NAME:                Guang-Yin Xu, M.D., Ph. D.

PRESENT POSTION AND ADDRESS:

Assistant Professor Department of Internal Medicine University of Texas Medical Branch Galveston, TX 77555-0632     Email: gyxu@utmb.edu

 

                                                       

EDUCATION AND DEGREES:

 

9/1995-7/1998       Shanghai Brain Research Institute Shanghai Center for Life Science Chinese Academy of Sciences, Shanghai, China Ph. D. in Neurobiology

 

9/1989-7/1992       Department of Physiology and Neurobiology Suchou University Medical College, Suzhou, P.R. China M. S. in Physiology

 

9/1981-7/1986       Nantong University Medical College, Nantong, P.R. China                                     M. D. in Medicine

 

Journal Reviewer And Reviewing Work:

 

Brain Research Acta Phyisologica Sinica (The Chinese Journal of Physiology)

 

Research Grant Awards:

 

1. Plasticity of P2X receptor in chronic visceral hyperalgesia. National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator (30% effort): Guang-Yin Xu; Co-investigator: Pankaj Jay Pasricha; Funding: Pending.

2. Mechanisms of sensitization in a rat model of chronic visceral hypersensitivity. National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator: Dr. John Winston; Co-investigator (20% effort): Guang-Yin Xu; Funding: Pending.
3. Molecular Mechanisms of Pain in Chronic Pancreatitis”.  National Institute of Diabetes & Digestive & Kidney Diseases R01. $1,819,550.00/4yrs. Principal Investigator: Pankaj Jay Pasricha; Co-investigator (50% effort): Guang-Yin Xu; Funding: funded.  This proposal examines the hypothesis that the pathogenesis of pain in chronic pancreatitis involves changes in pancreas-specific sensory neuronal excitability and neurotransmitter expression/release and that such changes are mediated, at least in part, by nerve growth factor (NGF) expressed in pancreatic tissue. The goals of this project are to determine the ionic and molecular basis for increased excitability of pancreas-specific primary nociceptive neurons in chronic pancreatitis, to determine the effects of chronic pancreatitis on expression and release of peptide neurotransmitters and their role in maintaining nociceptive sensitization and to determine the role of NGF in the pathogenesis of pain behavior and pancreas-specific sensory neuronal responses in chronic pancreatitis.  Guang-Yin will perform pancreas-specific sensory neuron excitability and ion channel activity experiments.
4. 1996-1998, Co-Principal Investigator in research project entitled “The role of IL-2 in Pain Modulation”, Research foundation of National Nature Science Foundation of China.

5. 1993-1995, Director and Principal Investigator in research project entitled “The Critical Role of SN in Electroacupuncter Analgesia in Adjuvant Arthritic Rats”, Research foundation of Nantong University Medical School.

MEMBERSHIP IN SCIENTIFIC SOCIETIES:

 

1999-               Society for Neuroscience

2005-               American Gastroenterological Association

1995-1998       Chinese Association for Pain Study

 

HONORS:

           

1. The first prize awarded by Education Department in China, 2004
2. The Award Winner for the oral presentation at the 7th annual UTMB-CSA life science symposium.  Galveston, Texas, 2003.
3. The traveling Award from the International Congress of Phsyiological Science, 1997
4. The first prize awarded by president of Chinese Academy of Sciences, 1997.
5. The third prize awarded by the Chinese Society for Neuroscience, 1997.
6. The third prize awarded by the Association of Science and Technology of Nantong, Jiangsu province, P. R. China,  1995.

7. The third prize awarded by Chairman of Academic Committee of Nantong Medical College, 1993.

8. The fourth prize awarded by Chairman of Academic Committee of Nantong Medical College. 1993.
9. The third prize awarded by the Department of Basic Medicine of Nantong Medical College, 1993.
10. The first prize awarded by the president of Suzhou Medical College, 1993.

