David X. Liu, Ph.D.
Department of Neural and Behavioral Sciences
Pennsylvania State University College of Medicine
EMAIL: dliu@psu.edu
EDUCATION
1997 Ph.D., Molecular Genetics. City University of New York, New York, NY.
1986 M.S. Molecular Biology. Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1982 B.S. Biochemistry. Fudan University, Shanghai, China
POSITIONS HELD
2007-present Member, Cell and Molecular Biology Advisory Committee, Penn State Univ. College of Medicine.
2006-present Assistant Professor, Dept. of Neural and Behavioral Sci., Penn State Univ. College of Medicine.
Member, Penn State Cancer Institute, Penn State Univ. College of Medicine.
Member, Penn State Neuroscience Institute, Penn State Univ. College of Medicine.
2006-present Graduate Faculty of Anatomy Program, Cell and Developmental Biology Program, Cell and Molecular Biology Program, Genetics Program, M.D/Ph.D Program, and Neuroscience Program, Penn State Univ.
2002-2006 Associate Research Scientist. Advisor: Lloyd A. Greene, Ph.D.
Columbia University College of Physicians and Surgeons, New York, NY.
1998-2002 Postdoctoral fellow. Advisor: Lloyd A. Greene, Ph.D.
Columbia University College of Physicians and Surgeons, New York, NY.
1996-1998 Postdoctoral fellow. Advisor: Michele Pagano, M.D.
New York University Medical Center, New York, NY.
1991-1996 Graduate Research Assistant. Advisor: Rivka Rudner, Ph.D.
Dept. of Biological Sciences, City University of New York, New York NY.
1989-1991 Visiting Research Specialist. Dept. of Biological Sciences, Univ. of Illinois at Chicago, IL.
1988-1992 Assistant Professor. Dept. of Biochemistry, Qingdao University, Qingdao, China.
1986-1987 Research fellow. Shanghai institute of Biochemistry, Shanghai, China.
TEACHING EXPERIENCE
Genetics 597, 2007. Director: Dr. Sarah Bronson, PSU College of Medicine
Genetics 590, 2007. Director: Dr. Laura Carell, PSU College of Medicine
Structural Basis of Medical Practice, 2006. Director: Dr. Ian S. Zagon, PSU College of Medicine
Biochemistry, Coordinator: Prof. Guren Jiang & Assist. Prof. David Liu, Qingdao University
Cell and Molecular Biology, Coordinator: Assist. Prof. David Liu, Qingdao University
Principle Biology, Coordinator: Prof. Roger Percell, City Univ. of NY
Cell Biology, Coordinator: Prof. Roger Percell, City Univ. of NY
Microbiology, Coordinator: Prof. Marvin Friedman, City Univ. of NY
Molecular Genetics, Coordinator: Prof. Rivka Rudner, City Univ. of NY
GRANTS, AWARDS AND HONORS RECEIVED
Lab Start Fund (Penn State University College of Medicine)
Blanchette Rockefeller Foundation (Columbia University).
NIH Neurobiology Institutional Grand (Columbia University).
NIH postdoctoral training fellowship (New York University).
University of Illinois at Chicago Visiting Research Specialist Award.
Outstanding Research Award (Shanghai Institute of Biochemistry, China)
MEMBERSHIP AND OTHER ROFESSIONAL ACTIVITIES
American Association for Cancer Research
Society for Neuroscience
Ad Hoc article reviews for the following Journals: J. Biological Chemistry; Biochimica et Biophysica Acta; J. Qingdao; and Brain Res. Bulletin
INVITED TALKS
Department of Neurology, Columbia University, New York, NY. 2007
Department of Neurosurgery, PSU College of Medicine, Hershey, PA. 2007
Massachusetts Eye and Ear Infirmary, Harvard University, Boston, MA. 2006
University of Virginia School of Medicine, Charlottesville, VA. 2006
Motor Neuron Center, Columbia University, New York, NY. 2006
Maimonides Medical Center, Mount Sinai Medical School, New York, NY. 2005
Penn State University Hershey Medical School, Hershey, PA. 2005
Northwestern University, Chicago, IL. 2005
University of California, Davis, CA. 2005
City University of New York, New York, NY. 2004
Shanghai Institute of Biochemistry, Chinese Academy of Sci, Shanghai, China. 2002
Institute of Genetics, Fudan University, Shanghai, China. 2002
Institute of Cancer Genetics, Columbia University, New York, NY. 2001
PUBLICATIONS
Ding Y and *Liu DX (2007) Cycling to Death: Involvement of Cell Cycle Molecules in Neuronal Apoptosis. In: Cell Apoptosis Research Advances. Ed. Carter. R. Kattleworth. Nova Scientific, New York, NY. pp 23-41.
Greene LA, Liu DX, Troy CM, and Biswas SC (2007) Cell Cycle Molecules Define A Pathway Required For Neuron
Death In Development And Disease. Biochimica et Biophysica Acta 1772(4):392-401.
