Jian Yang (杨建)

 

Department of Biological Sciences

917 Fairchild, MC2462

Columbia University, New York, NY 10027

  Email: jy160@columbia.edu

http://www.columbia.edu/cu/biology/faculty-data/jian-yang/faculty.html

 

 

 

Education:                  9/1978 - 7/1982          B.S.                                                                 Department of Biology, Beijing University, Beijing, China

 

9/1982 - 11/1985        M.S.                                                                Shanghai Brain Research Institute, Academia Sinica, Shanghai, China

 

9/1987 - 6/1991          Ph.D.                                                               Department of Physiology and Biophysics, University of Washington                                     Advisor: Dr. Bertil Hille

 

Postgraduate Training:

12/1985 - 8/1987        Visiting Scholar                                             Department of Anatomy and Neurobiology, Colorado State University                                     Advisor: Dr. Stephen D. Roper

 

8/1991-12/1993          Postdoctoral Fellow                                                   Department of Molecular and Cellular Physiology, Stanford University                                     Advisor: Dr. Richard W. Tsien

 

1/1994-12/1996          Postdoctoral Fellow                                       HHMI, Departments of Physiology and Biochemistry, UCSF                                     Advisor: Dr. Lily Y. Jan

 

Professional Positions:                      1/1997 – 4/2002          Assistant Professor                                         Department of Biological Sciences, Columbia University

 

4/2002 - 5/2004          Associate Professor                                        Department of Biological Sciences, Columbia University

 

6/2004 - present          Associate Professor (tenured)                                                Department of Biological Sciences, Columbia University

 

Awards

 

1.     Postdoctoral Fellowship, Muscular Dystrophy Association, 1/92 - 12/92. 2.     Harry Zimmerman Neuromuscular Disease Research Fellowship, Muscular Dystrophy Association, 1/93 - 12/94. 3.     Neuroscience Postdoctoral Training Grant, Neuroscience Program, UCSF, 1/96 – 12/96. 4.     Sloan Research Fellow, Alfred P. Sloan Foundation,  9/97 – 8/99. 5.     McKnight Scholar Award, The McKnight Endowment Fund for Neuroscience,  7/00 – 6/03 6.     EJLB Scholar, The EJLB Foundation, 12/01 – 11/04. 7.     Established Investigator Award, The American Heart Association, 1/04 - 12/08

 

 

Professional Service

                       

                        Editorial Board

                                    Biophysical Journal,  7/2004 -

 

                        Study Section

10/2003           Ad hoc member, NTRC study section, NIH                                     2/2004             Ad hoc member, NTRC study section, NIH                                     7/04-6/08       Regular member, NTRC study section, NIH

 

Bibliography :

 

1. Chen, Y-h*., He., L-l*., Buchanan, D.R., Zhang, Y.,  Fitzmaurice, A., and Yang, J. (2008).  Functional dissection of the intramolecular Src homology 3-guanylate kinase domain coupling in voltage-gated Ca2+ channels b-subunits.  Proc. Natl. Acad. Sci.  Under review.
2. Zhang, Y., Chen, Y-h., Bangaru, S.D., Abele, K., Tanabe, S., Kozasa, T., and Yang, J. (2008).  Origin of the voltage-dependence of G protein regulation of P/Q-type Ca2+ channels.  J. Neurosci.  Accepted.
3. Michailidis, Y., Zhang, Y., and Yang, J. (2007).  The lipid connection - Regulation of voltage-gated Ca2+ channels by phosphoinositides.  Pflugers Ach. 455, 147-155.  (Review)
4. He., L-l., Zhang, Y.,  Chen, Y-h., Fitzmaurice, A., and Yang, J. (2007).  Functional modularity of the b subunit of voltage-gated Ca2+ channels. Biophysical Journal 93, 834-845.
5. Zhen, X-G*., Xie, C*., Yamada, Y., Zhang, Y., Doyle, C., and Yang, J. (2006).  A single amino acid mutation slows rundown of voltage-gated calcium channels.  FEBS Letters  580, 5733-5738.
6. Zhen, X-G*., Xie, C*., Orenstein, E., and Yang, J.  (2005).  Functional architecture of the inner pore of a voltage-gated Ca2+ channel.  J. Gen. Physiol. 126, 193-204.

