977).
Klyce S.D. & Wong R.K.S. Site and mode of adrenaline action on chloride transport across the rabbit corneal epithelium. J. Physiol. 266: 777-799 (1977).
Wong R.K.S. & Prince D.A. Participation of calcium spikes during intrinsic burst firing in hippocampal neurons. Brain Res. 159: 385-390 (1978).
Wong R.K.S., Prince D.A. & Basbaum A.I. Intradendritic recordings in the hippocampal neurons. Proc. Natl. Acad. Sci. (USA) 76: 986-990 (1979).
Wong R.K.S. & Prince D.A. Dendritic mechanisms underlying penicillin induced epileptiform activity. Science 204: 1228-1231 (1979).
Brown T.H., Wong R.K.S. & Prince D.A. Spontaneous miniature synaptic potentials in hippocampal neurons. Brain Res. 177: 194-199 (1979).
Wong R.K.S. & Prince D.A. Afterpotential generation in hippocampal pyramidal cell. J. Neurophysiol. 45: 86-97 (1981).
Traub R.D. & Wong R.K.S. Penicillin-induced epileptiform activity in the hippocampal slice: a model of synchronization of CA3 pyramidal cell bursting. Neuroscience 6: 223-230 (1981).
Prince D.A. & Wong R.K.S. Human epileptic neurons studied in vitro. Brain Res. 210: 323-333 (1981).
Wong R.K.S. & Watkins D.J. Cellular factors influencing GABA response in hippocampal pyramidal cells. J. Neurophysiol. 48: 938-951 (1982).
Traub R.D. & Wong R.K.S. Cellular mechanism of neuronal synchronization in epilepsy. Science 216: 745-747 (1982).
Wong R.K.S. & Traub R.D. Synchronized burst discharge in disinhibited hippocampal slice. I. Initiation in CA2-CA3 region. J. Neurophysiol. 49: 442-458 (1983).
Traub R.D. & Wong, R.K.S. Synchronized burst discharge in disinhibited hippocampal slice. II. Model of cellular mechanism. J. Neurophysiol. 49: 459-471 (1983).
Traub R.D. & Wong R.K.S. Synaptic mechanisms underlying interictal spike initiation in a hippocampal network. Neurology 33: 257-266 (1983).
Miles R. & Wong R.K.S. Single neurones can initiate synchronized population discharge in the hippocampus. Nature 306: 371-373 (1983).
Miles R., Wong R.K.S. & Traub R.D. Synchronized afterdischarges in the hippocampus: contribution of local synaptic interactions. Neuroscience 12: 1179-1189 (1984).
Traub R.D., Knowles W.D., Miles, R. & Wong R.K.S. Synchronized afterdischarges in the hippocampus: simulation studies of the cellular mechanism. Neuroscience 12: 1191-1200 (1984).
Miles R. & Wong R.K.S. Unitary inhibitory synaptic potentials in the guinea-pig hippocampus in vitro. J. Physiol. 356: 97-113 (1984).
Wong R.K.S., Miles R. & Traub R.D. Local circuit interactions in synchronization of cortical neurones. J. Exp. Biol. 112: 169-178 (1984).
Numann R.E. & Wong R.K.S. Voltage-clamp study on GABA response desensitization in single pyramidal cells dissociated from the hippocampus of adult guinea pigs. Neurosci. Lett. 47: 289-294 (1984).
McIntyre D.C. & Wong R.K.S. Modification of local neuronal interactions by amygdala kindling examined in vitro. Exp. Neurol. 88: 529-537 (1985).
Wong R.K.S., Traub R.D. & Miles R. Signal integration in the cortex. Prog. Clin. Biol. Res. 176: 335-342 (1985).
Knowles W.D., Traub R.D., Wong R.K.S. & Miles R. System properties of neural networks revealed by experimentation and modelling of the epileptic hippocampal slice. Trends Neurosci. 8: 73-79 (1985).
Traub R.D., Wong R.K.S., Miles R. & Knowles W.D. Neuronal interactions during epileptic events in vitro. Fed. Proc. 44: 2953-2955 (1985).
