Name: Lan Bao (鲍  岚)

Sex: Female

Birth day: December 18, 1964

Place of birth: Shaoxing, Zhejiang, P.R.China

 

Academic experience:

August, 1980  Medical student, 4^th Military Medical University (FMMU), Xi’an, P.R

             China

August, 1985  MD, FMMU, Xi’an, P.R. China

August, 1985  post-graduate student, Department of Aerospace Physiology, FMMU,

             Xi’an, P.R. China

August, 1988  Master Degree of Medicine, FMMU, Xi’an, P.R. China

September, 1988  Teaching assistant, Department of Aerospace Physiology, FMMU,

             Xi’an, P.R. China

September, 1990  Lecture, Department of Aerospace Physiology, FMMU, Xi’an,

             P.R. China

August, 1993  Guest scientist, Department of Neuroscience, Karolinska Institute,

             Stockholm, Sweden

August, 1994  Lecture, Department of Aerospace Physiology, FMMU, Xi’an,

             P.R. China

September, 1996  Associate professor, Department of Aerospace Physiology, FMMU,

             Xi’an, P.R. China

June, 1999  PhD, Department of Aerospace Physiology, FMMU, Xi’an, P.R. China

November, 1999 Associate professor, Laboratory of Sensory System, Institute of

             Neuroscience, Chinese Academy of Sciences, P.R. China

 

Award:

1990 Fourth award for progress in science and technology of PLA (China)

1992 Third award for progress in science and technology of PLA (China)

1993 Third award for progress in science and technology of PLA (China)

1996 Second award for progress in science and technology of PLA (China)

1996 Frist award for progress in science and technology of PLA (China)

1997 Third award for progress in science and technology of China (China)

研究工作

在生理和病理条件下神经肽受体（G蛋白偶连受体超家族成员）和离子通道在初级感觉神经元兴奋性的调控中起重要作用，因此了解调控细胞表面神经肽受体和离子通道转运的分子和细胞机制至关重要。
我们将应用分子克隆、抗体制备、免疫荧光双标记、共聚焦显微镜和免疫电子显微镜等技术系统地分析不同神经肽受体亚型和离子通道在细胞和亚细胞水平的分布特征；用免疫共沉淀、细胞表面生物素化、Western Blot和基因突变等技术, 寻找对其包装和运输途径产生决定性作用的分子和受体、离子通道本身的氨基酸序列；用电生理膜片钳和膜电容记录技术对其功能进行分析。
通过研究明确不同神经肽受体亚型和离子通道的细胞与亚细胞水平分布特征；建立G蛋白偶连受体和离子通道包装运输途径和调控的分子和细胞生物学模型；确认一些在病理条件下调控神经肽受体（G蛋白受体）和离子通道分泌和运输的分子和细胞生物学模型。
以上研究一方面对细胞和神经生物学基本理论有重要意义；另一方面发现一些与痛的发生和发展有关的重要机制和重要分子，对寻找新的镇痛方案和新药开发将提供有价值的新线索。 

 

Publication

1.    鲍  岚, 吴兴裕, 韩学平, 王兴邦, 张  荣, 张立藩.  中度体力负荷人体肺通气量、心率反应数学模型的辨识. 航天医学与医学工程 1989; 2(2): 20～25

2.    吴兴裕, 韩学平, 王兴邦, 鲍  岚, 李志学, 张立藩.  化学负荷下口腔关闭压(P0.1)与肺通气功能的相关关系. 中国用生理学杂志 1989; 5(4): 371～376

3.    吴兴裕, 韩学平, 王兴邦, 鲍  岚, 张立藩.  缺氧或二氧化碳负荷下通气功能及呼吸型式的比较. 第四军医大学学报  1989; 10(2): 82～86

4.    吴兴裕, 鲍  岚, 张立藩. 用口腔关闭压评估低氧敏感性的研究.中华航空医学杂志  1990; 1(1): 17～20

5.    鲍  岚, 王兴邦, 冯林华, 张立藩.  不同强度体力负荷下的平均呼吸流率曲线. 第四军医大学学报  1990; 11(4): 288～291

6.    鲍  岚, 张立藩, 吴兴裕, 李志学.  运动时逐次呼吸口腔关闭压测量对肺通气量及呼吸型式的影响. 第四军医大学学报  1991; 12(4): 278-281

7.    鲍  岚, 吴兴裕, 肖赞英, 张立藩.  不同条件下呼吸型式变化及流率曲线测量. 中华航空医学杂志 1991; 2(1):9-12

8.    Wu X.Y., Bao L., Zhang L.F.   Measurement  of individual hypoxic sensitivity by means of  mouth  occlusion pressure. J Med Coll PLA 1991; 6(1): 26-31

9.    鲍  岚, 李云修, 赵  民. 一次飞行中发生的五例高空减压病. 中华航空医学杂志 1992; 3(4): 222-224

10.程九华, 鲍  岚, 程宏伟, 张立藩, 董秀珍. SF-90 心肺阻抗同步检测仪在呼吸阻力图测量中的应用. 第四军医大学学报 1993; 14(2): 96-100

11.鲍  岚, 张立藩. 飞行中人体的呼吸生理反应. 中华航空医学杂志 1994; 5(2):123-128

12.Zhang X., Dagerlind A., Bao L., Ji R.R., Lundberg J.M. and Hökfelt T. Increased expression of galanin in the  rat superior cervical ganglion after  pre-   and  postganglionic nerve lesions. Experimental Neurology 1994; 127: 9-22

