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Education
1961 B.Sc. Mathematics and Physics
1965 Ph.D. Neurophysiology Massachusetts Institute of Technology with Patrick Wall DM 1965-1968 Research Fellow in Physiology
Academic Appointments
1968 Instructor in Physiology
1968-1973 Assistant Professor of
1973-1979 Associate Professor of
1980 Professor of
1980-Present Professor of Neurobiology and Behavior SUNY Stony Brook
1980- Present Professor of Physiology & Biophysics SUNY Stony Brook (Joint Appointment)
1986- 2006 Chair, Dept of Neurobiology and Behavior SUNY, Stony Brook
Concurrent Positions
1969 Research Fellow in Physiology
1976-77 Research Fellow in Anatomy
1989-2004 Adjunct Professor of Physiology,
2006 Visiting Professor Institute for Child Health,
Awards/ Honors 1961 Lt Governor’s Gold Medal,
1965 Elected to Sigma Xi, MIT
1966- 68 NIH Post-doctoral Fellowship
1971-76 Research Career Development Award -NINCDS
1976-77 Josiah Macy, Jr., Foundation Faculty Scholar Award
1988-95 Javits Neuroscience Investigator Award, NINDS
1995-2002 Javits Neuroscience Investigator Award, NINDS
1996 Appointed SUNY Distinguished Professor
External Activities
Leadership positions
1983-89 Editor- in- Chief, Journal of Neurophysiology
1986-90 Council, Society for Neuroscience
1991-92 President, Association of Neuroscience Departments and Programs
1996-7 Treasurer, Society for Neuroscience
1997-8 President, Society for Neuroscience
2007- Chairman of
2007- Board of Directors, Craig Neilsen Foundation
Named/Plenary lectures
1992 Society for Neuroscience, Plenary Lecture
1994 Knight Lecturer, The
1995
1995 American Pain Society, Plenary lecture
1996 Society for Neuroscience, Plenary Lecture
1999 Servier Lecture,
Professional Activities
1975-78 Member, Advisory Panel for Neurobiology, National Science Foundation
1979-81 Member, Neurology B Study Section, NIH
1980-99 Member, Wakeman Award Selection Committee,
1985 Co-organizer, Conference on Strategies for modifying axonal growth, synaptic function, and recovery of neural function after injury to the central nervous system sponsored by National Spinal Cord Injury Association and the Society for Neuroscience
1989-95 Member, Publications Committee, American Physiological Society
1989 Co-organizer, Conference on the Segmental Motor System
1995 Co-organizer, Conference on Presynaptic Inhibition and Neural Control
1995 Co-organizer, Royal Society of London Discussion on Neuroptrophins and sensory neurons: role in development, maintenance and injury
1995-99 Member, Consortium Advisory Panel, Christopher Reeve Paralysis Foundation
1998-2007 Member, Ameritec Award Selection Committee
1997-2003 Scientific Trustee,
2000-2003 Member, Perl Prize Selection Committee,
2000- Member,
2000 Co-organizer, Symposium celebrating the Decade of the Brain
2003- Member, Dana
2004- Member, International Science Advisory Council, Neuroscience
2004-
2008- External Advisory Board,
Various Consultant to funding agencies:
NIH ad hoc member of study sections (IFCN4; Training grant committee; Site visits (
MRC Canada- site visits to
Wellcome Trust (
Various Consultant on research and academic programs at:
University of Florida; Medical College of Pennsylvania; Yale University; University of Texas Medical Branch, Galveston; Centre of Excellence Network on Recovery of Function (Canada); Program in Physiology and Biophysics, University of Washington; Center for Neurobiology, University of Alabama at Birmingham; University of Florida Brain Institute; Wright State University; University of Connecticut, Dept of Physiology and Neurobiology; State University System of Florida, Spinal Cord and Head Injury Programs; Centre de Recherches en Sciences Neurologiques, Université de Montréal
Editorial Boards
Journal of Neurophysiology 1978-1989; 1996-
Journal of Neuroscience 1984-1989
Somatosensory and Motor Research 1988-
Current Opinion in Neurobiology 1990-
News in Physiological Sciences 1994- 1999
Primary Sensory Neuron 1995-2000
Reviews of Physiology, Biochemistry and Pharmacology 1996-2001
Stony Brook activities
Research Areas
Electrophysiology of the Spinal Cord and Sensory Neurons
Cellular Mechanisms of Adjustment after Spinal Injury
Functional Effects of Growth Factors
Pain Mechanisms
Current Research Support
Mechanisms of Plasticity in Neuronal Connections
-NINDS R01 NS 16996 (initially NS 08411 at Duke)
-1969- 2012 (current annual direct costs: $215,000):
Neurotrophins and Spinal Cord Injury
-Christopher Reeve Paralysis Foundation Consortium on Spinal Cord Injury
-2007-2009 (current annual direct costs: $227,000)
Current Teaching assignments
BIO 208, Cell Brain and Mind responsible for 50% of the course (non BIO major undergraduates)
BNB 562, Systems Neuroscience for graduate students: 9 hours of lecture: Course Director
