CURRICULUM VITAE

PERSONAL David Landreth Van Vactor, Jr.; U.S. Citizen SSN 027-54-1520
Department of Cell Biology (617)-432-2195 Office
Program in Neuroscience (617)-432-2196/4609 Lab
Harvard Medical School, LHRRB-401A (617)-432-1144 FAX
240 Longwood Avenue Davie@hms.harvard.edu
Boston, MA 02115-5730 http://cellbio.med.harvard.edu/faculty/van_vactor/

EDUCATION
1981-1985 B.A., Behavioral Biology,
The Johns Hopkins University, Baltimore, MD.
1987 Neurobiology Course,
Marine Biology Laboratory, Wood's Hole, MA.
1985-1991 Ph.D., Department of Biological Chemistry,
University of California, Los Angeles, CA.

FELLOWSHIPS & AWARDS
1987 Kugel Fellowship, Office of the Dean, UCLA School of Medicine.
1987 MBL Neurobiology Scholarship, Society of General Physiologists.
1987 UCLA Graduate Division Professional/Scholarly Travel Grant.
1990-1992 NIMH/NRSA Predoctoral Research Grant.
1991-1994 American Cancer Society Postdoctoral Fellowship (National Division).
1994-1996 American Cancer Society Senior Postdoctoral Fellowship (California Division).
1996-1999 Klingenstein Fellowship in the Neurosciences, The Esther A. and Joseph Klingenstein Fund, Inc.
1997-1999 New Investigator Award, Harcourt General Charitable Foundation, Inc.
1997-2000 McKnight Scholar Award, The McKnight Endowment Fund for Neuroscience.
1999 William S. Edgerly Science Partnership Fund Award, Massachusetts Institute of Technology, School of Science.
2000-2005 Scholar Award, The Leukemia and Lymphoma Society.
2003 The Dean’s Community Service Award, Harvard Medical School.

PROFESSIONAL EXPERIENCE
1986-1991 Graduate Thesis at U.C.L.A. School of Medicine. Advisor: Dr. S. Lawrence Zipursky.
Topic: Control of Cell Fate and Morphogenesis in the Drosophila Compound Eye.
1991-1995 Postdoctoral Research at U.C. Berkeley. Advisor: Dr. Corey S. Goodman.
Topic: Mechanisms that Control Neuromuscular Specificity in the Drosophila Embryo.
1995-2001 Assistant Professor in the Department of Cell Biology at Harvard Medical School.
1995-present Member of the Program in Neuroscience at Harvard Medical School.
2000- present Member of the Dana Farber/Harvard Cancer Center.
2001- present Associate Professor in the Department of Cell Biology at Harvard Medical School.
2002-present Member, Harvard Center for Neurodegeneration and Repair.

TEACHING EXPERIENCE
1996-present Director, Basic Science Partnership, genetics for high school students.
1997, 98 Lecturer in Cell Biology & Biological Chemistry 201, graduate core course.
1997, 99, 01, 02 Lecturer & Discussion leader in Developmental Neurobiology 207, graduate core course.
1998, 99 Course director, Advanced Topics in Developmental Neurobiology, 300-level graduate course.
1998, 99, 00 Faculty, Neurobiology Course, Marine Biology Laboratories, Woods Hole, MA.
2001 Lecturer & Discussion leader in Developmental Biology & Genetics CB214, Adv. grad. course.
2002, 03, 04 Co-director, Neurobiology of Drosophila Course, Cold Spring Harbor Laboratories, NY.
2003 Course director, Developmental Biology & Genetics CB214, adv. graduate course.
2004 Discussion leader, Cell Biology 201, graduate core course.
SOCIETY MEMBERSHIP
American Society for Cell Biology
Genetics Society of America
Society for Neuroscience
Society for Developmental Biology

MEETING ORGANIZATION/SUPPORT
2003 Session chair: Northeast Regional Society for Developmental Biology Meeting, Woods Hole, MA.
2003 Session chair: Neurobiology of Drosophila Meeting, Cold Spring Harbor Laboratories, Cold Spring
Harbor, NY.
2003 Co-chair, Minisymposium: “Neuronal Pathfinding and Diseases” Annual Meeting of the American
Society for Cell Biology, San Francisco, CA.
2003, 04, 05 Co-organizer, “Neuronal Connections”, Symposium on Neural Development, Biogen Corp.,
Cambridge, MA.
2005 Co-organizer: Neurobiology of Drosophila Meeting, Cold Spring Harbor Laboratories, Cold Spring
Harbor, NY.

