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Binhai Zheng, Ph.D.
CONTACT INFORMATION
Mailing address: Department of Neurosciences,
EDUCATION AND EXPERIENCE
1988 – 1992 Fudan University,
1992 – 1994 School of Biological Sciences,
1994 – 1999 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas Ph.D. in Molecular and Human Genetics (1999) Thesis advisor: Dr. Allan Bradley
2000 – 2004 Department of Anatomy, and Howard Hughes Medical Institute, University of California at San Francisco; Department of Biological Sciences, and Howard Hughes Medical Institute, Stanford University, Stanford, California; Genentech, Inc., South San Francisco, California Postdoctoral associate with Dr. Marc Tessier-Lavigne
2005 - present Department of Neurosciences, University of California - San Diego, School of Medicine, La Jolla, California Assistant Professor (tenure-track)
AWARDS AND HONORS
1988-1991 University Scholarships, Fudan University 1994-1996 Cullen Foundation Predoctoral Fellowship, Baylor College of Medicine 1998 Outstanding Student Presentation Award, Department of Molecular and Human Genetics Annual Retreat, Baylor College of Medicine 1998 Selected as the department representative for platform presentation on the Annual Graduate Student Symposium, Baylor College of Medicine 2001-2004 Helen Hay Whitney Foundation Postdoctoral Fellowship 2005 The Ray Thomas Edwards Foundation Recognition Award
PUBLICATIONS
1. Roy, J., Zheng, B., Rymond, B. C., and Woolford, J. L., Jr. (1995). Structurally related but functionally distinct yeast Sm D core small nuclear ribonucleoprotein particle proteins. Mol. Cell. Biol. 15, 445-55.
2. Justice, M. J., Zheng, B., Woychik, R. P., and Bradley, A. (1997). Using targeted large deletions and high-efficiency N-ethyl-N- nitrosourea mutagenesis for functional analyses of the mammalian genome. Methods 13, 423-36.
3. Prolla, T. A., Baker, S. M., Harris, A. C., Tsao, J. L., Yao, X., Bronner, C. E., Zheng, B., Gordon, M., Reneker, J., Arnheim, N., Shibata, D., Bradley, A., and Liskay, R. M. (1998). Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat. Genet. 18, 276-9.
4. Bradley, A., Zheng, B., and Liu, P. (1998). Thirteen years of manipulating the mouse genome: a personal history. Int. J. Dev. Biol. 42, 943-50.
5. Seipelt, R. L., Zheng, B., Asuru, A., and Rymond, B. C. (1999). U1 snRNA is cleaved by RNase III and processed through an Sm site-dependent pathway. Nucleic Acids Res. 27, 587-95.
6. Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R., and Bradley, A. (1999). p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398, 708-13.
7. Zheng, B., Mills, A. A., and Bradley, A. (1999). A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Res. 27, 2354-60.
8. Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., and Bradley, A. (1999). The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400, 169-73.
9. Zheng, B., Sage, M., Cai, W. W., Thompson, D. M., Tavsanli, B. C., Cheah, Y. C., and Bradley, A. (1999). Engineering a mouse balancer chromosome. Nat. Genet. 22, 375-8.
10. Justice, M. J., Noveroske, J. K., Weber, J. S., Zheng, B., and Bradley, A. (1999). Mouse ENU mutagenesis. Hum. Mol. Genet. 8, 1955-63.
11. Zheng, B., Sage, M., Sheppeard, E. A., Jurecic, V., and Bradley, A. (2000). Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications. Mol. Cell. Biol. 20, 648-55.
12. Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der Horst, G. T., Hastings, M. H., and Reppert, S. M. (2000). Interacting molecular loops in the mammalian circadian clock. Science 288, 1013-9.
13. Albrecht, U., Zheng, B., Larkin, D., Sun, Z. S., and Lee, C. C. (2001). mPer1 and mPer2 are essential for normal resetting of the circadian clock. J. Biol. Rhythms 16, 100-4.
14. Zheng, B., Mills, A. A., and Bradley, A. (2001). Introducing defined chromosomal rearrangements into the mouse genome. Methods 24, 81-94.
15. Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., and Lee, C. C. (2001). Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105, 683-94.
16. Cleary, M. A., van Raamsdonk, C. D., Levorse, J., Zheng, B., Bradley, A., and Tilghman, S. M. (2001). Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice. Nat. Genet. 29, 78-82.
17. Kopp, C., Albrecht, U., Zheng, B., and Tobler, I. (2002). Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice. Eur. J. Neurosci. 16, 1099-106.
18. Zheng, B., Vogel, H., Donehower, L. A., and Bradley, A. (2002). Visual genotyping of a coat color tagged p53 mutant mouse line. Cancer Biol. Ther. 1, 433-5.
19. Steward, O., Zheng, B., and Tessier-Lavigne, M. (2003). False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J. Comp. Neurol. 459, 1-8.