BNB 655 Neuropharmacology for graduate students: 2 hr. lecture on Pain Mechanisms
Current Departmental Assignments
Organizer, Seminar Program
Member, Departmental search committee
Current University activities external to Department of Neurobiology
Member, Library Committee,
Member, Core Committee, Center for Computational Neuroscience
Member, Board for Pre-College and Community Music Programs, Dept. of Music
Recent short term research students (UG, High School,
Yu Chen, Stony Brook undergraduate
Darrell Barker, Medical Student (MD with honors Program)
Andrew Davenport,
Bradley Klein,
Rob Trainer, Resident in Anesthesiology
Research Students in Mendell lab:
Predoctoral Present Position |
|
| Margaret Hollyday Professor (Biology), |
| Richard Weiner Professor (Psychiatry), |
| John Scott Assistant Professor (Family Medicine), |
| Steven Nelson Deceased |
| David Rubin Unknown |
| Tim Cope Professor and Chair (Physiology), |
Predoctoral students, cont.Stony Brook |
| Robert Rose Unknown |
| Richard Traub Associate Prof. of Neurobiology ( |
| Amy Ritter Scientist, Merck, |
| Kavita Peshori Radiologist, |
| James Tonra Scientist, |
| Monicca Shanthanelson Graduate student, Dept. of Neurobiology, |
|
|
Postdoctoral Research fellows |
|
| Richard Carlsen Professor (Human Physiology), UC-Davis (retired) |
| Janice Levitt Research Associate (Neurosurgery), Duke (retired) |
Stony Brook |
| William Collins, III Associate Professor (Neurobiology and Behavior), Stony Brook |
| Marcia Honig Professor (Anatomy and Neurobiology), |
| Matthias Sedivec Professor (Biology), Appalachian State University (retired) |
| Brian Davis Associate Professor (Medicine and Neurobiology), |
| H. Richard Koerber Professor (Neurobiology), |
| Joseph Pierce Assistant Research Professor of Neurology and Neuroscience, Weill/Cornell Medical School
Gary Lewin Group Leader, |
| Alain Rueff Pharmacist, |
| Bradley Seebach Associate Professor, |
| Xiao-Quan Shu Dentist, |
| Victor Arvanian Research Associate Professor, Stony Brook |
| Jeff Petruska Research Assistant Professor, Stony Brook: Appointed Assistant Professor, Dept of Anatomy and Neurobiology, |
| Sandra Garraway Research Associate, Weill/ |
| Vanessa Boyce Postdoctoral Research Associate, Stony Brook |
|
|
| Research Visitors (Duke; Stony Brook) |
| John Munson visitor (from |
| Andrej Niechaj visitor (from |
| Robert Druzinsky visitor from |
|
|
Participation in Meetings, Symposia, etc.
· Aug., 1971, Advanced NATO Study Program in Neuroembryology, Selected Participant,
· Nov., 1972, Workshop on Central Synaptic Transmission, 2nd Neuroscience Meeting, Chairman,
· Nov., 1973, Workshop on Feedback in Motor Control, 3rd Neuroscience Meeting, Invited Speaker,
· Jan., 1974, Winter Conference for Brain Research, Session on Gate Control of Pain, Invited Speaker,
· Nov., 1975, Symposium on Growth, Degeneration and Functional Change in Neurons, 5th Neuroscience Meeting, Invited Discussant,
· 1978, Symposium Sponsored by Hand Society, Invited Lecturer,
· Nov., 1978, Spike Triggered Averaging Symposium, 8th Annual Neuroscience Meeting, Invited Speaker,
· 1979, Fifth Biennial Conference on Regeneration in the Central Nervous System sponsored by National Paraplegia Foundation and Society for Neuroscience, Invited Speaker, Ft. Lauderdale, Florida.
· 1980, Symposium on Mechanisms of Recovery following Lesions in Sensorimotor Systems organized by Profs. W. Precht & H. Flohr, Invited Speaker,
· Aug., 1980, Symposium on Mechanisms of Monosynaptic Transmission in the Spinal Cord, IUPS Congress, Invited Speaker,
· Oct., 1980, Symposium to Celebrate 25th Anniversary of Institute of Neurological Sciences, Invited Speaker,
· Nov., 1981, Symposium on Motor Unit Recruitment, UCLA, Invited Speaker
· Dec., 1981, Dahlem Conference on CNS Regeneration, Invited Participant, West
· 1982, Foundation of Scientific Neurology, American Neurological Association, Invited Lecturer,
· 1982, Neural Trauma Meeting, Invited Lecturer,
· August, 1983, IUPS Satellite Symposium on Spinal Cord,
· Sept., 1983, IUPS Satellite Symposium on Synaptic Transmission,
· Nov., 1983, Society for Neuroscience Satellite Symposium on Recruitment Mechanisms,
· June, 1984, Fernstrom Symposium on Brain Transplantation, Invited Participant,
· August, 1984, IUPS Meeting, Session on Spinal Cord Regional Physiology, Invited Speaker,
· Sept., 1984, International Symposium on Development and Plasticity of the Mammalian Spinal Cord, Invited Speaker,
· Jan., 1985, IBRO Swiss Meeting,
· January, 1985, Winter Conference for Brain Research, Panel on Transmission at Ia/motoneuron synapses, Vail,
· May, 1985, National Spinal Cord Injury Association, 7th Biennial Conference on CNS Regeneration, Organizer and Conference Chairman, Fort Lauderdale, Fl.