7. Xie, C*., Zhen, X-G*., and Yang, J. (2005).  Localization of the activation gate of a voltage-gated Ca2+ channel.  J. Gen. Physiol.  126, 205-212.

8. Gamper, N., Reznikov, V., Yamada, Y., Yang, J., and Shapiro, M.S. (2004).  PIP2 signals underlie receptor-specific Gq/11-mediated modulation of N-type Ca2+ channels.  J. Neurosci.  24, 10980-10992.

9. Chen, Y-h., Li, M-h., Zhang, Y.,  He., L-l., Yamada, Y., Fitzmaurice, A., Shen, Y., Zhang, H., Tong, L., and Yang, J. (2004).  Structural basis of the a1-b interaction of voltage-gated Ca2+ channels.  Nature 429, 675-680.
10. Jun, X., Zhen, X-G., and Yang, J. (2003).  Localization of PIP2 activation gate in inward rectifier K+ channels.  Nature Neurosci. 6, 811-818.
11. Wu, L., Bauer, C., Zhen, X-G., Xie, C., and Yang, J. (2002).  Dual regulation of voltage-gated calcium channels by PIP2.  Nature 419, 947-952.
12. Lopes, C.M.B., Zhang, H., Rohacs, T., Jin, T.,  Yang, J., and Logothetis, D.E. (2002).  Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies.  Neuron 34, 933-944.
13. Lu, T., Wu, L., Xiao, J., and Yang, J. (2001).  Permeant ion-dependent changes in gating of Kir2.1 inward rectifier potassium channels.  J. Gen. Physiol. 118, 509-521.
14. Lu, T., Ting, A.Y., Mainland, J., Jan, L.Y., Schultz, P.G., and Yang, J. (2001).  Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.  Nature Neurosci. 4, 239-246.
15. Lu, T., Zhu, Y-G., and Yang, J. (1999).  Cytoplasmic amino and carboxyl domains form a wide internal vestibule in an inwardly rectifying K+ channel.  Proc. Natl. Acad. Sci. 96, 9926-9931.
16. Lu, T., Zhang, X-M., Nguyen, B., and Yang, J. (1999).  Architecture of a K+ channel inner pore revealed by stoichiometric covalent modification.  Neuron 22, 571-580.
17. Yang, J., Jan, Y.N., and Jan, L.Y. (1997).  Stabilization of ion selectivity filter by pore loop ion-pairs in an inward rectifier K+ channel.  Proc. Natl. Acad. Sci. 94, 1568-1572.
18. Fakler, B., Schultz, J., Yang, J., Schulte, U., Brandel, U., Zenner, H.P., Jan, L.Y., and Ruppersberg, J.P. (1996).  Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.  EMBO J. 15, 4093-4099.
19. Yang, J., Jan, Y.N., and Jan, L.Y. (1995a).  Determination of the subunit stoichiometry of an inwardly rectifying K+ channel.  Neuron 15, 1441-1447.
20. Yang, J., Jan, Y.N., and Jan, L.Y. (1995b).  Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.  Neuron 14, 1047-1054.
21. Ellinor, P. T., Yang, J., Sather, W.A., Zhang, J.F., and Tsien, R.W. (1995).  Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions.  Neuron 15, 1121-1132.
22. Sather, W. A., Yang, J., and Tsien, R.W. (1994).  Structural basis of ion channel permeation and selectivity.  Curr. Opinion in Neurobiol. 4, 313-323.  (Review)
23. Yang, J., Ellinor, P.T., Sather, W.A., Zhang, J.F., and Tsien, R.W. (1993).  Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels.  Nature 386, 158-161.
24. Yang, J., and Tsien, R.W. (1993). Enhancement of N- and L-type calcium channel currents by protein kinase C in frog sympathetic neurons.  Neuron 10, 127-136.
25. Yang, J., Mathie, A., and Hille, B. (1992). 5-HT3 receptor channels in dissociated rat superior cervical ganglion neurons.  J. Physiol. 448, 237-256.
26. Yang, J. (1990).  Ion permeation through 5-HT-gated channels in neuroblastoma N18 cells. J. Gen. Physiol. 96, 1177-1198.
27. Yang, J., and Roper, S.D. (1987).  Dye-coupling in taste buds in the mudpuppy, Necturus maculosus.  J. Neurosci. 7, 3561-3565.