EDITORIAL BOARDS
2000-present Current Biology, Elsevier Science Ltd.
2001-present Faculty of 1000 (http://www.facultyof1000.com), Current Science Group.
2004-present Biomed Central (BMC) Neuroscience

AD HOC REVIEWING ACTIVITY
Journals: Cell, Science, Nature, Nature Neurosci., Neuron, Current Biol., Development, J. Neurosci., J. Neurobiol., EMBO J., Brain Res., J. Cell Sci., P.N.A.S., Dev. Biol., Genes & Dev., T.I.G., T.I.C.B. , Mol. & Cell. Biol.
Funding agencies: Ad Hoc Reviewer for NIH MDCN-5, MDCN-6 & ZRG1 VISC(03) study sections, NIH fellowship review, NICHD site visit panel, Spinal Cord Research Fund, National Science Foundation, Binational Science Foundation, The Welcome Trust, ND EPSCoR., Medical Research Council, NY State Dept. of Health Spinal Cord Research Fund.

INVITED PRESENTATIONS (from 1996)
Southwestern Developmental Biology Conference: Cell Interactions. Texas Women's University, Denton, TX.
Seminar: Department of Molecular Biology, Massachusetts General Hospital, Boston, MA.
Seminar: Exelixis Pharmaceuticals, Inc., Cambridge, MA.
Lecture: Neurobiology Course, Cold Spring Harbor Laboratories, NY.
EMBO Workshop: The Molecular Biology of Growth Cone Guidance. EMBL, Heidelberg, Germany.
Seminar: Department of Neuroscience, Children's Hospital, Boston, MA.
1997
Seminar: MGH Cancer Center, Massachusetts General Hospital East, Charlestown, MA.
East Coast Developmental Biology Meeting, Wood's Hole, MA.
Workshop: Signal Transduction in Neuronal Development and Recognition. Instituto Juan March de Estudios e Investigaciones, Madrid, Spain.
Seminar: Department of Neuroscience, Harvard Medical School, Boston, MA.
Seminar: Department of Biology, S.U.N.Y., Stony Brook, NY.
1998
Seminar: Department of Biochemistry, Boston University School of Medicine, Boston, MA.
Seminar: Department of Biology, University of Southern California, Los Angeles, CA.
Seminar: Molecular Biology Institute, University of California, Los Angeles, CA.
Seminar: Department of Neuroscience, The Johns Hopkins School of Medicine, Baltimore, MD.
Seminar: David Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia, PA.
Seminar: Department of Biology, Brandeis University, Waltham, MA.
Seminar: Shriver Center for Mental Retardation, Inc., Waltham, MA.
1999
Panel on Protein Tyrosine Kinases and Phosphatases in the Brain, Winter Conference on Brain Research, Snowmass, CO.
Seminar: The Spaulding Rehabilitation Hospital, Boston, MA.
Seminar: MGH Cancer Center, Massachusetts General Hospital East, Charlestown, MA.
Neuroscience Fellows Meeting, The Esther A. and Joseph Klingenstein Fund, NY.
Lecture: Developmental Neurobiology Course, Cold Spring Harbor Laboratories, NY.
EMBO Workshop: Axon Guidance and Developmental Plasticity, Varrena, Italy.
2000
Seminar: Department of Zoology, University of British Columbia, Vancouver, Canada.
Seminar: Fred Hutchinson Cancer Center, Seattle, WA.
Seminar: Neuroscience Program, U.C.S.F., San Francisco, CA.
Seminar: Division of Neuroscience, Children’s Hospital, Boston, MA.
Seminar: Department of Neuroscience, Rockefeller University, New York, NY.
Seminar: Department of Cell Biology, Case Western Reserve University, Cleveland, OH.
Symposium:13th Biennial Meeting of the International Society for Developmental Neuroscience, Heidelberg, Germany.
Seminar: Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany.
Seminar: Research Institute of Molecular Pathology (IMP), Vienna, Austria.
Seminar: Molecular Neurobiology, Guy’s Hospital, King’s College, London, U.K.
Seminar: Department of Anatomy, University of Cambridge, Cambridge, U.K.