· Nov., 1985, VA-PVA CNS Regeneration Meeting,
· July, 1986, International Congress on Neuromuscular Diseases,
· July, 1986, Meeting on Effects of Injury on Somatosensory Systems, Timberline,
· Aug., 1987, 5th World Congress on
· Aug., 1987, IBRO Meeting,
· Sept., 1987, Fall Retreat of the Neuroscience Training Program,
· Jan., 1988, Winter Conference for Brain Research,
· May, 1988, Symposium on Spasticity,
· Nov., 1988, Symposium on Spinal Cord Plasticity,
· Nov., 1988, Symposium on Development of Functional Heterogeneity Among Sensory Neurons, Society for Neuroscience,
· January, 1989, Winter Conference for Brain Research, Snowbird,
· May, 1989, Symposium in honour of Professor P.D., Wall, F.R.S., Woods Hole, Mass, Invited Speaker
· Oct., 1989, Symposium on The Segmental Motor System,
· Jan, 1990, Panel on Plasticity at the Ia synapse: New use for a classic model.
· April 1990, Session on Pain in Childhood, International Association for the Study of Pain,
· June 1990, International Society of Developmental Neurobiology Meeting,
· Sept., 1990, Symposium on Motoneuron Plasticity,
· Jan., 1991, Panel on quantal transmission at central synapses, Winter Conference for Brain Research, Vail CO, Invited Speaker
· May 1991, First Annual Meeting of Canadian Network on Recovery of Function,
· Aug., 1991, Workshop on Computational properties of motoneurons, IBRO meeting,.
· Sept., 1991, Symposium on Formation and Regeneration of Nerve Connections,
· Dec., 1991, Symposium on Artificial and Natural Intelligence.
· June 1992, Spring Symposium on Neuronal Plasticity. Neuroscience Program,
· Oct., 1992, Society for Neuroscience meeting,
· March 1993, Symposium on Sensory Ganglion Cells,
· May 1993, Symposium on Peripheral Inflammation held at the Royal Society,
· Aug., 1993, Nerve Growth Factor and Pain, International Association for the Study of Pain meeting, Paris, France, Invited Organizer and Speaker
· Feb., 1994, US- Mexico Research Development Workshop,
· June 1994, Third International Congress on Pediatric Pain,
· July, 1994, Symposium on Function of Alpha and Gamma Motoneurons,
· May 1995, 10th Annual Applied Neural Control Research Day,
· June 1995, Symposium on Presynaptic Inhibition,
· June 1995, Symposium on Sensorimotor Mechanisms,
· July, 1995, U.K. Physiological Society, Sensorimotor Control Interest Group, Plenary lecture
· Sept., 1995, Neurotrophins and Sensory Neurones, The Royal Society,
· Nov., 1995, American Pain Society,
· May 1996, Canadian Network Centre of Excellence on Recovery of Function, Symposium on Inflammatory Pain,
· Aug., 1996, International Association for the Study of Pain, Symposium on neuronal sprouting in the spinal cord, Vancouver, Canada, Invited Speaker
· Sept., 1996, NIH Conference on Spinal Cord Injury,
· Nov., 1996, Society for Neuroscience,
· Nov., 1997, NIH Conference on Pain,
· Nov., 1997, Neuroscience Symposium on Spinal Cord and Nerve Injury: Models and Mechanisms.
· March 1998, Symposium on Motor Function and the Spinal cord,
· April, 1998, Symposium on Information Processing in the Axonal Tree.
· July 1998, International Congress of Pharmacology,
· Dec., 1998, Colloquium on “The Neurobiology of Pain” National Academy of Sciences,
· June, 1999, Gordon Conference on NGF,
· Sept., 1999, ASPET- Ray Fuller Symposium on the Cellular Mechanisms and Novel Strategies for Pain control,
· Nov., 1999, International Bladder Symposium,
· May, 2000, NGF 2000,
· Nov. 2000, Journal of Physiology Symposium,
· Jan., 2001, NIH Conference on Spinal Cord Injury,
· April, 2001, NIH Spinal Cord Symposium in honor of Robert E. Burke,
· April, 2001, American Pain Society, Symposium on Neurotrophins and Sensitization of Nociceptors,
· Sept., 2001, Spinal Cord Injury: mechanisms of spinal autonomic reflexes and their plasticity.
· Sept., 2001, Segerfalk Symposium: Spinal cord function, plasticity and repair,
· June, 2002, Symposium on Motoneurons:
· March, 2003, American Pain Society, Symposium, Bumps, Burns and Bruises: Ion channels underlying the response to physical stimuli. Chicago, Invited Speaker.
· April, 2004, Spring Pain Research Conference,
· August, 2004 IV Congreso Internacional de Rehabilitacion
· September, 2005 Symposium on Synaptic Transmission in honor of Stephen Redman,
· September, 2005 Retreat of the Groupe de Recherche sur le Système Nerveux Centrale, Université de Montréal, Orford, Québec, Invited Keynote Speaker
· April, 2006, ASPET Symposium on Therapeutic Effects of Nerve Growth Factor, San Francisco, CA, Invited speaker
· April, 2006, Spring Pain Research Conference,
· April 2007, Banbury Conference,
· September 2007, Joint Spinal Cord Meeting: State of the Art in Spinal Cord Injury Research and Clinical Application,
· January, 2008, Spinal Cord Injury Symposium, NY Academy of Science, Organizing Committee and participant.
· May, 2008, Spinal Cord Injury Symposium, Christopher and Dana Reeve Foundation,
· May, 2008, Symposium on “Development and Function of Somatosensation and Pain”
· June, 2008, 2008 International Conference of Pain Research and Control,
Departmental seminars- about 90 seminars in
Refereed Papers
1. Mendell LM and Wall PD (1964) Presynaptic facilitation: A role for fine afferent fibers. J.Physiol. 174: 274- 294.
2. Mendell LM and Wall PD (1965) Response of single dorsal cord cells to peripheral cutaneous unmyelinated fibers. Nature 206: 97- 99.