20. Zheng, B., Ho, C., Li, S., Keirstead, H., Steward, O., and Tessier-Lavigne, M. (2003). Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 38, 213-24.
21. Steward, O., Zheng, B., Ho, C., Anderson, K., and Tessier-Lavigne, M. (2004). The dorsolateral corticospinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions. J. Comp. Neurol. 472, 463-77.
22. Karnezis, T., Mandemakers, W., McQualter, J. L., Zheng, B., Ho., P. P., Jordan, K. A., Murray, B. M., Barres, B., Tessier-Lavigne, M., Bernard, C. C. (2004). The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat. Neurosci. 7, 736-44.
23. Fontoura, P., Ho, P. P., DeVoss, J., Zheng, B., Lee, B. J., Kidd, B. A., Garren, H., Sobel, R. A., Robinson, W. H., Tessier-Lavigne, M., Steinman, L. (2004). Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J. Immunol. 173, 6981-92.
24. Zheng, B.*, Atwal, J.*, Ho, C., Case, L., He, X. L., Garcia, K. C., Steward, O., and Tessier-Lavigne, M. (2005). Genetic deletion of Nogo Receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc. Natl. Acad. Sci. USA. 102, 1205-10. * Equal contributors.
25. Anderson, D. K, Beattie, M., Blesch, A., Bresnahan, J., Bunge, M., Dietrich, D., Dietz, V., Dobkin, B., Fawcett, J., Fehlings, M., Fischer, I., Grossman, R., Guest, J., Hagg, T., Hall, E. D., Houle, J., Kleitman, N., McDonald, J., Murray, M., Privat, A., Reier, P., Steeves, J., Steward, O., Tetzlaff, W., Tuszynski, M. H., Waxman, S. G., Whittemore, S., Wolpaw, J., Young, W., Zheng, B. (2005). Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord 43, 453-8.
PRESENTATIONS AND LECTURES
Zheng, B., Rymond, B. C., Roy, J., and Woolford, J. L. (1994). Yeast core snRNP structure. The RNA processing meeting of the RNA Society, Madison, Wisconsin.
Zheng, B. (1998). An efficient system for chromosome engineering in mice. The 10th Annual Graduate Student Symposium, Baylor College of Medicine, Houston, Texas.
Zheng, B., Mills, A. A., Jurecic, V., and Bradley, A. (1998). An efficient system for chromosome engineering in mice. Meeting on Conditional Genetic Technologies in the Mouse, Cold Spring Harbor, New York.
Zheng, B., Sun, Z. S., Larkin, D. W., Patrick, J. W., Lee, C. C., Bradley, A. (1998). Functional analysis of mouse mPer1 and mPer2 in circadian rhythms by gene targeting. Meeting on Mouse Molecular Genetics, Cold Spring Harbor, New York.
Zheng, B. (2000). Large scale genome manipulation. The Croucher Foundation Advanced Study Institute, the University of Hong Kong, Hong Kong.
Zheng, B. (2000). Manipulating the mouse genome: single gene knockouts and large chromosomal rearrangements. Department of Genetics and Genetic Engineering, Fudan University, Shanghai, China.
Zheng, B., Steward, O., and Tessier-Lavigne, M. (2002). Genetic analysis of Nogo in adult spinal regeneration. International Spinal Research Trust Annual Meeting, London, United Kingdom.
Zheng, B., Gonzales, R., Keirstead, H., Steward, O., and Tessier-Lavigne, M. (2002). Genetic analysis of Nogo function in adult spinal regeneration. Meeting on Axon Guidance and Neural Plasticity, Cold Spring Harbor, New York.
Zheng, B., Ho, C., Keirstead, H., Steward, O., and Tessier-Lavigne, M. (2003). Genetic analysis of Nogo and Nogo-66 Receptor function in adult spinal regeneration. EMBO Workshop on the Assembly of Neural Circuits, Varenna, Italy.
Zheng, B. (2005). The role of Nogo in CST regeneration failure: what are the mouse models telling us? California Spinal Cord Injury / Neural Regeneration Consortium, Roman Reed Research Meeting, Irvine, California.
Zheng, B. (2005). The role of inhibitory molecules in CNS axon regeneration failure: insights from mouse models. International Spinal Research Trust Annual Meeting, London, United Kingdom.
Zheng, B. (2005). Axon regeneration in the mammalian CNS: insights from mouse models. Merck neurosciences seminar, University of California, San Diego.
Zheng, B. (2006). Myelin inhibitors in CNS axon regeneration - functional redundancy and an initial application of a genetic tracer. California Spinal Cord Injury / Neural Regeneration Consortium, Roman Reed Research Meeting, Irvine, California.
PATENTS
Bradley, A., Ramirez-Solis, R., Liu, P., Su, H., and Zheng, B. Method for chromosomal rearrangement by consecutive gene targeting of two recombination substrates to the deletion endpoints. United States Patent No. 6,077,667. (June 20, 2000).
