CURRICULUM VITÆ

 

Personal Information:

Present Academic Rank and Title:                                      Assistant Professor

Name:                                                                                     W. Daniel Tracey, Ph.D.

 

Citizen of:                                                                              USA

 

Education/Training:

                                    Institution                                            Date (Year)                 Degree

 

College                        State University of                               1991                            B.A.
                                    New York at Buffalo

 

Graduate or                 Florida International University          1994                            M.S.

Professional

School                         State University of New York             1999                            Ph.D.
                                    at Stony Brook

Postdoctoral                California Institute of Technology      1999-2004                  

 

Positions:

Institution/Department                         Position/Title                                      Dates

Duke University Medical Center/ Anesthesiology      Assistant Professor     8/04- Present

Duke University Medical Center/ Cell Biology          Assistant Professor     8/04- Present

Duke University Medical Center/ Neurobiology         Assistant Professor     8/04- Present

 

Honors:

1985    New York State Regents Scholarship

1998    Sigma Xi Excellence in Research Award for: “A Xenopus homologue of aml-1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood” and “Quantitative analysis of gene function in the Drosophila embryo.”

1999    Institute for Cell and Developmental Biology Excellence in Graduate Research Award State University of New York at Stony Brook.

2000    NIH Postdoctoral National Research Service Award (NRSA) declined.

2000 – 2003    Damon Runyon Fellow  (1/2000-1/2003) “Genetic analysis of nociception and pain in Drosophila.”

2000 – 2004    W. M. Keck Discovery Fund Award  (3/2000-2004) "Genetic  analysis  of  nociception and pain in Drosophila.” with Seymour Benzer $166, 000 for research.

2003    “painless, a Drosophila gene essential for nociception.” Named outstanding research paper Faculty of 1000 website.

2005 – 2007    Alfred P. Sloan Research Fellowship in Neuroscience, $45,000 for research from the Alfred P. Sloan Foundation.

2006-2009  Whitehall Foundation “Genetic analysis of nociception in Drosophila” $225,000. 

 

Peer-reviewed primary publications:

1. Tracey WD , Pepling ME, Horb ME, Thomsen GH, Gergen JP. A Xenopus homologue of aml-1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood. Development. 1998;125(8):1371-1380.

2. Tracey WD, Ning X, Klinger M, Kramer SG, Gergen JP . Quantitative analysis of gene function in the Drosophila embryo. Genetics. 2000;154(1):273-84.

3. Wheeler JC, VanderZwan C, Xu X, Swantek D, Tracey WD, Gergen JP. Distinct in vivo requirements for establishment versus maintenance of transcriptional repression. Nat Genet. 2002;32(1):206-10.

4.     Vander Zwan CJ, Wheeler JC, Li LH, Tracey WD, Gergen JP. A DNA-binding-independent pathway of repression by the Drosophila Runt protein. Blood Cells Mol Dis. 2003;30(2):207-22.

5.     Tracey WD, Wilson RI, Laurent G, Benzer S. painless, a Drosophila gene essential for nociception. Cell. 2003;113(2):261-73.

6.     Al-Anzi B, Tracey WD, Benzer S. Response of Drosophila to wasabi is mediated by painless, the fly homolog of mammalian TRPA1/ANKTM1. Current Biology.
2006;16:1-7.

7.     Hwang R, Zhong L, Xu Y, Johnson T, Zhang F, Deisseroth K, Tracey WD.  Nociceptive neurons protect Drosophila larvae from parasitoid wasps.  Current Biology 2007 (in press) Published online Nov 29. 

Other publications:

1. Tracey WD, Speck NA. Potential roles for RUNX1 and its orthologs in determining hematopoietic cell fate. Semin Cell Dev Biol. 2000;11(5):337-42.

2. Goodman MB, Lumpkin EA, Ricci A, Tracey WD, Kernan M, Nicolson T. Molecules and mechanisms of mechanotransduction. J Neurosci. 2004;24(42):9220-2.

3. Tracey WD Jr, “Genetics can be painless: molecular genetic analysis of nociception in Drosophila” Chapter 16 in TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. In press (2006) edited by Liedtke, Taylor and Francis Group, LLC, Boca Raton FL

Presentations:

1. Tracey WD, Pepling M, Horb M, Thomsen G, Kitner C, Gergen JP (1996) Developmental functions of an Aml 1 homologue in Xenopus  embryogenesis. Transcriptional Regulations by Runt Domain Proteins in Development and oncogenesis. Stony Brook, NY. (slide presentation).

 

2. Tracey WD, Gergen JP (1997).  Maternally provided Gal4 as a tool for the quantitative analysis of gene function in vivo.  38th annual Drosophila research conference. San Diego, CA (slide presentation).

 

3. Tracey WD, Pepling M, Horb M, Thomsen G, Gergen JP (1997) A Xenopus homologue of aml-1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood.  4th Annual Runt domain meeting, Dartmouth NH, (slide presentation).

 

4. Tracey WD, Ning Q, Gergen JP (1998) Use of maternal Gal4 in a genetic screen for dosage sensitive interactions with RUNT.  39th annual Drosophila research conference, Washington D.C.(poster presentation).

 

5. Tracey WD, Pepling M, Horb M, Thomsen G, Gergen JP (1998) A Xenopus homologue of aml-1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood.  Northeast Developmental Biology Society meeting. Woods Hole, MA (poster presentation).

 

6. Tracey WD, Gergen JP (1998) Xaml in the hemangioblast and its effects on vascular endothelial cell formation.  5th Annual Runt domain meeting, Airlie House, Washington D.C. (slide presentation)

 

7. Tracey WD, Gergen JP, (1998) Identification of the hemangioblast in Xenopus  embryos.  7th Annual Xenopus Conference, Chia Laguna, Italy (poster presentation).