3. Mendell LM (1966) Physiological properties of unmyelinated projection to the spinal cord. Exp. Neurol. 16: 316- 324.
4. Mendell LM and Henneman E (1968) Terminals of single Ia fibers: Distribution within a pool of 300 homonymous motoneurons. Science 160: 96-98.
5. Mendell LM (1970) Positive dorsal root potentials produced by stimulation of small diameter muscle afferents. Brain Res. 18: 375- 379.
6. Mendell LM and Henneman E (1971) Terminals on single Ia fibers: Location, density and distribution within a pool of 300 homonymous motoneurons. J. Neurophysiol. 34: 171-187.
7. Mendell LM (1972) Properties and distribution of peripherally evoked presynaptic hyperpolarization in cat lumbar spinal cord. J. Physiol. 226: 769-792.
8. Mendell LM (1973) Two negative dorsal root potentials evoke a positive dorsal root potential. Brain Res. 55: 198-202.
9. Mendell LM, Munson JB and Scott JG (1974) Connectivity changes of Ia afferent fibers on axotomized motoneurons. Brain Res. 73: 338-342.
10. Mendell LM and Scott JG (1975) The effect of peripheral nerve cross union on connections of single Ia fibers to motoneurons. Exp. Brain Res. 22: 221-234.
11. Hollyday MA and Mendell LM (1975) Area specific reflexes from normal and supernumerary limbs of Xenopus laevis. J. Comp. Neurol. 162: 205-220.
12. Mendell LM and
13. Mendell LM, Munson JB and Scott JG (1976) Alterations of synapses on axotomized motoneurons. J. Physiol. 255: 67-79.
14. Hollyday MA and Mendell LM (1976) Analysis of moving supernumerary limbs of Xenopus laevis. Exp. Neur. 51: 316-329.
15. Scott JG and Mendell LM (1976) Individual EPSPs produced by single triceps surae Ia afferent fibers in homonymous and heteronymous motoneurons. J. Neurophysiol 39: 679-692.
16. Carlsen RC, Cruce WLR and Mendell LM (1976) The effect of axotomy on root potential in the frog spinal cord. Brain Res. 108: 418-422.
17. Carlsen RC and Mendell LM (1977) A comparison of the reflex organization of thoracic and lumbar segments in the frog spinal cord. Brain Res. 124: 415-426.
18. Nelson SG and Mendell LM (1978) Projection of single knee flexor fibers to homonymous and heteronymous motoneurons. J. Neurophysiol. 41: 778-787.
19. Mendell LM, Sassoon EM and Wall PD (1978) Cutaneous projection to dorsal horn interneurons and functional changes following deafferentation. J. Physiol. 285: 299-310.
20. Collatos TC, Niechaj A, Nelson SG and Mendell LM (1979) Fluctuations in time of onset of Ia-motoneuron EPSPs in the cat. Brain Res. 160: 514-518.
21. Nelson SG and Mendell LM (1979) Enhancement in Ia-motoneuron synaptic transmission caudal to chronic spinal cord transection. J. Neurophysiol. 42: 642-654.
22. Nelson SG, Collatos TC, Niechaj A and Mendell LM (1979) Immediate increase in Ia-motoneuron synaptic transmission caudal to spinal cord transection. J. Neurophysiol. 42: 655-664.
23. Cope TC, Nelson SG and Mendell LM (1980) Factors outside the neuraxis mediate the "acute" increase in EPSP amplitude caudal to spinal cord transection. J. Neurophysiol. 44: 174-183.
24. Rubin DI and Mendell LM (1980) Location of motoneurons supplying individual muscles in normal and grafted superumerary limbs of Xenopus laevis. J. Comp. Neurol. 192: 703-715.
25. Cope TC, Nelson SG and Mendell LM (1980) Selectivity in synaptic changes to acute spinal cord transection. Neurosci. Lett. 20: 289-294.
26. Cope TC and Mendell LM (1982) Parallel fluctuations of EPSP amplitude and rise time with latency at single Ia fiber- motoneuron connections in the cat. J. Neurophysiol. 47: 455-468.
27. Cope TC and Mendell LM (1982) Distribution of EPSP latency at different group Ia fiber-motoneuron connections. J. Neurophysiol. 47: 469-478.
28. Honig M, Collins WF, III and Mendell LM (1983) Alpha- Motoneuron EPSPs exhibit different frequency sensitivities to single Ia-afferent fiber stimulation. J. Neurophysiol. 49: 886- 901.
29. Sedivec MJ, Ovelmen-Levitt J, Karp R and Mendell LM (1983) Increase in nociceptive input to spinocervical tract neurons following chronic partial deafferentation. J. Neurosci. 3: 1511- 1519.
30. Mendell LM (1984) Modifiability of spinal synapses. Physiological Reviews 64: 200-324.
31. Collins WF, III, Honig MG and Mendell LM (1984) Heterogeneity of group Ia synapses on homonymous alpha- motoneurons as revealed by high frequency stimulation. J. Neurophysiol. 52: 980-993.
32. Davis BM, Collins WF, III and Mendell LM (1985) Potentiation of transmsssion at Ia-motoneuron connection induced by repeated bursts of afferent activity. J. Neurophysiol. 54: 1541-1552.
33.
34. Sedivec MJ, Capowski J. and Mendell LM (1986) Morphology of HRP-injected spinocervical tract neurons: effects of dorsal rhizotomy. J. Neurosci. 6: 661-672.