 

 

Professional Conferences:

 

1. The 35th Annual Meeting of the Society for Neuroscience, Atlanta, GA, Oct. 14-18, 2006
2. Neurogastroenterology and Motility 2006 first Joint International Meeting in Boston, MA, September 13-16, 2006
3. The 4th International Neuroscience Symposium in China, Kunming, P.R. China, July 1-8, 2006
4. Digestive Disease Week and the 107th Annual Meeting of American Gastroenterological Association, Los Angelus, CA, May 13-18, 2006
5. The 34th Annual Meeting of the Society for Neuroscience, Washington DC, Nov. 12-16, 2005
6. Gulf Coast GI Research Forum, June 4, 2005, League City, Texas.
7. The 106th Annual Meeting of the American Gastroenterological Association, May 14-18, 2005, Chicago, IL
8. The 7th annual UTMB-CSA Life Science Symposium.  Galveston, Texas, May 23, 2003.
9. The thirty-one Annual Meeting of Society for Neuroscience, Orlando, USA, Nov., 2002.

10. The thirty-one Annual Meeting of Society for Neuroscience, San Diego, USA, Nov., 2001.

11. Neuroscience Graduate Program Poster Session for BBSC Orientation (BBSC 6105), Levin Hall, UTMB, Oct. 16, 2001.
12. The 5th Annual Life Science Symposium. Levin Hall, UTMB, May, 2001.
13. The 30th Annual Meeting of Society for Neuroscience, New Orleans, USA, Oct., 2000.
14. Forum on Neuroscience, the University of Texas Medical Branch. William C. Levin Hall, Feb., 2000
15. The 3rd Annual Life Science Symposium. Levin Hall, UTMB, Nov, 1999.
16. The twenty-ninth Annual Meeting of Society for Neuroscience, Miami, USA, Oct., 1999.
17. The XXXIII International Congress of Physiological Sciences, P084.47, St. Petersburg, Russian, July, 1997.
18. The second Biennial Meeting of Chinese Society for Neuroscience.  Xi’an, P. R.  China, Oct., 1997.
19. The first Biennial Meeting of Chinese Society for Neuroscience.  Shanghai, P. R. China, Oct., 1995.
20. The twenty-seventh National Meeting of Chinese Society for Physiological Science, Wuhan, P. R.  China, May, 1994.
21. The second Congress of Pacific and Asia organization of Physiological science (PAOPS). Shanghai, P. R. China, 1994.
22. The third National Meeting of Endocrinology, Suzhou, P. R. China, Nov., 1992.
23. The second East-West Pain Congress, Beijing, P. R. China, Oct., 1992.

 

ARTICLES IN PEER-REVIEWED JOURNALS:

 

1. Xu G-Y, Winston J H, Shenoy M, Yin H and Pasricha P J. TRPV1 Expression and Function in Chronic Pancreatitis and its Role in Nociceptive Sensitization and Pain.  Gastroenterology, 133(4):1282-1292, 2007

2. Xu G-Y, Winston J H, Shenoy M,.Yin H. and Pasricha PJ. Enhanced excitability and suppression of A-type potassium current of pancreas specific afferent neurons in a rat model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol, 291:424-431, 2006.

3. Xu G-Y and Huang L-Y M. Calcium/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors. Proc. Natl. Acad. Sci. U. S. A. 101(32):11868-11873, 2004.
4. Xu Y, Gu Y-P, Xu G-Y, Li G-W, Wu P and Huang L-Y M. Adeno-associated viral transfer of opioid receptor gene to primary sensory neurons: A strategy to increase opioid antinociception. Proc. Natl. Acad. Sci. U. S. A. 100: 6204-6209, 2003.
5. Xu G-Y and Zhao Z-Q. Cross-inhibition of mechanoreceptive inputs in peripheral inflammatory cat.  Brain Research, 970 (1-2):188-194, 2003.
6. Xu G-Y and Huang L-Y M.  Peripheral inflammation sensitizes P2X-receptor mediated responses in rat dorsal root ganglion neurons. Journal of Neuroscience, 22(1):93-102, 2002.