Seminar: Center for Neurobiology and Behavior, Columbia University, New York, NY.
Seminar: Hematology Division, Brigham and Women's Hospital, Boston, MA.
Symposium: Axon Guidance-Links to the Cytoskeleton. Annual Meeting of the Society for Neuroscience,
New Orleans, LA.
The 4th International Conference on Protein Phosphatases. Sendai, Japan.
Seminar: Department of Physics, University of Tokyo, Tokyo, Japan.
Seminar: Section of Neurobiology, Yale University, New Haven, CN.
2001
Meeting: Cell and Tissue Morphogenesis. British Society of Cell Biology & British Society for Developmental Biology,
Univeristy of Sussex, Brighton, UK.
Lecture: Axon Guidance. Neurobiology of Drosophila Course. Cold Spring Harbor Labs. Cold Spring Harbor, NY.
Seminar: Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX.
Workshop: Signaling at the Growth Cone. Instituto Juan March de Estudios e Investigaciones, Madrid, Spain.
Seminar: Instituto de Neurociencias, San Juan de Alicante, Spain.
2002
Plenary talk: Keystone Symposium on Cellular Motility and Signaling in the Wiring and Plasticity of Nervous Systems,
Taos, NM.
Seminar: Department of Biological Chemistry, U.C.L.A. School of Medicine, Los Angeles, CA.
Presentation: McKnight Foundation Conference on Neuroscience, Aspen, CO.
Plenary talk: Gordon Conference "Cell Biology of the Neuron", Salve Regina College, Newport, RI.
Seminar: Department of Cell and Molecular Physiology. University of North Carolina at Chapel Hill, NC.
Seminar: Dept. of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO.
Seminar: Laboratoire d'Enzymologie et Biochimie Structurales, C.N.R.S., GIF sur YVETTE. France.
Seminar: INSERM U106, Batiment de Pediatrie, Hopital de la Salpetriere, Paris, France.
2003
Seminar: Udall Parkinson's Disease Research Centers Seminar Series, McLean Hospital Neuroscience, Waltham, MA.
Plenary Talk: Keystone Symposium on Molecular Cues for Development and Regeneration of Axonal Connections,
Keystone, CO.
Seminar: Department of Cell Biology and Development, University of Minnesota, Minneapolis, MN.
Speaker: Northeast Regional Society for Developmental Biology Meeting, Woods Hole, MA.
Seminar: Department of Biology, University of Massachusetts, Amherst, MA.
Seminar: The Rockefeller University, New York, NY.
Seminar: Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY.
Armenise-Harvard Foundation Symposium on “Environmental Sensing and the Cellular Response”, International
Centre for Theoretical Physics (ICTP), Trieste, Italy.
Lecture: Neural Development Course, Cold Spring Harbor Laboratories, Cold Spring Harbor, NY.
Speaker: “Neuronal Connections”, Symposium on Neural Development, Biogen Corp., Cambridge, MA.
Seminar: Stanford Brain Research Institute, Stanford University, Stanford, CA.
2004
Seminar: Ludwig Institute for Cancer Research, University College, London, UK.
Seminar: Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Toronto, Ontario, Canada
Speaker: FASEB Meeting on “Protein Phosphatases”, Snowmass , CO.
Seminar: Department of Biochemistry, McGill University, Montreal, Canada.
Seminar: Dept. of Molecular, Cellular and Developmental Biology, Yale University, New Haven , CT.
Symposium: "Life Sciences Forum", Chinese Academy of Sciences, Shanghai, China.
Seminar: MGHE Cancer Center, Massachusetts General Hospital, Charlestown, MA.
2005
Plenary talk: Keystone Symposium on Cell Migration and Adhesion, Snowbird, Utah.
Plenary talk: Keystone Symposium on Axonal Connections: Molecular Cues for Development and Regeneration,
Breckenridge, CO.
Seminar: the Department of Entomology, University of Maryland, College Park, MD.
Seminar: Vienna Biocenter, Vienna, Austria.