Miles R. & Wong R.K.S. Excitatory synaptic interactions between CA3 neurons in the guinea pig hippocampus in vitro. J. Physiol. 373: 397-418 (1986).
Wong R.K.S., Traub R.D. & Miles R. Cellular basis of neuronal synchrony in epilepsy. Adv. Neurol. 44: 583-592 (1986).
McIntyre D.C. & Wong R.K.S. Cellular and synaptic properties of amygdala-kindled pyriform cortex in vitro. J. Neurophysiol. 55: 1295-1307 (1986).
Kay A.R. & Wong R.K.S. Isolation of neurons suitable for patch-clamping from adult mammalian central nervous system. J. Neurosci. Methods 16: 227-238 (1986).
Kay A.R., Miles R. & Wong R.K.S. Intracellular fluoride alters the kinetic properties of calcium currents facilitating the investigation of synaptic events in hippocampal neurons. J. Neurosci. 6: 2915-2920 (1986).
Numann R.E., Wadman W.J. & Wong R.K.S. Outward currents of single hippocampal cells obtained from the adult guinea-pig. J. Physiol. 393: 331-353 (1987).
Kay A.R. & Wong R.K.S. Calcium current activation kinetics in isolated pyramidal neurones of the CA1 region of the mature guinea-pig hippocampus. J. Physiol. 392: 603-616 (1987).
Miles R. & Wong R.K.S. Inhibitory control of local excitatory circuits in the guinea-pig hippocampus. J. Physiol. 388: 611-629 (1987).
Traub R.D., Knowles W.D., Miles R. & Wong R.K.S. Models of the cellular mechanism underlying propagation of epileptiform activity in the CA2-CA3 region of the hippocampal slice. Neuroscience 21: 457-470 (1987).
Traub R.D., Miles R. & Wong R.K.S. Models of synchronized hippocampal bursts in the presence of inhibition. I. Single population events. J. Neurophysiol. 58: 739-751 (1987).
Traub R.D., Miles R., Wong R.K.S., Schulman L.S. & Schneiderman J.H. Models of synchronized hippocampal bursts in the presence of inhibition. II. Ongoing spontaneous population events. J. Neurophysiol. 58: 752-764 (1987).
Miles R. & Wong R.K.S. Latent synaptic pathways revealed after tetanic stimulation in the hippocampus. Nature 329: 724-726 (1987).
Connor J.A., Wadman W.J., Hockberger P.E. & Wong R.K.S. Sustained dendritic gradients of Ca2+ induced by excitatory amino acids in hippocampal neurons. Science 240: 649-653 (1988).
Stelzer A., Kay A. & Wong R.K.S. GABAA-receptor function in hippocampal cells is maintained by phosphorylation factors. Science 241: 339-341 (1988).
Miles R., Traub R.D. & Wong R.K.S. Spread of synchronous firing in longitudinal slices from the CA3 region of the hippocampus. J. Neurophysiol. 60: 1481-1496 (1988).
Traub R.D., Miles R. & Wong R.K.S. Large scale simulations of the hippocampus. IEEE Engineering in Medicine & Biology 6: 31-38 (1988).
Buzsaki G., Bayardo F., Miles R., Wong R.K.S. & Gage F.H. The grafted hippocampus: an epileptic focus. Exp. Neurol. 105: 10-22 (1989).
Traub R.D., Miles R. & Wong R.K.S. Model of the origin of rhythmic population oscillations in the hippocampal slice. Science 243: 1319-1325 (1989).
Stelzer A. & Wong R.K.S. GABAA responses in hippocampal neurons are potentiated by glutamate. Nature 337: 170-173 (1989).
Chen Q.X., Stelzer A., Kay A.R., & Wong R.K.S. GABAA receptor function is regulated by phosphorylation in acutely dissociated guniea-pig hippocampal neurones. J. Physiol. 420: 207-221 (1990).
Chen Q.X. & Wong R.K.S. Intracellular Ca2+ suppressed a transient potassium current in hippocampal neurons. J. Neurosci. 11: 337-343 (1991).
