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| Prof. Harmen Krugers |
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| 更新：2008-3-19 来源：本站原创 【字体：小 大】 |
General Information
Name Harmen Krugers
Date of birth 31 March 1966
Place of birth Goirle
Nationality Dutch
Present address (work) Swammerdam Institute for Life Sciences
University of Amsterdam
Kruislaan 320
1098 GB Amsterdam
The Netherlands
Phone 020 525 7621
Fax 020 525 7709
Email krugers@bio.uva.nl
(home) Chico Mendesstraat 27
3573 AW, Utrecht
Phone 030 2 71 71 93
Employment Record
- October ’99-present Assistant Professor Swammerdam Institute for Life Sciences,
Institute of Neurobiology, University of Amsterdam, The Netherlands
- October ’98-October ‘99 Post-doctoral fellow at the Dept Neurosciences, University of
California, San Diego, USA
- April ’96-October ‘98 Post-doctoral fellow at the Dept Experimental Zoology, Institute
of Neurobiology, University of Amsterdam, The Netherlands
- Sept ‘91-April ’96 Ph.D. student at the Dept Biological Psychiatry, University of
Groningen, The Netherlands
· Sept ‘90-Sept ’91 Ph.D. student at the Rudolf Magnus Institute for Pharmacology,
University of Utrecht, The Netherlands
Educational record
- April ’96 Doctorate’s degree (cum laude) at the Dept of Biological
Psychiatry, University of Groningen (Prof Dr J Korf). Title thesis: The rat brain as target for stress and corticosterone: morphological, immunocytochemical and behavioral studies on the rat hippocampus.
- August ’90 Doctoral examination Medical Biology (University of Groningen,
The Netherlands)
- January ’86 Candidate’s examination Biology (Catholic University of
Nijmegen, The Netherlands)
- Sept ‘79-Sept ’84 Highschool at the “RSG Koning Willem II” in Tilburg, The
Netherlands
Seminars
- January 9, 1995 Institute of Neurobiology, University of Amsterdam
- February 21, 1995 Dept Biological Psychiatry, University of Groningen
- April 10, 1995 Sylvius Laboratories, University of Leiden
- December 6, 1995 McGill University, Montreal (Canada)
- June 14, 1996 Heinrich-Heine University, Düsseldorf (Germany)
- May 14, 1997 Max Planck Institute for Experimental Medicine, Göttingen
(Germany)
- June 5, 1998 Second Endo-Neuro meeting, Doorwerth
- January 19, 1998 Dept Biological Psychiatry, University of Groningen
- January 22, 2001 Dept Biological Psychiatry, University of Groningen
- June 7, 2001 Endo-Neuro meeting, Doorwerth
- July 2, 2004 CSCA Summer school, Amsterdam
- July 5, 2004 CSCA Summer school, Amsterdam
- September 2004 Workshop on Neurogenesis, Amsterdam
- November 2004 University of Mainz, Germany
- March 7, 2005 University of Amsterdam, SILS-CNS
- April 14, 2005 German Primate Center Göttingen, Germany; emotional
memories, modulation by corticosteroid hormones
- August 31, 2005 Qingdao Medical Faculty, Qingdao University, China;
Corticosteroid modulation of hippocampal synaptic efficacy
- September 20, 2005 Rudolf Magnus Institute for Pharmacology, Utrecht,
Corticosteroid modulation of hippocampal synaptic efficacy
- October 23, 2005 Workshop 'animal models in cognitive neuroscience', Oud
Poelgeest; Bi-directional modulation of synaptic efficacy by corticosteroid hormones
- December 20, 2005 Dept Animal Physiology, Haren, the Netherlands. Corticosteroid modulation of hippocampal synaptic plasticity.
- January 24, 2006 Academic Medical Center, University of Amsterdam, The Netherlands Corticosteroid modulation of hippocampal synaptic efficacy: receptors on the move?
- February 27, 2006 BCN lecture Dept Biological Psychiatry, RU Groningen. The yin
and yang of corticosteroid hormones: modulation of learning and memory and synaptic efficacy.
- April 10, 2006 University Nijmegen, Dept. Corticosteroid hormones and synaptic efficacy: good guys or bad guys?
- May 23, 2006 NEMO, Bessensap 2006: Traumatische herinneringen in een
reageerbuis.
· September 29, 2006 Corticosteroid modulation of AMPA receptor localization (RijksUniversiteit Groningen)
· January 5, 2007 Hormonal modulation of AMPA receptor function, Universiteit van Amsterdam, The Netherlands
· February 23, 2007 Cortisol en Depressie, afscheidssymposium Jaap Korf, UMCG, Groningen
· May 24, 2007 Hormonal control of molecular mechanisms involved in
learning and memory, IBANGS symposium , Doorwerth, The Netherlands
· June 8, 2007 Hormonal control of molecular mechanisms involved in
learning and memory, 6th Dutch Endo-Neuro Meeting, Doorwerth, The Netherlands
· October 5, 2007 Hormonal control of molecular mechanisms involved in
Emotional memories, EPFL, Lausanne, Switserland
· November 20, 2007 University Maastricht, The Netherlands
· November 28 Max Planck Institute for Psychiatry, Munich
Management
- ALW beoordelingscommissie 2007 and 2008
- Member steering committee ENP 2008
- Organizer and chairman symposium Stress, corticosteroid hormones and depression, FENS 2006, Vienna.
- Organizer and chairman symposium Molecular and cellular mechanisms underlying fearful memories; EndoNeuromeeting, Doorwerth, 2006.
- Organizer and chairman symposium Stress, emotions and memory modulation; EndoNeuromeeting, Doorwerth, 2006.