MANUSCRIPTS IN PREPARATION
1) Lorenz, L., Cao, Q., Jung, Y., Perrimon, N., Van Vactor, D. and Richter, J. Midline, an EIF4E-Binding Protein, Mediates Longitudinal Axon Guidance and Netrin Signaling. submitted.
2) Johnson, K., Rawson, J., Selleck, S., and Van Vactor, D. Syndecan and the Glypican Dallylike control distinct aspects of axon pathfinding in the Drosophila embryo. submitted.
3) Rawson, J., Johnson, K., Ge, X,, Van Vactor, D. and Selleck, S. Heparan Sulfate Proteogylcans Mediate the Guidance and Targeting of Drosophila Retinal Axons. submitted.
4) Miller, K., DeProto, J., Patel, B., Kaufmann, N. and Van Vactor, D. Drosophila Liprin- is Required for Axonal Transport of Synaptic Vesicles. submitted.
5) Johnson, K., Tenney, A., Duckworth, A., Marcu, O., Heslip, T., Marsh, L., Flanagan, J.G., and Van Vactor, D. The Proteoglycans Syndecan and Dallylike Act Antagonistally to Control Synapse Growth as Ligands of the LAR Receptor Tyrosine Phosphatase. In preparation.
6) Rusch, J., Thompson, C., Duckworth, A. and Van Vactor, D. The Abelson tyrosine kinase and Fragile-X mental retardation protein orthologues of Drosophila cooperate to control synapse growth downstream of the receptor protein tyrosine phosphatase LAR. In preparation.

