Professor Perry F. BARTLETT, FAA (Fellow of the Australian Academy of Science)

Academic Qualifications

1970 BDSc, University of Melbourne

1975 PhD, University of Melbourne

Current Appointments

2002 Professor, Chair of Molecular Neuroscience

The University of Queensland

2003 ARC Federation Fellow

Director, Queensland Brain Institute, UQ

Previous Key Appointments

1994- 2002 NHMRC Principal Research Fellow/ Senior Principal Research Fellow

Head, Development and Neurobiology Group

Walter and Eliza Hall Institute

Honours and Awards

1991 The Inaugural John Woodward Prize for Excellence in Neuroscience, awarded by the

Australian Brain Foundation

2000 Australian Neuroscience Society Plenary Lectureship

The Bethlehem-Griffith Research Medal and Prize for Neuroscience

2003 Elected Fellow of the Australian Academy of Science

Current Major Grants

2003-08 ARC Federation Fellowship, PF Bartlett: $1,475,000

2004-08 NHMRC Program Grant, PF Bartlett, SS Tan, TJ Kilpatrick, P Sah: $6.474 million

2005-08 Spinal Cure Australia Lisa Palmer Spinal Research Consortium PF Bartlett, AW Boyd,

AM Turnley,MP Galea: $650,000

2006-11 ARC Thinking Systems Grant Wiles, Bartlett, Burrage, Goodhill, Mattingley, Sah, Smith,

Srinivasan, Wyeth, Arbib, Elman, O'Keefe; $3,300 million

2008-10 NHMRC Project Grant, PF Bartlett, AW Boyd, AM Turnley, D Nikolov: $598,250

2008-12 ARC Discovery Grant, GM Lu, PF Bartlett, ZP Xu, HM Cooper, PF Bartlett. $1.33 million

International Profile

Past President, Australian Neuroscience Society (2000-02)

Executive Member of the International Brain Organization (IBRO) and the Federation of Asian and Oceanic Neuroscience Societies (FAONS), involved in developing neuroscience education and research policy for the Asia-Pacific Region (2000-02)

Member of the Human Frontier Science Program Review Committee (2004-)

Frequent invitations to speak at the world’s foremost scientific forums (16 national and 28 international invited presentations in the past 5 years, including 5 plenary lectures)

Member of three international editorial boards

Member of National Neuroscience Consultative Taskforce (2004- )

Member of the Cellular Therapies Advisory Committee, formerly the Gene Technology Advisory Panel (2003- ).

Research Translation

Holder of 8 US patents related to research outcomes

Publications More than 170 peer-reviewed papers and reviews, many of which have appeared in the highest impact journals: 3 in Nature, 1 in each of Science, Nature Medicine, Nature Neuroscience and Neuron, 13 in PNAS, 11 in Journal of Neuroscience, 6 in Development and 4 in Journal of Biological Chemistry. Together these publications have attracted over 8000 citations. Ten papers have received >200 citations and another 12 have received >100 citations. 2001 Nature paper has already attracted 280 citations. Publications since 2003 are listed below:

1. Coonan JR, Bartlett PF, Galea MP (2003) Role of EphA4 in defining the position of a motoneuron pool within the spinal cord. Journal of Comparative Neurology 458: 98-111.

2. Gillespie LN, Clark GM, Bartlett PF, Marzella PL (2003) BDNF-induced survival of auditory neurons in vivo: cessation of treatment leads to accelerated loss of survival effects. Journal of Neuroscience Research 71: 785-790.

3. Murray SS, Bartlett PF, Lopes EC, Coulson EJ, Greferath U, Cheema SS (2003) Low-affinity neurotrophin receptor with targeted mutation of exon 3 is capable of mediating the death of axotomised axons. Clinical and Experimental Pharmacology and Physiology 30: 217-222.

4. Forger NG, Prevette D, deLapeyriere O, de Bovis B, Wang S, Bartlett P, Oppenheim RW (2003) Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. Journal of Neuroscience 23: 8854-8858.

5. Rietze RL, Bartlett PF (2003) Regulation of endogenous stem cells in the adult mammalian brain: promoting neural repair. In: Handbook of Cell Signaling Volume 3 (eds R Bradshaw and E Dennis) San Diego: Elsevier Science, pp. 625-634.

6. Ransome MI, Goldshmit Y, Bartlett PF, Waters MJ, Turnley AM (2004) Comparative analysis of CNS populations in knockout mice with altered growth hormone responsiveness. European Journal of Neuroscience 19: 2069-2079.

7. Goldshmit Y, Galea MP, Wise G, Bartlett PF, Turnley AM (2004) Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. Journal of Neuroscience 24: 10064-10073. Highlighted by the Faculty of 1000 as a “must read”; winner of the 2006 Australian Neuroscience Society Paxinos-Watson Prize for most significant publication by a member of the society in 2004.

8. Coulson EJ, Reid K, Shipham KM, Morley S, Kilpatrick TJ, Bartlett PF (2004) The role of neurotransmission and the Chopper domain in p75NTR death signaling. Progress in Brain Research: NGF and related molecules in health and disease 146: 41-62.