13.Zhang X., Bao L., Xu Z.Q., Kopp J., Arvidsson U., Elde R., and Hökfelt T.  Localization  of  neuropeptide  Y  Y1 receptors in the rat nervous system with  special  reference to somatic receptors on small dorsal root ganglion neurons.  Proc. Natl. Acad. Sci. USA 1994; 91: 11738-11742

14.Zhang X., Xu Z.Q., Bao L., Dagerlind A. and Hökfelt T. Complementary distribution of  receptors  for  neurotensin  and NPY and their relation to neuropeptides: Evidence for  a unique subpopulation of small DRG neurons. J Neuroscience 1995; 15: 2733-2747

15.程宏伟, 马瑞山, 鲍  岚. 心阻抗图的整体平均处理. 第四军医大学学报1994; 15(5): 369-372

16.Zhang X., Bao L., Xu Z.Q., Diez M., Frey P. and Hökfelt T. Peripheral axotomy induces increased expression of neurotensin in large neurons in rat lumbar dorsal root ganglia. Neuroscience Research 1996; 25: 359-369

17.Bao L., Kopp J., Zhang X., Xu Z.Q.D., Zhang L.F., Wong H., Walsh J and Hökfelt T. Loc alization of neuropeptide Y Y1 receptors in cerebral blood vessels. Proc Natl Acad Sci USA 1997; 94: 12661-12666

18.Hökfelt T., Broberger C., Zhang X., Diez M., Kopp J., Xu Z.-Q., Landry M., Bao L., Schalling M., Koistinaho J., DeArmond S.J., Prusiner S., Gong J., Walsh J.H. (1998) Neuropeptide Y: some viewpoints on a multifaceted peptide in the normal and diseased nervous system. Brain Res. Rev., 26: 154-166.

19.Zhang X., Bao L., Shi T.J., Ju G., Elde R. and Hökfelt T. Down-regulation of μ-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy. Neuroscience 1998; 82: 223-240

20.Zhang X., Bao L., Arvidsson U., Elde R. and Hökfelt T. Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: evidence for association with the membrane of large dense-core vesicles. Neuroscience 1998; 82: 1225-1242

21.Zhang X., Tong Y.G., Bao L. and Hökfelt T. The neuropeptide Y Y1 receptor is a somatic receptor on dorsal root ganglion neurons andd a postssynaptic receptor on somatostatin dorsal horn neurons. Europ J Neurosci 1999; 11(7): 2211-2225

22.鲍 岚，林英华，张 旭. 神经肽Y Y1受体样免疫反应物质在大鼠冠状血管中的分布。第四军医大学学报 2000； 21（1）：1-6

23.Xiao H-S., Huang Q-H., Zhang F-X., Bao L., Lu Y-J., Guo C., Yang L., Huang W-J., Fu G., Xu S-H., Cheng X-P., Yan Q., Zhu Z-D., Zhang X., Chen Z., Han Z-G. and Zhang X. (2002) Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc. Natl. Acad. Sci., in press

24.Bao L., Wang H. F., Cai H-J., Tong Y-G., Jin S-X., Lu Y-J., Grant G., Hökfelt T., Zhang X. (2002) Peripheral axotomy induces only very limited sprouting of coarse myelinated afferents into inner lamina II of rat spinal cord. Eur. J. Neurosci., 16: 175-185

25. L. Bao, S-X. Jin, C. Zhang, L-H. Wang, Z-Z. Xu, F-X. Zhang, L-C. Wang, F-S. Ning, H-J. Cai, J-S. Guan, H-S. Xiao, Z-Q. D. Xu, C. He, T. H?kfelt, Z. Zhou and X. Zhang (2002) Activation of delta-opioid receptors induces receptor insertion and neuropeptide secretion. Neuron, in press 

Reviews

Hökfelt T., Broberger C., Zhang X., Diez M., Kopp J., Xu Z.Q., Landry M., Bao L., Schalling M., Koistinaho J., DeArmond S.J., Prusiner S., Gong J., Walsh J.H. Neuropeptide Y: some viewpoints on a multifaceted peptide in the normal and diseased nervous system. Brain Res Rev 1998; 26: 154-166

 

Chapters

Zhang X., Xu Z.Q., Shi T.J., Landry M., Holmberg K., Ju G., Tong Y.G., Bao L., Cheng X.P., Wiessenfeld-Hallin Z., Lozano A., Dostrovsky J. and Hökfelt T. Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation. In: Galanin, Basic research discoveries and therapeutic implications, Ann NY Acad Sci, 863, 403-413

生物化学与细胞生物学研究所鲍岚组招聘启事

 

中国科学院生物化学与细胞生物学研究所鲍岚组主要从事感觉神经元中蛋白质运输的分子和细胞机制及与疼痛发生发展的相关性研究，目前需要招聘一名助理研究员/实验师，从事相关的科学研究工作。

 

基本要求：

 

1． 医学或生物学专业硕士或博士学位获得者；

 

2． 有分子生物学/细胞生物学/神经生物学研究经历；

 

3． 工作认真负责，有较强的敬业精神和团队合作精神。

 

有意应聘者请提供：本人简历至（符合要求者，将安排面试，面试时需提交学历及相关证明、资格证书和身份证复印件。）