RESEARCH PUBLICATIONS
1) Van Vactor, D., Krantz, D., Reinke, R., Zipursky, S.L. (1988) Analysis of Mutants in Chaoptin, a Photoreceptor Cell-Specific Glycoprotein in Drosophila, Reveals Its Role in Cellular Morphogenesis. Cell 52, 281-290.
2) Hart*, A., Krämer*, H., Van Vactor*, D., Paidhungat, M., Zipursky, S.L. (1990) Induction of Cell Fate in the Drosophila Retina: bride of sevenless is Predicted to Contain a Large Extracellular Domain and Seven Transmembrane Segments. Genes and Development 4, 1835-1847.
* These authors, in alphabetical order, contributed equally to this work.
3) Van Vactor, D.L., Cagan, R.L., Krämer, H., Zipursky, S.L. (1991) Induction in the Developing Compound Eye of Drosophila: Multiple Mechanisms Restrict R7 Induction to a Single Precursor Cell. Cell 67, 1145-1155.
4) Hart, A.C, Harrison, S.D., Van Vactor, D.L., Rubin, G.M., Zipursky, S.L. (1993) The Interaction of bride of sevenless with sevenless is Conserved Between Drosophila virilis and Drosophila melanogaster . P.N.A.S. 90:5047-5051.
5) Van Vactor, D., Sink, H., Fambrough, D., Tsoo, R., Goodman, C.S. (1993) Genes that Control Neuromuscular Specificity in Drosophila. Cell 73: 1137-1153.
6) Krueger, N.X., Van Vactor, D.L., Wan, H., Goodman, C.S., Gelbart, W., Saito, H. (1996) The Transmembrane Tyrosine Phosphatase DLAR Controls Motor Axon Guidance in Drosophila. Cell 84: 611-622.
7) Eberl, D.F., Ren, D., Feng, G., Lorenz, L.J., Van Vactor, D., and Hall, L.M. (1998) Genetic and Developmental Characterization of Dmca1D, a Calcium Channel a1 Subunit Gene in Drosophila melanogaster. Genetics, 148: 1159-1169.
8) Kaufmann, N., Wills, Z.P., and Van Vactor, D. (1998) Drosophila Rac1 Controls Motor Axon Guidance. Development, 125: 453-461.
9) Wills, Z., Marr, L., Zinn, K., Goodman, C.S. and Van Vactor, D. (1999) Profilin and the Abl Tyrosine Kinase are Required for Motor Axon Outgrowth in the Drosophila Embryo. Neuron 22, 291-299.
10) Wills, Z., Bateman, J., Korey, C., Comer, A., and Van Vactor, D. (1999) The Tyrosine Kinase Abl and its Substrate Enabled Collaborate with the Receptor Phosphatase Dlar to Control Motor Axon Guidance. Neuron 22, 301-312.
11) Bateman, J., Shu, H., Van Vactor, D. (2000) The Guanine Nucleotide Exchange Factor Trio Mediates Axonal Development in the Drosophila Embryo. Neuron 26, 93-106.
12) Bateman, J., Reddy, R.S., Saito, H. and Van Vactor, D. (2001) The receptor tyrosine phosphatase Dlar and
integrins organize actin filaments in the Drosophila follicular epithelium. Current Biology, 11:1317-1327.
13) Korey, C., Wilke, G., Davis, I. and Van Vactor, D. (2001) Multiple Developmental Roles for the Drosophila Homologue of the mRNA Transport Protein TAP/NXF1. Genetics 159, 1659-1670.
14) Wilkie, G.S., Zimani, V., Kirby, R., Korey, C., Francis-Lang, H., Van Vactor, D. and Davis, I. (2001) small bristles, DmNXF-1, is essential for mRNA export throughout Drosophila development. RNA 7, 1781-1792.
15) Kaufmann, N., DeProto, J., Ranjan, R., Wan, H. and Van Vactor, D. (2002) Drosophila Liprin-and the Receptor Phosphatase Dlar Cooperate During Synapse Morphogenesis. Neuron 34, 27-38.
16) Wills, Z., Emerson, M., Rusch, J., Bikoff, J., Baum, B., Perrimon, N., Van Vactor, D. (2002) A Drosophila Homologue of Cyclase-Associated-Proteins Collaborates with the Abl Tyrosine Kinase to Control Midline Axon Pathfinding. Neuron 36, 611-622.
17) Krueger, N.X., Reddy, S., Johnson, K.G., Bateman, J., , Kaufmann, N., Scalice, D.M., Van Vactor, D. and Saito, H. (2003) Structure-Function Analysis of Drosophila Protein Tyrosine Phosphatase Dlar In Vivo Using Mutated Dlar Transgenes. Mol. Cell. Biol. 23, 6909-6921.
18) Johnson, K.G., Ghose, A., Epstein, E., Lincecum, J., O’Connor, M.B. and Van Vactor, D. (2004) Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent Slit during midline axon guidance. Current Biology, 14, 499-504.
19) Lee, H., Engel, U., Rusch, J., Scherrer, S., Sheard, K. and Van Vactor, D. (2004) The microtubule plus-end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. Neuron, 42, 913-926.