35. Collins WF, III, Mendell LM and Munson JB (1986) On the specificity of sensory reinnervation of cat skeletal muscle. J. Physiol. 375: 587-609.
36. Collins WF, III, Davis BM and Mendell LM (1986) Amplitude modulation of EPSPs in motoneurons in response to a frequency modulated train in single Ia afferent fibers. J. Neurosci. 6: 1463-1468.
37. Traub RJ, Sedivec MJ and Mendell, LM (1986) The rostral projection of small diameter primary afferents in Lissauer's Tract. Brain Res. 399: 185-189.
38. Davis BM, Druzinsky RE and Mendell LM (1987) Distribution of potentiation following short high frequency bursts to motoneurons of different rheobase. Exptl. Brain Res. 65: 639-648.
39. Traub RJ and Mendell LM (1988) Spinal projection of individual small afferent fibers. J. Neurophysiol. 59: 41-55.
40. Collins WF III, Davis BM and Mendell LM (1988) Modulation of EPSP amplitude during high frequency stimulation depends on the correlation between potentiation, depression and facilitation. Brain Res. 442: 161-165.
41. Koerber HR, Druzinsky RE and Mendell LM (1988) Properties of somata of spinal dorsal root ganglion cells differ according to peripheral receptor innervated. J. Neurophysiol. 60: 1584-1596.
42. Koerber HR and Mendell LM (1988) Functional specialization of central projections from identified primary afferent fibers. J.Neurophysiol. 60: 1597-1614.
43. Koerber HR, Seymour AW, and Mendell LM (1989) Mismatches between peripheral receptor type and central projections after peripheral nerve regeneration. Neurosci. Lett. 99:67-72.
44. Koerber HR, Brown PB, and Mendell LM (1990) Correlation of monosynaptic field potentials evoked by single action potentials in single primary afferent axons and their bouton distributions in the dorsal horn. J.Comp. Neurol. 294: 133-144.
45. Koerber HR and Mendell LM (1991) Modulation of synaptic transmission at Ia afferent fiber connections on motoneurons during high frequency stimulation: Role of postsynaptic target. J. Neurophysiol. 65: 590-597.
46. Solodkin M, Jimenez I, Collins WF III, Mendell LM and Rudomin P (1991) Interaction of baseline synaptic noise and ia epsps: evidence for appreciable negative correlation under physiological conditions. J. Neurophysiol. 65: 927-945.
47. Ritter AM, Lewin G, Kremer N and Mendell LM (1991) Nerve growth factor is required for the development of myelinated nociceptors. Nature 350: 500-502.
48. Koerber HR and Mendell LM (1991) Modulation of synaptic transmission at Ia afferent fiber connections on motoneurons during high frequency stimulation: Dependence on motor task. J. Neurophysiol.65: 1313-1320.
49. Koerber HR, Seymour AW and Mendell LM (1991) Tuning of spinal networks to frequency components of spike trains in individual afferents. J. Neurosci. 11: 3178- 3187.
50. Lewin G, Ritter AM and Mendell LM (1992) On the role of nerve growth factor in the development of myelinated nociceptors. J. Neurosci. 12: 1896- 1905.
51. Ritter AM and Mendell LM (1992) The somal membrane properties of physiologically identified sensory neurons in the rat: Effects of nerve growth factor. J. Neurophysiol. 68: 2033- 2041.
52. Lewin GR, Lisney SJW and Mendell LM (1992) Neonatal NGF treatment reduces the A-delta and C-fiber evoked vasodilator response in rat skin: evidence that nociceptors mediate antidromic vasodilatation. Eur. J. Neurosci. 4: 1213- 1218.
53. Lewin GR and Mendell LM (1993) Nerve growth factor and nociception. Trends in Neurosciences 16: 353- 359.
54. Lewin GR, Ritter AM and Mendell LM (1993) Nerve growth factor induced hyperalgesia in the neonatal and adult rat. J. Neurosci. 13: 2136- 2149.
55. Pierce J and Mendell LM (1993) Quantitative ultrastructure of Ia boutons in the ventral horn: Scaling and positional relationships. J. Neurosci.13: 4748- 4763.
56. Davis BM, Lewin GR, Mendell LM, Jones ME and Albers KM (1993) Altered expression of nerve growth factor in the skin of transgenic mice leads to profound changes in response to mechanical stimuli. Neuroscience 56: 789- 792.
57. Mendell LM, Collins WF, III and Munson JB (1994) Retrograde determination of motoneuron properties and their synaptic input. J. Neurobiol. 25: 707- 721.
58. Lewin GR and Mendell LM (1994) Regulation of cutaneous C-fiber nociceptors by nerve growth factor in the developing rat. J. Neurophysiol. 71: 941- 949.
59. Koerber HR, Mirnics K, Brown PB and Mendell LM (1994) Central sprouting and functional plasticity of regenerated primary afferents. J. Neurosci. 14: 3655- 3671.
60. Lewin GR, Rueff A and Mendell LM (1994) Peripheral and central mechanisms of NGF- induced hyperalgesia. Eur. J. Neurosci. 6: 1903- 1912.
61. Johnson RD, Taylor JS, Mendell LM and Munson JB (1995) Rescue of motoneuron and afferent function in cats by regeneration into skin.
62. Mendell LM, Taylor JS,
63. Koerber HR, Mirnics K and Mendell LM (1995) Properties of regenerated primary afferents and their functional connections. J.Neurophysiol. 73: 693- 702.