Biswas SC, Liu DX, and Greene LA (2005) Bim is a direct target of a neuronal E2F-dependent apoptotic Pathway.
J. Neurosci., 25(37):8349-58.
*Liu DX, Nath N, Chellappan SP, and Greene LA (2005). Regulation of neuronal survival and death by p130 and
associated chromatin modifiers. Genes&Dev. 19(6):719-32.
*Liu DX, Biswas SC, and Greene LA (2004). B-myb and C-myb play required roles in neuronal apoptosis evoked by
NGF deprivation and DNA damage. J. Neurosci. 24(40):8720-5.
Greene LA, Biswas SC, and Liu DX (2004). Cell cycle molecules and vertebrate neuron death: E2F at the hub.
Cell Death Differ. 11(1):49-60.
*Liu DX and Greene LA (2002). Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res.
305(2):217-28.
*Liu DX and Greene LA (2001). Regulation of neuronal survival and death by E2F-dependent gene repression and
derepression. Neuron 32(3):425-38.
Angelastro JM, Moon NY, Liu DX, Yang AS, Greene LA, Franke TF (2001). Characterization of a novel isoform of
caspase-9 that inhibits apoptosis. J. Biol. Chem. 276(15):12190-200.
Zhang Y, Wang Z, Liu DX, Pagano M, Ravid K (1998). Ubiquitin-dependent degradation of cyclin B is accelerated in
polyploid megakaryocytes. J. Biol. Chem. 273(3):1387-92.
Lu Z, Liu DX, Hornia A, Devonish W, Pagano M, Foster DA (1998). Activation of protein kinase C triggers its
ubiquitination and degradation. Mol. Cell. Biol. 18(2):839-45.
*Liu DX (1990). DNA regions in the genome of silkworm Attacas ricini contains sequences that structurally and
functionally resembles both eukarotic and prokaryotic promoters. J. Qingdao Univ. 2(1):88-94.
*Liu DX and He X (1989). Study on plasmids harbored in thermophilic bacteria – Isolation and characterization of
plasmids from Bacillus thermophilus. Chinese J. Biochemistry 5(1):56-60.
*Liu DX, Shen L and Li Z (1989). Attacus ricini genomic DNA contains regions that can act as prokaryotic promoters.
J. Genetics (English). Allerton Press, New York, NY. 15(1):59-72.
Liu DX, Shen L and Li Z (1988). Cloning and characterization of DNA fragments from the genome of silkworm
A. ricini that function as promoters in E. coli. Acta Genetica Sinica 15(2):102-10.
__________________________________________________
* corresponding author
SELECTIVE ABSTRACTS AND PRESENTATIONS
Liu DX, Lee, H and Greene LA. Interference of ATF5 function induces apoptosis in DAOY medulloblastoma cells.
The 36th Annual Neurosci. Meeting. Atlanta, GA, 2006.
Liu DX, Biswas SC and Greene LA. B-myb and C-myb play required roles in neuronal apoptosis evoked by NGF
deprivation and DNA damage. The 35th Annual Neurosci. Meeting. Washington, DC, 2005.
Liu DX, Nath N, Chellappan SP, and Greene LA. Disassembly of the repressor complex E2F-p130- HDAC- Suv39H1
is required for neuronal apoptosis. The 10th SCBA Intl. Symp., Beijing, China, 2004.
Liu DX, Nath N, Chellappan SP, and Greene LA. Regulation of neuronal survival and apoptosis by the E2F-p130-
HDAC-Suv39H1 complex. Cold Spring Harbor Symposium: Programmed Cell Death.
Cold Spring Harbor, New York, NY, 2003.
Liu DX, Biswas SC and Greene LA. Regulation of neuronal survival and death by E2F and derepression.
The 32nd Annual Neuroscience Meeting. San Diego, California, 2002.
Liu DX and Greene LA. Inhibition of the cell cycle G1 phase is sufficient to promote neuronal survival.
Gordon Res. Conference: Mol. Neural Biology. Hong Kong, China, 2001.
Carrano A, Chiaur J, DeSalle L, Liu DX, Montagnoli A and Pagano M. Cell cycle inhibitor p27 as a prognostic marker
for colon cancers. Cold Spring Harbor Symposium: Cell Cycle Regulation.
Cold Spring Harbor, New York, NY, 1998.
Lu Z, Liu DX, Hornia A, Devonish W, Pagano M and Foster DA. Activation of protein kinase C triggers its
ubiquitination and degradation. The 13th Ann. Oncogene Meeting. Friedgrick, MD, 1997.
Liu DX, Samarrai W, White A and Rudner R. Heterogeneity in expression of rRNA operons and the stringent response
in B. subtilis. Gordon Research Conference: Ann. Conference on B. subtilis. Wind River, CO, 1995.
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