INVITED REVIEWS
1) Nose, A., Van Vactor, D., Auld, V., Goodman, C.S. (1992) Development of Neuromuscular Specificity in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology, 57 : 441-449.
2) Zipursky, S.L., Krämer, H., Cagan, R., Hart, A., Van Vactor, D. (1992) Induction of the R7 Neuron in the Drosophila Compound Eye: The bride of sevenless and sevenless Interaction. Cold Spring Harbor Symposia on Quantitative Biology, Vol. 57 : 381-389.
3) Broadie, K., Sink, H., Van Vactor, D., Fambrough, D., Whitington, P.M., Bate, M., and Goodman, C.S. (1993) From Growth Cone to Synapse: The Life History of the RP3 Motor Neuron. Development Supplement 227-238.
4) Van Vactor, D. (1998) Adhesion and Signaling in Axonal Fasciculation . Current Opinion in Neurobiology 8: 80-86.
5) Van Vactor, D. (1998) Tyrosine Phosphatases in the Nervous System. Current Opinion in Cell Biology 10: 174-181.
6) Flanagan, J.G. and Van Vactor, D. (1998) Through the looking glass: Axon guidance at the midline choice point. Cell, 92: 429-432.
7) Van Vactor, D., O'Reilly, A.M. and Neel, B. (1998) Functional Analysis of Protein Tyrosine Phosphatases. Current Opinion in Genetics & Development, 8: 112-126.
8) Van Vactor, D. and Lorenz, L.J. (1999) The Semantics of Axon Guidance. Current Biology 9, R201-R204.
9) Van Vactor, D. and Flanagan, J.G. (1999) The Middle and the End: Slit Brings Guidance and Branching Together in Axon Pathway Selection. Neuron 22, 649-652.
10) Van Vactor, D. (1999) Axon Guidance. Current Biology 9, R797-R799.
11) Korey, C. and Van Vactor, D. (2000) From Growth Cone Surface to Cytoskeleton: one Journey, Many Paths. J. Neurobiol. 44: 184-193.
12) Rusch, J. and Van Vactor, D. (2000) New Roundabouts Send Axons into the Fas Lane. Neuron, 28, 637-640.
13) Bateman, J. and Van Vactor, D. (2001) The Trio Family of Guanine Nucleotide Exchange Factors: Key Regulators of Neuronal Morphogenesis. J. Cell Science. 114: 1973-1980.
14) Patel, B. and Van Vactor, D. (2002) Axon guidance: the cytoplasmic tail. Current Opinion in Cell Biology, 14, 221-229.
15) Ghose, A. and Van Vactor, D. (2002) GAPs in Slit-Robo signaling. Bioessays, 24, 401-404.
16) Johnson, K. and Van Vactor, D. (2002) Receptor Protein Tyrosine Phosphatases in Nervous System
Development. Physiological Reviews, 83:1-24.
17) Emerson, M. and Van Vactor, D. (2002) Roundabout is Abl to Regulate Cadherins. Nature Cell Biology, 4, E227-
E230.
18) Lee, H.. and Van Vactor, D. (2003) Neurons Take Shape. Current Biology 13, R152-R161.


BOOK CHAPTERS and EDITORIAL CONTRIBUTIONS
1) Van Vactor, D. and Kopczynski, C. (1999) Techniques for Anatomical Analysis of the Drosophila Embryonic Nervous System. in Richter, J. (ed.). A Comparative Methods Approach to the Study of Oocytes and Embryos. Oxford University Press, New York.
2) Van Vactor, D. (guest editor) (1999), Review Issue on "Axon Guidance". Cellular and Molecular Life Sciences 155, 1355-1407.
3) Engel, U. and Van Vactor, D. The roles of Ablelson family tyrosine kinases in axon guidance and synaptogenesis. In Koleske, A (ed.) Abl Family Kinases in Development and Disease. 2005, Landes Bioscience, Geargetown, TX.
4) Johnson, K.G. and Van Vactor, D. Heparan Sulfate Proteoglycans: Modulators of Axon Guidance and Synaptogenesis. In Bagnard, D. (ed.) Axon Growth and Guidance. 2005, Landes Bioscience, Geargetown, TX.



EXTRAMURAL FUNDING (Since 1996)

Fellowships & Scholarships:
“A Molecular Analysis of Axon Guidance in Drosophila” (Completed)
Principal Investigator: David L. Van Vactor, Ph.D. Period: 07/01/96 – 06/30/99
Agency (grant#): Klingenstein Fund; KLI96VAN404-03 Total Direct Costs = $120,000
Goals: The specific aim of this project is to identify novel components in the Dlar axon guidance pathway through dose-sensitive genetic screens for extragenic enhancer and/or suppressor loci.