9. Bull ND, Bartlett PF (2005) The adult mouse hippocampal progenitor is neurogenic but not a stem cell. Journal of Neuroscience 25: 10815-10821.

10. Grote HE, ND Bull ND, Howard ML, van Dellon A, Blakemore C, Bartlett PF, Hannan AJ (2005) Cognitive disorders and neurogenesis deficits in Huntington’s disease mice are rescued by fluoxetine. European Journal of Neuroscience 22: 2081-2088.

11. Xu ZP, Stevenson GS, Lu C-Q, Lu GQ, Bartlett PF, Gray PP (2006) Stable suspension of layered double hydroxide nanoparticles in aqueous solution. Journal of the American Chemical Society 128: 36-37.

12. Young KM, Bartlett PF, Coulson EJ (2006) Neural progenitor number is regulated by nuclear factor-kB p65 and p50 subunit-dependent proliferation rather than cell survival. Journal of Neuroscience Research 83: 39-49.

13. Goldshmit Y, Galea MP, Bartlett PF, Turnley AM (2006) EphA4 regulates central nervous system vascular formation. Journal of Comparative Neurology 497: 864-875.

14. Merson TD, Rietze RL, Bartlett PF, Thomas T, Voss AK (2006) The transcriptional co-activator Querkopf controls adult neurogenesis. Journal of Neuroscience 26: 11359-11370.

15. Fawcett JW, Curt A, Steeves JD, Coleman WP, Tuszynski MH, Lammertse D, Bartlett PF, Blight AR, Dietz V, Ditunno J, Dobkin BH, Havton LA, Ellaway PH, Fehlings MG, Privat A, Grossman R, Guest JD, Kleitman N, Nakamura M, Gaviria M, Short D (2007) Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 45: 190-205.

16. Steeves JD, Lammertse D, Curt A, Fawcett JW, Tuszynski MH, Ditunno JF, Ellaway PH, Fehlings MG, Guest JD, Kleitman N, Bartlett PF, Blight AR, Dietz V, Dobkin BH, Grossman R, Short D, Nakamura M, Coleman WP, Gaviria M, Privat A (2007) Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures. Spinal Cord 45: 206-221.

17. Tuszynski MH, Steeves JD, Fawcett JW, Lammertse D, Kalichman M, Rask C, Curt A, Ditunno JF, Fehlings MG, Guest JD, Ellaway PH, Kleitman N, Bartlett PF, Blight AR, Dietz V, Dobkin BH, Grossman R, Privat (2007) Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics. Spinal Cord 45: 222-231.

18. Coultas L, Terzano S, Thomas T, Voss A, Reid K, Stanley EG, Scott CL, Bouillet P, Bartlett P, Ham J, Adams JM, Strasser A (2007) Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. Journal of Cell Science 120: 2044-2052.

19. Xu ZP, Kurniawan ND, Bartlett PF, Lu GQ (2007) Enhancement of relaxivity rates of GD-DTPA complexes by intercalation into layered double hydroxide nanoparticles. Chemistry 13: 2824

20. Xu ZP, Walker TL, Lin K, Cooper HM, Lu GQ, Bartlett PF (2007) Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA. International Journal of Nanomedicine 2: 163-174.

21. Young KM, Merson TD, Sotthibundhu A, Coulson EJ, Bartlett PF (2007) p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells. Journal of Neuroscience 27: 5146-5155. Recommended by the Faculty of 1000.

22. Morley SM, Power JM, Coulson EJ, Bartlett PF (2007) Zinc toxicity is dependent on Trk activation Experimental Neurology 205: 360-366.

23. Nandam LS, Jhaveri D, Bartlett P (2007) 5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression. Clinical and Experimental Pharmacology and Physiology 34: 546-551.

24. Stafford MR, Bartlett PF, Adams DJ (2007) Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone. Molecular and Cellular Neuroscience 35: 535-548.

25. Walker TL, Yasuda T, Adams DJ, Bartlett PF (2007) The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells. Journal of Neuroscience 27: 3734-3742.

26. Yasuda T, Bartlett PF, Adams DJ Kir and Kv channels regulate electrical properties and proliferation of adult neural precursor cells. Mol Cell Neuroscience 37: 284-297, 2008

27. Underwood CK, Reid K, May LM, Bartlett PF, Coulson EJ. Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by g-secretase. Mol Cell Neuroscience 37: 346-358, 2008

28. Coulson EJ, May LM, Osborne S, Reid K, Underwood CK, Meunier FA, Bartlett PF, Sah P (2008) p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate. Journal of Neuroscience 27: 3734-3742.

29. Walker TL,White A, Black DM, Wallace RH, Sah P, Bartlett PF (2008) Latent stem and progenitor cells in the hippocampus are activated by neural excitation. Journal of Neuroscience 28: 5240-5247. (front cover) .

31岁颜宁受聘清华大学	丹扬（dan yang）教授	著名美籍华人分子生物	“聪明鼠”之父钱卓
著名神经生理学家张香	变性教授挑战性别歧视	Mu-ming Poo: Neurobi	Binhai Zheng--神经生

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Professor Perry F. BARTLETT

Honours and Awards

1991 The Inaugural John Woodward Prize for Excellence in Neuroscience, awarded by the

Current Major Grants

International Profile

Research Translation

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