7. Xu G-Y and Zhao Z-Q.  Changes in excitability and phenotype of substance P and its receptor in cat Ab sensory neurons following peripheral inflammation.  Brain Research, 923(1-2): 112-119, 2001.

8. Xu G-Y, Huang L-Y M and Zhao Z-Q.  Activation of silent mechanoreceptive cat C and A-delta sensory neurons and their SP expression following peripheral inflammation.  Journal of Physiology (Lond.), 528:339-348, 2000.
9. Deng C-Z., Xu G-Y, Xu H-J., Lu G-M., Jin G-H., Gu Z-K and Luo D-D. Observations on brain electrical activity mapping in patients with cerebrocranium injury and fetal transplatation.  Journal of Anatomy and Clinical Practice, 4(3):131-134, 1999.
10. Xu G-Y, Liu L-G and Zhao Z-Q.  Characteristics of spontaneous discharges of Ab neurons in dorsal root ganglion in inflammatory pain of cat.  Chinese Journal of Neuroscience, 14(4):193 198, 1998.
11. Zhang Q-Q, Xu G-Y, Sha B-X and Ma H-P.  Therapy of Han's-TENS on adjuvant-induced arthritis in rat.  Chinese Journal of Pain Medicine.  3(1):45-48, 1997.
12. Lu G-M, Wu Y-M, Xu H-J, Ling S-C, Xu G-Y and Zheng Z-L.   EEG power spectral analysis and morphological study in front cortex lesioned rats.  Chinese Journal of Neuroanatomy, 12(1):42-46, 1996.
13. Xu G-Y, Zhang Q-Q, Duanmu Z-X, and Yin Q-Z.  Influence of electroacupuncture on nociceptive responses of neurons in parafascicular nuclei and PAG in arthritic rats.   Acta Medicinae Nantong, 15(3):72-75, 1995.
14. Xu G-Y and Chen Q-L.  Analysis of College marks of Students in Physiological group.  Journal of Nantong Education Research, 12:38-40, 1995.
15. Xu G-Y, Duanmu Z-X and Yin Q-Z.  Reversal of the inhibitory effect of electroacupuncture on the nociceptive response of neurons in parafascicular nucleus in acute arthritic rats.  Acta Physiological Sinica (The Chinese Journal of Physiology), 46(5):427-434, 1994 [Chemical Abstr. 122(9):85, 1995]
16. Lu G-M, Xu H-J, Wu Y-M , Xu G-Y and Deng CZ.  Brain electrical activity mapping and morphology study of cerebro-transplantation.  Chinese Journal of Anatomy, 17-184, 1994.
17. Xu G-Y, Duanmu Z-X and Yin Q-Z. CGRP and pain modulation.  Progress in Physiological Sciences, 24(1):67-69, 1993 [Medline Express(R) 1/93-12/93]
18. Xu G-Y, Duanmu Z-X and Yin Q-Z.  The role of ACH on pain modulation and analgesia in central nerve system. Acupuncture Reserch, 18(1):1-7, 1993.
19. Xu G-Y, Chen Q-L, Fu Z-Z, Xu X-B and Chen L.  Study on the method of observation of pacemaking of toad heart.  Acta Academiae Suzhou, 13 (Suppl.),429-432, 1993
20. Xu G-Y, Duanmu Z-X and Yin Q-Z.  Influence of naloxone and atropine on the enhancement of pain threshold of electroacupuncture in arthritic rats.  Acta Medicinae Nantong, 12(4):289 292, 1992.