64. Rueff A, Dawson AJIR and Mendell LM (1996) Characteristics of nerve growth factor induced hyperalgesia in adult rats: dependence on enhanced bradykinin-1 receptor activity but not neurokinin-1 receptor activation. Pain 66: 359- 372.
65. Lewin GR and Mendell LM (1996) Maintenance of modality specific connections in the spinal cord after neonatal NGF deprivation. Eur. J. Neurosci. 8: 1677- 1684.
66. Seebach BS and Mendell, LM (1996) Maturation in properties of motoneurons and segmental input in the neonatal rat. J. Neurophysiol. 76: 3875- 3885.
67. Rueff A and Mendell LM (1996) Nerve growth factor and NT-5 induce increased thermal sensitivity of cutaneous nociceptors in vitro. J. Neurophysiol. 76: 3593- 3596.
68. Munson JB,
69. Munson JB, Johnson, RD and Mendell LM (1997) NT-3 increases amplitude of EPSPs produced by axotomized group Ia afferents. J. Neurophysiol. 77: 2209- 2212.
70. Tonra JR and Mendell LM (1997) Rabbit IgG distribution in skin, spinal cord and DRG following systemic injection in rat. J. Neuroimmunol 80: 97-105.
71. Peshori KR, Collins WF, III and Mendell LM (1998) Mechanisms of frequency-dependent EPSP amplitude modulation at the rat
72. Tonra JR and Mendell LM (1998) The effects of postnatal anti-NGF on the development of CGRP-IR neurons. J. Comp. Neurol. 392: 489- 498.
73. Shu X, Llinas A. and Mendell LM (1999) Effects of trkB and trkC neurotrophin receptor agonists on thermal nociception: a behavioural and electrophysiological study. Pain 80: 463- 470.
74. Seebach BS, Arvanov V and Mendell, LM (1999) Neurotrophin influence on the development of segmental reflexes in the rat. J. Neurophysiol. 81: 2398- 2405
75. Mendell LM,
76. Shu X and Mendell LM (1999) Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin. Neurosci. Lett. 274:159-162.
77. Arvanov VL, Seebach BS and Mendell, LM (2000) NT-3 evokes an LTP- like facilitation of AMPA/Kainate- mediated synaptic transmission in the neonatal rat spinal cord. J. Neurophysiol. 84: 752- 758.
78. Arvanov VL and Mendell LM (2001) Removal of NMDA receptor Mg2+ block extends the action of neurotrophin-3 on synaptic transmission in neonatal rat motoneurons. J. Neurophysiol. 86: 123-129
79. Mendell LM, Munson JB and Arvanian VL (2001) Neurotrophins and synaptic plasticity in the mammalian spinal cord. J Physiol 533: 91-97
80. Shu X and Mendell LM (2001) Acute sensitization by NGF of the response of small- diameter sensory neurons to capsaicin. J. Neurophysiol. 86: 2931- 2938.
81. Arvanian VL and Mendell L.M (2001) Acute modulation of synaptic transmission to motoneurons by BDNF in the neonatal rat spinal cord. Eur. J. Neurosci.14: 1800- 1808.
82. Mendell LM and Arvanian VL (2002) Diversity of neurotrophin action in the postnatal spinal cord. Brain Res. Reviews 40: 230-239.
83. Mendell LM (2002) Does NGF binding to p75 and trkA receptors activate independent signaling pathways to sensitize nociceptors? J. Physiol. (Perspective) 544, P. 333.
84. Galoyan SM, Petruska JC and Mendell LM (2003) Mechanisms of sensitization of the response of single DRG cells from adult rat to noxious heat Eur. J. Neurosci. 18: 535- 541
85. Arvanian VL, Horner PJ, Gage FH and Mendell LM (2003) Intrathecal neurotrophin-3-secreting fibroblasts strengthen synaptic connections to motoneurons in the neonatal rat. J. Neurosci.23: 8706-8712.
86. Garraway S, Petruska JC and Mendell LM (2003) BDNF modulates dorsal root evoked synaptic currents in substantia gelatinosa neurons. Eur. J. Neurosci. 18: 2467-2476.
87. Arvanian VL, Bowers WJ, Petruska JC, Manuzon H, Narrow WC, Motin V, Federoff HJ and Mendell LM (2004) Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA/kainate responses in maturing rat motoneurons J. Neurophysiol .92: 2394- 2404.
88. Zhu W, Galoyan SM, Petruska JC,
89. Arvanian VL, Motin V and Mendell LM (2005) Comparison of metabotropic glutamate receptor responses at segmental and descending inputs to motoneurons in neonatal rat spinal cord. J. Pharm. Exp. Ther. 312: 669-77.
90. Garraway SM, Anderson AJ and Mendell LM (2005) BDNF-induced facilitation of afferent evoked responses in lamina II neurons is reduced following neonatal spinal cord contusion injury. J. Neurophysiol. 94: 1798- 1804.
91. Arvanian VL, Bowers WJ, Anderson AJ, Horner PJ, Federoff HJ and Mendell LM (2006) Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat Exp. Neurol. 197: 347- 352.
92. Arvanian VL, Manuzon H, Davenport M, Bushell G, Mendell LM and Robinson JK (2006) Combined treatment with neurotrophin-3 and LSD facilitates behavioral recovery from double- hemisection spinal injury in neonatal rats. J. Neurotrauma 23: 66-74.
93. Garraway SM and Mendell LM (2007) Spinal cord transection enhances afferent- evoked inhibition in lamina II neurons and abolishes BDNF- induced facilitation of their sensory input. J. Neurotrauma 24: 379- 390.