Aram J.A., Michelson H.B. & Wong R.K.S. Synchronized GABAergic IPSPs recorded in the neocortex after blockade of synaptic transmission mediated by excitatory amino acids. J. Neurophysiol. 65: 1034-1041 (1991).
Traub R.D., Wong R.K.S., Miles R. & Michelson H.B. A model of a CA3 hippocampal neuron incorporating voltage-clamp data on intrinsic conductances. J. Neurophysiol. 66: 635-650 (1991).
Michelson H.B. & Wong R.K.S. Excitatory synaptic responses mediated by GABAA receptors in the hippocampus. Science 253: 1420-1423 (1991).
Thompson S.M. & Wong R.K.S. Development of calcium current subtypes in isolated rat hippocampal pyramidal cells. J. Physiol. 439: 671-689 (1991).
Wong, R.K.S. Current topics on GABA mediated inhibition in the hippocampus. Soc. Neurosci.: Short Course Syllabus (1992).
Chen Q.X. & Wong R.K.S. Different effects of intracellular and extracellular TEA on voltage-dependent K currents of acutely isolated hippocampal CA1 neurons. Brain Res. 582: 232-236 (1992).
Wong R.K.S. & Stewart M. Different firing patterns generated in dendrites and somata of CA1 pyramidal neurons in guinea-pig hippocampus. J. Physiol. 457: 675-687 (1992).
Stewart M. & Wong R.K.S. Intrinsic properties and evoked responses of guinea pig subicular neurons in vitro. J. Neurophysiol. 70: 232-245 (1993).
Merlin L.R. & Wong R.K.S. Synaptic modifications accompanying epileptogenesis in vitro: long-term depression of GABA-mediated inhibition. Brain Res. 627: 330-340 (1993).
Celentano J.J. & Wong R.K.S. Multiphasic desensitization of the GABAA receptor in outside-out patches. Biophys. J. 66: 1039-1050 (1994).
Michelson H.B. & Wong R.K.S. Synchronization of inhibitory neurones in the guinea-pig hippocampus in vitro. J. Physiol. 477: 35-45 (1994).
Dun N.J., Dun S.L., Wong R.K.S. & Forstermann U. Co-localization of nitric oxide synthase- and somatostatin-immunoreactivity in rat dentate hilar neurons. Proc. Natl. Acad. Sci. (USA) 91: 2955-2959 (1994).
Fan S., Stewart M. & Wong R.K.S. Differences in voltage-dependent sodium currents exhibited by superficial and deep layer neurons of guinea-pig entorhinal cortex. J. Neurophysiol. 71: 1986-1991 (1994).
Bianchi R. & Wong R.K.S. Carbachol-induced synchronized rhythmic bursts in CA3 neurons of guinea pig hippocampus in vitro. J. Neurophysiol. 72: 131-138 (1994).
Chen Q.X. & Wong R.K.S. Intracellular control of GABAA-receptor responses in hippocampal neurons: role of phosphorylation. Jpn. J. Physiol. 44 Suppl 2: S101-S104 (1994).
Chen Q.X. & Wong R.K.S. Suppression of a Ca2+ current by NMDA and intracellular Ca2+ in acutely isolated hippocampal neurons. J. Neurophysiol. 73: 515-524 (1995).
Chen Q.X. & Wong R.K.S. Suppression of GABAA receptor responses by NMDA application in hippocampal neurones acutely isolated from the adult guinea-pig. J. Physiol. 482: 353-362 (1995).
Stewart M. & Wong R.K.S. A method allowing intracellular and extracellular single-unit recordings from brain slices in the grease-gap chamber. J. Neurosci. Methods 58: 17-24 (1995).
Perkins K.L. & Wong R.K.S. Intracellular QX-314 blocks the hyperpolarization-activated inward current Iq in hippocampal CA1 pyramidal cells. J. Neurophysiol. 73: 911-915 (1995).
Merlin L.R., Taylor G.W. & Wong R.K.S. Role of metabotropic glutamate receptor subtypes in the patterning of epileptiform activities in vitro. J. Neurophysiol. 74: 896-900 (1995).