 

Submitted/In preparation:

1. Guang-Yin Xu, John H Winston, Mohan Shenoy, Yin Huaizhi and Pankaj J Pasricha. Peripheral Sensitization and the Role of P2X Receptors in the Pathogenesis of Visceral Hypersensitivity in a Rat Model of Irritable Bowel Syndrome.  (under revision, Corresponding author)

2. Guang-Yin Xu, Li G, Gu Y, Wang C and Huang L-Y M. Increase of membrane P2X receptors expression contributes to the streptozotocin-induced allodynia in rats. (In preparation)
3. Guang-Yin Xu and Pankaj J Pasricha. Electrophysiological and phenotypic distinction of thoracolumbar and lumbosacral dorsal root ganglion neuron innervating the colon in normal and neonatal acetic acid treated rat. (In preparation)

 

ABSTRACTS:

 

1. Xu G-Y, Shenoy M, Winston JH and Pasricha PJ.  Distinct Mechanisms of Sensitization of Thoracolumbar and Lumbosacral Colonic Sensory Neurons in a Rat Model of IBS-like Chronic Visceral Hyperalgesia.  DDW meeting Washington DC, 2007
2. Xu G-Y, Shenoy M, Winston JH and Pasricha PJ. Mechanisms underlying the enhanced TRPV1-mediated responses of pancreas-specific sensory neurons in a rat model of chronic pancreatitis.  35th Annual Meeting of Society for Neuroscience, Atlanta, Georgi,a 2006 (Invited oral presentation for SFN 2006)

3. Xu G-Y, Shenoy M, Winston JH and Pasricha PJ. Sensitization of P2X receptors contributes to the visceral hyperalgesia in a rat model of irritable bowel syndrome.  AMS meeting, Boston, 2006
4. Xu Guang-Yin, Winston John H, Shenoy Mohan, Yin Huaizhi, and Pasricha Pankaj Jay. TRPV1 Expression and Function in Chronic Pancreatitis and its Role in Nociceptive Sensitization and Pain.  Gastroenterology, 130(4):A74. (Invited oral presentation for DDW 2006)
5. Xu Guang-Yin, Shenoy Mohan, Winston John H, Yin Huaizhi and Pasricha Pankaj Jay. Peripheral Sensitization and the Role of P2X Receptors in the Pathogenesis of Visceral Hypersensitivity in a Rat Model of Irritable Bowel Syndrome. Gastroenterology, 130(4):A252, 2006.
6. Xu Guang-Yin, Winston John H, Shenoy Mohan, Yin Huaizhi and Pasricha Pankaj Jay.  Nociceptor Excitability Is Associated with Suppression of A-Type Potassium Currents: Insights into the Pathogenesis of Pain in Chronic Pancreatitis. Gastroenterology, 130(4):A251, 2006.
7. Xu Guang-Yin, Yin Huaizhi, Winston John H and Pasricha Pankaj Jay.  Suppression of Transient A-type Potassium Currents and Enhanced Excitability of Dorsal Root Ganglion Neurons in A Model of Painful Chronic Pancreatitis.  34nd Annual Meeting of Society for Neuroscience, Washington DC, 2005

8. Xu Guang-Yin, Huaizhi Yin, John Winston, Mohan Shenoy and Pankaj Jay Pasricha.  Chronic pancreatitis results in increased excitability and TRPV1 responsiveness of primary nociceptive neurons in chronic pancreatitis.  14th Meeting of the American Motility Society, Santa Monica, CA, 2005