- Organizer Masterclass Synaptic structure, function, and plasticity (March 2nd 2006); University of Amsterdam.
- Co-Promotor Deborah Alfarez (March 2006)
- Organizer and chairman symposium Hormones, plasticity and behaviour; EndoNeuromeeting, Doorwerth, 2005.
- Graduation committee Vivi Heine, 2004
- Organizer and chairman symposium “Early life events, life long consequences, EndoNeuromeeting, Doorwerth, 2003.
- Organizer and chairman symposium “The Stressed Brain” at FENS meeting 2002
- Graduation committee Annette van Kalkeren, 2002
Committees/Boards
· Editorial Board Frontiers in Neuroscience
- Member NWO Committee “Molecuul tot Organisme”
- Member Steering Committee Dutch ENP meeting
- Member Animal Experimental committee University of Amsterdam (2000 - )
- Coordinator regulations experimental animals Swammerdam Institute for Life Sciences
Collaborations
- Dr Melly Oitzl, Leiden University Medical Center, Dept medical Pharmacology, Leiden, The Netherlands
- Dr Casper Hoogenraad, Erasmus University Rotterdam
- Dr G Ramakers, Netherlands Institute for Brain Research
- Dr F van Leeuwen, Netherlands Institute for Brain Research
- Dr J Henley, University of Bristol
- Dr Frances Edwards, University College London, UK
- Dr Tang Ming, Qingdao Medical Faculty, Qingdao, China
· Dr Mark Mayford, University of California San Diego, U.S.A
· Dr Maryann Martone, University of California San Diego, U.S.A
Grants
· November 2007 Royal Dutch Academy of Sciences, China exchange program (with Marian Joëls)
· December 2005 Hersenstichting Nederland-grant 13F05.02
· April 2005 Royal Dutch Academy of Sciences, China exchange program
(05CDP013)
· April 2002 NWO-grant 051.02.010
· February 2002 Hersenstichting Nederland-grant 10F02.38
· February 2000 NWO-grant 903-47-076
· April ’98 “TALENT”-Stipendium NWO
· March ’95 Dr Saal van Swanenbergstichting (grant kw/obr/95-04)
Teaching activities
- Coordination 7- weeks course “Endocrinology”, (Medical) Biology, UvA
- Coordination minicursus “proefdiergebruik”, UvA
- Teaching in 4-weeks course “Neurobiology”, (Medical) Biology, UvA
- Teaching in 4- weeks course “Neurobiological Techniques”, (Medical Biology) UvA
- Teaching in 3-weeks course “Miniscriptie”, (Medical) Biology, UvA
- Coordination + Teaching in AIO course Advanced Neurobiology
- Teaching in Capita Selecta Neurobiology and Endocrinology, Leiden University
- Teaching Cardiovascular systems in 7-weeks course “Animal and Human Physiology”, UvA
Publications:
1. Wiegert O, Joëls M, Krugers HJ. (2008) Corticosteroid hormones, synaptic strength and emotional memories: corticosteroid modulation of memory -- a cellular and molecular perspective. Prog Brain Res. 167: 269-71.
2. Joëls M, Krugers H, Karst H. (2008) Stress-induced changes in hippocampal function. Prog Brain Res. 167: 3-15.
3. Alfarez DN, Karst H, Velzing EH, Joëls M, Krugers HJ. (2008) Opposite effects of glucocorticoid receptor activation on hippocampal CA1 dendritic complexity in chronically stressed and handled animals. Hippocampus. 18(1): 20-8.
4. Joëls M, Karst H, Krugers HJ, Lucassen PJ. (2007) Chronic stress: implications for neuronal morphology, function and neurogenesis. Front Neuroendocrinol. 28(2-3): 72-96. Review.
5. Pu Z, Krugers HJ, Joëls M. (2007) Corticosterone time-dependently modulates beta-adrenergic effects on long-term potentiation in the hippocampal dentate gyrus. Learn Mem. 14(5): 359-67.
6. Joëls M, Krugers HJ. (2007) LTP after stress: up or down? Neural Plast. 93202. Review.
7. Sennvik K, Boekhoorn K, Lasrado R, Terwel D, Verhaeghe S, Korr H, Schmitz C, Tomiyama T, Mori H, Krugers H, Joels M, Ramakers GJ, Lucassen PJ, Van Leuven F. (2007) Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice. FASEB J. 21(9): 2149-61.
8. Krugers HJ, van der Linden S, van Olst E, Alfarez DN, Maslam S, Lucassen PJ, Joëls M. (2007) Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats. Synapse. 61(4): 221-30.
9. Alfarez DN, Wiegert O, Krugers HJ. (2006) Stress, corticosteroid hormones and hippocampal synaptic function. CNS Neurol Disord Drug Targets. (5): 521-9. Review.
10. Krugers HJ, Goltstein PM, van der Linden S, Joëls M. (2006) Blockade of glucocorticoid receptors rapidly restores hippocampal CA1 synaptic plasticity after exposure to chronic stress. Eur J Neurosci. 23(11): 3051-5.
11. Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O, Ramakers GJ, de Vos K, Krugers H, Tomiyama T, Mori H, Joels M, van Leuven F, Lucassen PJ. (2006) Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. J Neurosci. 26(13): 3514-23.
12. Wiegert O, Joëls M, Krugers H. (2006) Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus. Learn Mem. 13(2): 110-3.
13. Joëls M, Pu Z, Wiegert O, Oitzl MS, Krugers HJ. (2006) Learning under stress: how does it work? Trends Cogn Sci. 10(4):152-8. Review.
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