“Analysis of Genes that Control Motor Axon Guidance in Drosophila” (Completed)
Principal Investigator: David L. Van Vactor, Ph.D. Period: 07/01/97 – 06/30/00
Agency (grant#): McKnight Foundation; MCK97VAN404-02 Total Direct Costs = $150,000
Goals: The specific aims of this project are analysis and molecular cloning of ziplock and circumventral, two novel genes required for motor axon guidance in Drosophila.

“Molecular Analysis of Fast Lane, A Novel Gene Required for Specific Axon Guidance” (Completed)
Principal Investigator: David L. Van Vactor, Ph.D. Period: 08/01/97 – 07/31/99
Agency (grant#): Medical Foundation; MED97VANV404-02 Total Direct Costs = $ 80,000
Goals: The specific aim of this project are genetic mapping, pheontypic analysis and molecular cloning of the fastlane gene, a component required for accurate motor axon pathfinding.

“Analysis of Novel Genes in the Abl Kinase Signaling Pathway” (Ongoing)
Principal Investigator: David L. Van Vactor, Ph.D. Period: 07/01/00 – 06/30/05
Agency (grant#): Leukemia and Lymphoma Society; LSA1600-01 Total Direct Costs = $475,000
Goals: the Aims are 1) molecular analysis of tetanic and its mechanism of action in axonogenesis, 2) the mechanism of Filamin function during axonogenesis, and 3) what proteins are encoded by the five novel Abl-interacting loci?

Grants:
“The Role of Receptor-Tyrosine Phosphatase Signaling in Motor Axon…” (Completed)
Principal Investigator: David L. Van Vactor, Ph.D. Period: 07/01/97 – 06/30/00
Agency (grant#): Council for Tobacco Research; 4713R1-02 Total Direct Costs = $220,118
Goals: The specific aims of this project are Aim 1 & 2) To test for functional redundancy between Dlar and DPTP69D or 99A in vivo and Aim 3 & 4) To identify PTPase substrates using a peptide library technique and fusion protein associations.

“Drosophila Genetics and Vertebrate Cell Biology” (Completed)
Principal Investigators: David Van Vactor, Ph.D. & Frank Gertler, Ph.D. Period: 07/01/99 – 06/30/00
Agency (grant#): Edgerly Science Partnership Fund Total Direct Costs = $ 34,091
Goals: The specific aims of this proposal are to (1) determine whether the mammalian Enabled homologue (Mena) is an associate or substrate for the mammalian LAR-family receptor protein tyrosine phosphatases, and (2) whether there is conservation in the functional domains of Ena and Mena as assessed in parallel vertebrate and invertebrate assay systems.

“Tyrosine Kinase Pathways that Control Axon Guidance” (Project 2) (Ongoing)
Principal Investigator: Chris A. Walsh, MD./Ph.D.
Project Leader: David L. Van Vactor, Ph.D. Period: 07/01/00 – 06/31/05
Agency (grant#): NIH/NINDS; 1 P01 Total Direct Costs = $872,732 (Est.)
Goals: the aims of the project are 1) analysis of the functional domains of Abl and Disabled, 2) the mechanism of Filamin function during axonogenesis, and 3) molecular analysis of tetanic and its mechanism of action during axonogenesis.

“Analysis of Genes Essential to Motor Axon Guidance in Drosophila” (Ongoing)
Principal Investigator: David L. Van Vactor, Ph.D. Period: 09/01/98 – 05/31/05
Agency (grant#): NIH/NINDS; 5 R01 NS35909-02 Total Direct Costs = $1,595,710
Goals: The current specific aims of this project are 1) The roles of Ena, Profilin and CAP in Dlar signaling mechanism 2) Genetic analysis of Dlar-associated proteins (d-Trio and d-Liprin-) 3) Molecular analysis of the magallan gene in motor axon guidance and 4) Molecular analysis of the circumventral gene in motor axon guidance.