9. Xu G-Y and Huang L-Y M. Calmodulin Protein Kinase IIa Modulation Contributes to the enhancement of ATP Responses in Dorsal Root Ganglion Neurons after Inflammation. 33nd Annual Meeting of Society for Neuroscience, San Diego, Nov., 2004.
10. Xu G-Y and Huang L-Y M. Calmodulin Protein Kinase IIa Modulation Contributes to the enhancement of ATP Responses in Dorsal Root Ganglion Neurons after Inflammation. 33nd Annual Meeting of Society for Neuroscience, New Orleans, Nov., 9, 2003.
11. Xu G-Y, Xu Y, Li GW and Huang L-YM. Opioid inhibition of voltage-dependent Ca channels is potentiated in rat dorsal root ganglion neuron Transduced with Mu-Opioid receptors using Adeno-associated viral vector. 32nd Annual Meeting of Society for Neuroscience, Orlando, Nov., 11, 2002.
12. Xu G-Y and Huang L-Y M. Upregulation of P2X receptor expression contributes to the potentiation of ATP-induced responses in rat dorsal root ganglion neurons. 31th Annual Meeting of Society for Neuroscience, San Diego, Nov., 27, 2001.
13. Xu G-Y and Huang L-Y M. Calmodulin protein kinase II modulates the P2X receptor mediated responses in dorsal root ganglion neurons. 30th Annual Meeting of Society for Neuroscience, New Orleans, Nov., 26:99, 2000.
14. Xu G-Y and Huang L-Y M. Peripheral inflammation potentiates P2X-receptor mediated responses in rat dorsal root ganglion neurons.  29th Annual Meeting of Society for Neuroscience, Miami, P459, 181.2, Oct., 1999.
15. Xu G-Y and Zhao Z-Q.  Changes of physiological properties and Substance P-like immunoreactivity of neurons of lumbar dorsal root ganglia in inflamed cats.  Abstract of XXXIII International Congress of Physiological Sciences, P084.47, St.  Petersburg, 1997.
16. Xu G-Y, Lei L-G, Tao Y-X and Zhao Z-Q. Changes of membrane properties and Substance P content in physiologically identified nociceptive primary neurons in inflammatory cats.  CAPS New communication, P37, 16 (Suppl. 2), 1997.
17. Xu G-Y.  Substance P immunoreactivity in the physiologically identified sensory neurons activated by injection of carrageenan.  The second Biennial Meeting of Chinese Society for Neuroscience.  Chinese Journal of Anatomy, 13(suppl):357, Xi’an, 1997.
18. Xu H-J, Wu Y-M, Lu G-M and Xu G-Y.  Transplantation of fetal neocortical tissue in damaged frontal cortex of young adult rats. The fourth IBRO word congress of Neuroscience, C4.24, Kyoto (in English), 1995.
19. Deng C-Z, Xu G-Y, and Xu H-J.  Study of brain electrical activity mapping in patients with craniocerebral injury and brain transplantation. The first Biennial Meeting of Chinese Society for Neuroscience. P252-253, P-76, Shanghai, 1995.
20. Lu G-M, Xu H-J, Wu YM, Xu G-Y. and Deng CZ.  Study of Brain electrical activity mapping of experimental brain transplantation and observation of morphology. The first Biennial Meeting of Chinese Society for Neuroscience.  P252, P-75, Shanghai, 1995.
21. Xu G-Y, Duanmu Z-X and Yin Q-Z.  Reversal of the inhibition of electroacupuncture (EA) on the nociceptive response of neurons in parafascicular nucleus (PF) by naloxone and atropine in arthritic rats.  Abstract of the Second East-West Pain Conference, PP59, Beijin, Oct., 1992.

 

Supervisory Work:

 

1. Member of Graduate Student Supervisor Committee: LU Guang-Ming, Master of Science, received from Nantong Medical College in June, 1996. (Supervisory Professors, Hui-Jun Xu and Yi-Min Wu).  Dissertation Topic: Experimental Study on The Function And Morphology of Transplantation of Fetal Neocortical Tissue in Damaged Frontal Cortex in Rats.

2. Coordinator of Advanced Physiological Research Program for Undergraduate Students:  FU Zheng-Zheng, XU Xiao-Le, CHEN Qi, et al. (14 undergraduate students) from September, 1990 to August, 1991.  Research Topic: Study on the Method of Observation of Pace making of Toad Heart (Ref. Acta Academiae Suzhou, 13 (Suppl.),429-432, 1993)

 

Social and Volunteer Work:

 

1. 08/2000-07/2001, Co-Chairman of Chinese Student Association at UTMB.

2. 08/1996-07/1998, Chairman of Graduate Student Association of Shanghai Brain Research Institute, Chinese Academy of Sciences.
3. 08/1997-07/1998, Chairman of Union of the chairmen of Graduate Student Association of Shanghai Branch, Chinese Academy of Science

4. 09/1989-07/1992, Vice Chairman of the Graduate Students Association of Suzhou Medical College, P. R.  China.

5. Volunteering to be a judge for the Medical Student Summer Research Program (MSSRP) poster session, UTMB, June 23, 2005