Taylor G.W., Merlin L.R. & Wong R.K.S. Synchronized oscillations in hippocampal CA3 neurons induced by metabotropic glutamate receptor activation. J. Neurosci. 15: 8039-8052 (1995).
Bianchi R. & Wong R.K.S. Excitatory synaptic potentials dependent on metabotropic glutamate receptor activation in guinea-pig hippocampal pyramidal cells. J. Physiol. 487: 663-676 (1995).
Zhang A., Fan S.H., Cheng T.P., Altura B.T., Wong R.K.S. & Altura B.M. Extracellular Mg2+ modulates intracellular Ca2+ in acutely isolated hippocampal CA1 pyramidal cells of the guinea-pig. Brain Res. 728: 204-208 (1996).
Perkins K.L. & Wong R.K.S. Ionic basis of the postsynaptic depolarizing GABA response in hippocampal pyramidal cells. J. Neurophysiol. 76: 3886-3894 (1996).
Fan S. & Wong R.K.S. Selective expression of trasient outward current in different types of acutely isolated hippocampal interneurons. J. Neurophysiol. 76: 3563-3567 (1996).
Chen Q.X., Perkins K.L., Choi D.W. & Wong R.K.S. Secondary activation of a cation conductance is responsible for NMDA toxicity in acutely isolated hippocampal neurons. J. Neurosci. 17: 4032-4036 (1997).
Perkins K.L. & Wong R.K.S. The depolarizing GABA response. Can. J. Physiol. Pharmacol. 75: 516-519 (1997).
Merlin L.R. & Wong R.K.S. Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro. J. Neurophysiol. 78: 539-544 (1997).
Chen Q.X., Perkins K.L. & Wong R.K.S. Zn2+ blocks the NMDA- and Ca2+-triggered postexposure current Ipe in hippocampal pyramidal cells. J. Neurophysiol. 79: 1124-1126 (1998).
Merlin L.R., Bergold P.J. & Wong R.K.S. Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform discharges. J. Neurophysiol. 80: 989-993 (1998).
Wong R.K.S., Bianchi R., Taylor G.W. & Merlin L.R. Role of metabotropic glutamate receptors in epilepsy. Adv. Neurol. 79: 685-698 (1999).
Bianchi R., Young S.R. & Wong R.K.S. Group I mGluR activation causes voltage-dependent and -independent Ca2+ rises in hippocampal pyramidal cells. J. Neurophysiol. 81: 2903-2913 (1999).
Chuang S-C., Bianchi R. & Wong R.K.S. Group I mGluR activation turns on a voltage-gated inward current in hippocampal pyramidal cells. J. Neurophysiol. 83: 2844-2853 (2000).
Young S.R., Wong R.K.S. & Bianchi R. Simultaneous intracellular recording and calcium imaging in single neurons of hippocampal slices. Methods 21: 373-383 (2000).
Chuang S-C., Bianchi R., Kim D., Shin H.S. & Wong R.K.S. Group I metabotropic glutamate receptors elicit epileptiform discharges in the hippocampus through PLCβ1 signaling. J. Neurosci. 21: 6387-6394 (2001).
Chuang S-C., Zhao W., Young S.R., Conquet F., Bianchi R. & Wong R.K.S. Activation of group I mGluRs elicits different responses in murine CA1 and CA3 pyramidal cells. J. Physiol. 541: 113-121 (2002).
Lee A.C., Wong R.K.S., Chuang S-C., Shin H.S. & Bianchi R. Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. J. Neurophysiol. 88: 1625-1633 (2002).
Wong R.K.S., Chuang, S-C. & Bianchi R. Metabotropic glutamate receptors and epileptogenesis. Epilepsy Currents 2: 81-85 (2002).
Zhao W., Bianchi R., Wang M. & Wong R.K.S. Extracellular signal-regulated kinase 1/2 is required for the induction of group I mGluR-mediated epileptiform discharges. J. Neurosci. 24: 76-84 (2004).
Young S.R., Chuang S-C. & Wong R.K.S. Modulation of afterpotentials and firing pattern in guinea pig CA3 neurones by group I metabotropic glutamate receptors. J. Physiol. 554: 371-385 (2004).