 

8. Tracey WD, Benzer S (2001) A Drosophila model for pain.  42nd annual Drosophila research conference, Washington, D.C.(slide presentation)

 

9. Tracey WD, Benzer S (2001) A Drosophila model for pain. Drosophila neurobiology meeting, Cold Spring Harbor.(slide presentation)

 

10. Zhong L, Stearns NA, Hofhine AM, Tracey WD, (2005) Transmembrane Topology of the TRPA channel Painless. Gordon Research Conference on Mechanotransduction & Gravity Signaling in Biological Systems, Briddeford, ME

 

11. Zhong L, Tracey WD (2006) The Drosophila mutant oblivious is defective in nociception. 47th Annual Drosophila Conference, Houston, TX

 

12. Hwang RY, Zhong L, Xu Y, Johnson T, Zhang F, Deisseroth K, Tracey WD (2007) Nociceptive multidendritic neurons protect Drosophila larvae from parasitoid wasps. Gordon Research Conference “Mechanosensory Transduction”, Biddeford, ME selected for hot topic talk.

 

13. Hwang RY, Zhong L, Xu Y, Johnson T, Zhang F, Deisseroth K, Tracey WD (2007) Nociceptive multidendritic neurons protect Drosophila larvae from parasitoid wasps.” Drosophila Conference on Neurobiology.  Cold Spring Harbor NY.  Platform presentation.

 

14. Neuronal circuitry of nociception and pain in Drosophila.  Presentation Authors: Hwang R.H.,  Johnson T., Zhong L., Hofhine A., Tracey W.D.  Janelia Farm Conference.  "Insect Behavior: Small Brains, Big Functions.”

           

15. Hwang RY, Zhong L, Johnson T, Stearns N, Tracey WD. (2007) Drosophila melanogaster as a model for pain. American Society for Anesthesiologists, San Francisco, CA

 

16. Hwang RY, Johnson T, Zhong L, Xu Y, Zhang F, Deisseroth K, Tracey WD. (2007) Optogenetic activation of neurons and behavior in Drosophila melanogaster larvae. Society for Neuroscience Meeting, San Diego, CA

 

17. Hwang RY, Zhong L, Xu Y, Johnson T, Zhang F, Deisseroth K, Tracey WD (2007) Nociceptive multidendritic neurons protect Drosophila larvae from parasitoid wasps. Society for Neuroscience Meeting, San Diego, CA.

 

18. Caldwell J, Walcott K, Tracey, WD (2008) A genome wide search for ion channels that are functionally required for mechanosensation. Janelia Farm Conference. “Force-Gated Ion Channels: From Structure to Sensation.”

 

 

Invited Talks and Seminars:

October 2001  Drosophila as a model to study pain. Anesthesiology Research Unit, Washington University Medical School, St. Louis, MO.         Hosted by Dr. Zhoufeng Chen.

 

June 2002        painless a Drosophila mutant defective in nociception. Institut fur Genetik und Neurobiologie, Biozentrum, Universitat Wurzburg, Germany. Hosted by Dr. Martin Heisenberg and Dr. Troy Zars.

 

August 2002    painless a mutant defective in nociception. Exelixis, San Francisco. Hosted by Dr. Thomas Kidd.

 

April 2003      painless, a Drosophila gene essential for nociception.  Columbia University Biology Seminar. Hosted by Martin Chalfie.

 

July 2003         Genetics of mechanical and thermal nociception in Drosophila. Gordon Conference on Gravity Signalling and Mechanosensation. New London CT. Organizers: Mike Gustin, Martin Chalfie.

 

April 2005      Genetics can be painless: molecular genetic analysis of nociception in Drosophila. Dept. of Neurobiology, Neuroscience Seminar Series. University of North Carolina – Chapel Hill.

 

September 2005 Genetics can be painless: molecular genetic analysis of nociception in Drosophila Department of Cell Biology, University of Georgia at Athens

 

May 2006        Functional analysis of multidendritic neurons.  Department of Neurobiology. Neuroscience Seminar Series. University of North Carolina – Chapel Hill.

 

March 2007     Neuronal circuitry of nociception and pain in Drosophila.  Presentation Authors: Hwang R.H.,  Johnson T., Zhong L., Hofhine A., Tracey W.D.  Janelia Farm Conference.  "Insect Behavior: Small Brains, Big Functions"

 

October 2007  Nociceptive multidendritic neurons protect Drosophila larvae from parasitoid wasps. Cold Spring Harbor Laboratory “Neurobiology of Drosophila” Meeting

 

November 2007 Drosophila as a model for nociception research: a painless operation.  The Novartis Genome Research Institute. 

 

February 2008 Genetic analysis of nociception in Drosophila. A painless operation.  Yale University Physiology Seminar Series

 

Research Support :

	Duration	PI	% Effort	Purpose	Direct costs
Past W. M. Keck Discovery Award	3/2000-2004	Benzer			$166,000
Present Alfred P. Sloan Research Fellowship	09/16/05 – 09/15/07	Tracey	0%	Awarded for genetic analysis of nociception in Drosophila.	$67,500
Whitehall Foundation “Genetic analysis of nociception in Drosophila”	02/01/06 – 12/31/09	Tracey	20%	The goal is structure function analysis of painless and characterization of a new nociception gene called oblivious.	$225,000
NINDS / NIH “Genetic Analysis of Nociception in Drosophila”	04/01/07 – 03/31/12	Tracey	50%	The goal of this project is to understand nervous system function and molecular mechanisms of  nociception.	$1,093,750

 

 

 

 

US Patents:

Patent No. 7,018,617 entitled Methods and Compositions Associated with Nociceptive Pain.   2006.