94. Petruska JC, Ichiyama RM, Crown ED, Tansey KE, Roy RR Edgerton VR and Mendell LM (2007) Changes in motoneuron properties and synaptic inputs related to step training following spinal cord transection in rats. J. Neuroscience 27: 4460- 4471
95. Tan AM, Petruska JC, Mendell LM and Levine JM (2007) Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state. Exp. Neurol. 206:257-68.
Invited reviews, Chapters
1. Mendell LM and Hollyday MA (1976) Spinal reflexes in anurans with an altered periphery. In R. Llinas, and W. Precht (Eds.), Handbook of Frog Neurobiology,
2. Mendell LM and Henneman E (1980) Principles governing distribution and effect of input to motoneuron pools. In V.B. Mountcastle (Ed.), Ch. 27 of 14th Edition of Medical Physiology textbook, C.V. Mosby, St. Louis.
3. Edgerton VR, Smith LA, Eldred E, Cope TC and Mendell LM (1980) Muscle and motor unit properties of exercised and non- exercised chronic spinal cats. In D. Pette (Ed.), Plasticity of Muscle,
4. Mendell LM and Cope TC (1981) Fluctuations in Group Ia EPSPs: Consequences for mechanisms of transmitter release and measured parameters of averaged EPSPs. XXVIIIth International Congress of Physiological Sciences.
5. Henneman E and Mendell LM (1981) Organization of motor pool and its inputs. In V. Brooks (Ed.), Motor Control. Handbook of Physiology, American Physiological Society.
6. Mendell LM, Nelson SG and Cope TC (1981) Functional changes caudal to spinal cord transection. In W. Precht and H. Flohr (Eds.), Mechanisms of Recovery Following Lesions in Sensorimotor Systems. Springer Verlag.
7. Sedivec MJ, Ovelmen-Levitt J, and Mendell LM (1981) Changes in modality convergence in cells of the partially deafferented dorsal horn. In A.G. Brown, M. Rethelyi (Eds.). Spinal Cord Sensation. Scottish Academic Press, pp. 329-330.
8. Mendell LM, Cope TC and Nelson SG (1982) Plasticity of the monosynaptic pathway to motoneurons. In P. Strick, M. Goldberger (Eds.), Changing Concepts of the Nervous System. Proceedings of the First Institute of Neurological Sciences Symposium in Neurobiology at
9. Mendell LM (1982) Temporal changes after spinal cord injury. In J.G. Nicholls (Ed.), Repair and Regeneration of the Nervous System. Dahlem Workshop Report, Springer-Verlag, 255-268.
10. Mendell LM and Sedivec MJ (1985) Physiological consequences of dorsal rhizotomy on the receptive field organization of dorsal horn neurons. In H.R. Winn, R. Rimel, J.A. Jane (Eds.) Synaptic Reorganization in Spinal Cord Following Injury. Raven Press,
11. Veraa RP and Mendell LM (1986) Strategies for modifying axonal growth, synaptic function and recovery of neural function after injury to the Central Nervous System: A Conference Report. Exp. Neurol. 93: 1-56.
12. Mendell LM, Sedivec MJ, and Traub RJ (1986) Response of an identified population of spinal cord neurons to partial deafferentation. In: Development and Plasticity of the Mammalian Spinal Cord. e.d. M. Goldberger, A. Gorio, M. Murray. Liviana Press;
13. Mendell LM, Munson JB and Collins WF, III (1987) Changes in peripheral and central axonal projections following muscle nerve transection. Progress in Brain Res. ed. F.J. Seil, E. Herbert and B.M. Carlson. 71: 231-237. Elsevier.
14. Mendell LM, Koerber HR and Traub RJ (1987) The spared root preparation: evidence for selective changes of projections from surviving fibers. In: Effects of Injury on Somatosensory Systems ed. L.M. Pubols, B. Sessle. Alan R. Liss, Inc.
15. Mendell LM (1987) Physiological aspects of synaptic plasticity. In: Physiological Basis for Functional Recovery in Neurological Disease ed. S. G. Waxman. Raven Press.
16. Munson JB, Collins WF, III and Mendell LM (1988) Reinnervation of muscle spindles by groups Ia and Ib fibers is consistent with specificity in the reinnervation process. In: The Current Status of Peripheral Nerve Regeneration ed. Tessa Gordon. Alan R. Liss, Inc., p. 259-268.
17. Mendell LM (1989) Central Partitioning may be altered during high frequency activation of the Ia-motoneuron connection. Behavioral and Brain Sciences. 12: 665-666 (Invited Commentary).
18. Mendell LM, Collins WF, III and Koerber HR (1990) How are Ia synapses distributed on spinal motoneurons to permit orderly recruitment? In: The Segmental Motor System ed. M.D. Binder and L.M. Mendell.
19. Mendell LM (1990) Somatic spikes of sensory neurons may provide a better sorting criterion than the autonomic/somatic subdivision. Behavioral and Brain Sciences 13: 312-313 (Invited Commentary).
20. Mendell LM, Peshori KR, Pierce J, Koerber HR and Collins WF, III (1991) Short term plasticity at Ia connections on motoneurons: physiological and functional implications. In: Motoneuronal Plasticity, ed. A. Wernig. Restorative Neurology 5, Elsevier.
21. Mendell, LM and Lewin GR (1992) Removing constraints on neural sprouting. Current Biology 2: 259- 261.
22. Koerber HR and Mendell LM (1992) Functional heterogeneity of dorsal root ganglion cells. In: Development and Function of the Dorsal Root Ganglion, ed. S.A.Scott.
23. Mendell LM and Koerber HR (1993) Architecture of sensory fiber projections: implications for neuronal specificity in the spinal cord. In: The Formation and Regeneration of Nerve Connections. ed. S. Sharma and J. Fawcett. Birkhauser,
24. Ritter AM, Lewin GR and Mendell LM (1993) Regulation of myelinated nociceptor function by nerve growth factor in neonatal and adult rats. Brain Res. Bull. 30: 245- 249.
25. Mendell LM and Koerber HR (1993) Neural processing of impulse trains from sensory receptors. In: Natural and Artificial Intelligence: A Meeting between Neuroscience and Artificial Intelligence. ed. Rudomin, P., Arbib, M. A. and Cervantes-Perez, F. Research Notes in Neural Computing 4.
26. Mendell LM (1994) Diversity of somatic spikes in dorsal root ganglion cells: implications for development, function and plasticity. In: Cellular Mechanisms of Sensory Processing, ed. L. Urban, NATO ASI Series, Vol H 79, Springer- Verlag Berlin Heidelberg.
28. Mendell LM (1995) Synaptic differentiation on type identified motoneurones. In: Alpha and Gamma Motor Systems. ed. A. Taylor, M.H. Gladden and R. Durbaba. Plenum.
29. Rueff A and Mendell LM (1996) Nerve growth factor and inflammatory pain. In: IASP Newsletter January/February issue. Technical Corner.
30. Mendell LM (1996) Development of nociceptor phenotype: role of NGF. In: Neurobiology of Nociceptors. ed. F. Cervero, C. Belmonte.
31. Mendell LM (1996) Neurotrophins and sensory neurons: role in development, maintenance and injury. A thematic summary. Phil. Trans. R. Soc. Lond. B. 351: 463- 467.
32. Daly JJ, Marsolais EB, Mendell LM, Rymer WZ, Stefanovska A, Wolpaw JR and Kantor C. (1996) Therapeutic neural effects of electrical stimulation. IEEE Transactions on Rehabilitation Engineering. 4: 218-30.
33. Mendell LM (1998) The physiology of the ia afferent and its synapses: observations and speculations on the functional role of presynaptic inhibition. In: Presynaptic Inhibition and Neural Control, ed. P. Rudomin, R. Romo and L.M. Mendell.
34. Mendell LM and Munson JB (1999) Retrograde effects on transmission at the Ia/ motoneuron synapse during high frequency activation. J. Physiol. (
35. Shu X and Mendell LM (1999) Neurotrophins and hyperalgesia. PNAS (Suppl.) 96:7693-7696.
36. Mendell LM, Albers KM and Davis BM (1999) Neurotrophins, nociceptors and pain. Microscopy Research and Technique. 45: 252-261.
37. Mendell LM (1999) Neurotrophin action on sensory neurons in adults: An extension of the Neurotrophic Hypothesis. Pain Supplement 6: S127-S132.
38. Munson JB,
39. Jones EG and Mendell LM. (1999) Assessing the decade of the brain. Science. 284:739.
40. Mendell LM (2002) Peripheral neurotrophic factors and pain. In: Pain: Current Understanding, Emerging Therapies and Novel Approaches to Drug discovery. Eds. C. Bountra, Munglani, R. and Schmidt, W.K. Marcel Dekker
41. Mendell LM (2002) Nociceptors. In: Encyclopedia of the Human Brain. Ed. V.S. Ramachandran. Academic Press.
42. Petruska, JC and Mendell, LM (2004) The many functions of nerve growth factor: multiple actions on nociceptors. Neurosci. Lett 361: 168-171.
43. Levine JM and Mendell LM (2005) Trophic factors and their influence on regeneration. In: Textbook of Neural Repair and Regeneration. Ed: M. Selzer, S. Clarke, L.G. Cohen, P.W. Duncan and F.H. Gage.
44. Mendell LM (2005) The size principle: a rule describing the recruitment of motoneurons. J Neurophysiol. 93:3024-3026.
45. Mendell LM (2007) ‘Nerve Growth Factor (NGF), Sensitizing action on nociceptors. In: Encyclopedia of Pain (ed. RF Schmidt and WD Willis) Springer
46. Petruska JC and Mendell LM (In Press) Nerve Growth Factor. In: Encyclopedia of Neuroscience. Elsevier
47. Mendell LM (In Press) Neurotrophins and pain. In The Senses (Pain), ed. C. Bushnell and A. Basbaum. Elsevier
Edited Volumes
Binder, M.D. and Mendell, L.M. (eds.) (1990) The Segmental Motor System.
McMahon, S.B., Mendell, L.M., Phillips, H.S. and Wall, P.D. (eds.) (1996) Neurotrophins and sensory neurones: role in development, maintenance and injury. Philosophical Transactions: Biological Sciences. Vol. 351, Pp. 361- 467.
Rudomin, P., Romo, R., and Mendell, L.M.(eds) (1998) Presynaptic Inhibition and Neural Control, Oxford University Press,
Basbaum, A.I., Dubner, R., Fields, H.L., McMahon, S.B., Mendell, L.M. and Woolf, C.J. (eds.) (1999) A Tribute to Patrick D. Wall. Pain, Suppl. 6.
Jones, E.G., Mendell, L.M. and Lees, G.V. (eds.) (2000) Neuroscience 2000: A New Era of Discovery. Neurobiology of Disease, vol. 7.
