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| Neuropsychopharmacology: The Fifth Generation of Progress
Edited by Kenneth L. Davis, Dennis Charney, Joseph T. Coyle, and Charles Nemeroff
© 2002 American College of Neuropsychopharmacology |
| All chapters are available for free viewing below. If you have purchased the hardcover book and have received your password, click here to access the downloadable, printable version online. |
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| SECTION 1: NEUROTRANSMITTER AND SIGNAL TRANSDUCTION |
- Neurotransmitter And Signal Transduction
- Eric J. Nestler And Ronald S. Duman
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| Chapter 1: PDF file |
- Acetylcholine
- Marina R. Picciotto, Meenakshi Alreja And J. David Jentsch
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| Chapter 2: PDF file |
- Serotonin
- George K. Aghajanian And Elaine Sanders-Bush
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| Chapter 3: PDF file |
- Opioid Peptides And Their Receptors: Overview And Function In Pain Modulation
- George K. Aghajanian And Elaine Sanders-Bush
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| Chapter 4: PDF file |
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| Chapter 5: PDF file |
- Regulation Of G Protein-Coupled Receptors By Phosphorylation And Endocytosis
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| Chapter 6: PDF file |
- The Diverse Roles Of L-Glutamic Acid In Brain Signal Transduction
- Joseph T. Coyle, Michael L. Leski And John H. Morrison
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| Chapter 7: PDF file |
- Corticotropin-Releasing Factor: Physiology, Pharmacology, And Role In Central Nervous System Disorders
- Errol B. De Souza And Dimitri E. Grigoriadis
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| Chapter 8: PDF file |
- Neurogenesis In Adult Brain
- Fred H. Gage And Henriette Van Praag
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| Chapter 9: PDF file |
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| Chapter 10: PDF file |
- Astrocytes
- Pierre J. Magistretti And Bruce R. Ransom
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| Chapter 11: PDF file |
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| Chapter 12: PDF file |
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| Chapter 13: PDF file |
- Substance P And Related Tachykinins
- Nadia M.J. Rupniak Mark S. Kramer
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| Chapter 14: PDF file |
- Histamine
- Jean-Charles Schwartz And Jean-Michel Arrang
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| Chapter 15: PDF file |
- Purinergic Neurotransmission
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| Chapter 16: PDF file |
- Neurotrophic Factors And Intracellular Signal Transduction Pathways
- David S. Russell And Ronald S. Duman
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| Chapter 17: PDF file |
- Regulation Of Gene Expression
- Eric J. Nestler And Steven E. Hyman
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| SECTION 2: EMERGING METHODS IN MOLECULAR BIOLOGY AND GENETICS |
- Emerging Methods In Molecular Biology And Genetics
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| Chapter 18: PDF file |
- Using Human Genomics To Advance Neuropsychopharmacology
- L. Alison Mcinnes And Nelson B. Freimer
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| Chapter 19: PDF file |
- Gene Targeting And Transgenic Technologies
- Laurence H. Tecott And David S. Johnson
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| Chapter 20: PDF file |
- Gene Delivery Into The Brain Using Viral Vectors
- Rachael L. Neve And William A. Carlezon, Jr
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| Chapter 21: PDF file |
- Neuropsychopharmacology Of Worms And Flies
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| Chapter 22: PDF file |
- Beyond Binding: Molecular And Cell Biological Approaches To Studying G-Protein Coupled Receptors
- Gabriel A. Vargas And Mark Von Zastrow
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| Chapter 23: PDF file |
- Applying Functional Genomics To Neuropsychopharmacology
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| SECTION 3: EMERGING IMAGING TECHNOLOGIES AND THEIR APPLICATION TO PSYCHIATRIC RESEARCH |
- Emerging Imaging Technologies And Their Application To Psychiatric Research
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| Chapter 24: PDF file |
- Automated 3D Analysis Of Large Brain MRI Databases
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| Chapter 25: PDF file |
- In Vivo Magnetic Resonance Spectroscopy Studies Of The Glutamate And GABA Neurotransmitter Cycles And Functional Neuroenergetics
- Douglas L. Rothman, Fahmeed Hyder, Nicola Sibson, Kevin L. Behar, Graeme F. Mason, Jun Shen, Ognen A. C. Petroff And Robert G. Shulman
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| Chapter 26: PDF file |
- The Spatial, Temporal, And Interpretive Limits Of Functional MRI
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| Chapter 27: PDF file |
- Diffusion Tensor Imaging
- Nikos Makris, G. M. Papadimitriou, A. J. Worth, Bruce G. Jenkins, L. Garrido, A. Gregory Sorensen, V. J. Wedeen, David S. Tuch, O. Wu, Merit E. Cudkowicz, V. S. Caviness Jr., B. R. Rosen And David N. Kennedy
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| Chapter 28: PDF file |
- Activation Paradigms In Affective And Cognitive Neuroscience: Probing The Neuronal Circuitry Underlying Mood And Anxiety Disorders
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| Chapter 29: PDF file |
- Interactions Among Neuronal Systems Assessed With Functional Neuroimaging
- Christian Büchel And Karl Friston
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| Chapter 30: PDF file |
- Measuring Brain Connectivity With Functional Imaging And Transcranial Magnetic Stimulation (TMS)
- Mark S. George And Daryl E. Bohning
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| Chapter 31: PDF file |
- In Vivo Molecular Imaging: Ligand Development And Research Applications
- Masahiro Fujita And Robert B. Innis
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| Chapter 32: PDF file |
- Event-Related Potentials And Magnetic Fields In The Human Brain
- Steven A. Hillyard And Marta Kutas
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| SECTION 4: DRUG DISCOVERY AND EVALUATION |
- Drug Discovery And Evaluation
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| Chapter 33: PDF file |
- The Role Of Preclinical Models In The Development Of Psychotropic Drugs
- Mark A. Geyer And Athina Markou
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| Chapter 34: PDF file |
- Proof Of Concept: Functional Models For Drug Development In Humans
- Dean F. Wong, William Z. Potter And James R. Brasic
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| Chapter 35: PDF file |
- Ethical Aspects Of Neuropsychiatric Research With Human Subjects
- Debra A. Pinals And Paul S. Appelbaum
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| Chapter 36: PDF file |
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| Chapter 37: PDF file |
- Pharmacogenomics And Personalized Therapeutics In Psychiatry
- Vural Özdemir, Vincenzo S. Basile, Mario Masellis, Pierandrea Muglia And James L. Kennedy
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| Chapter 38: PDF file |
- Pharmacokinetics, Pharmacodynamics, And Drug Disposition
- David J. Greenblatt, Lisa L. Von Moltke, Jerold S. Harmatz And Richard I. Shader
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| Chapter 39: PDF file |
- The Role Of Pharmaceuticals In Mental Health Care Outcomes
- Ramin Mahmoud, Chris M. Kozma, C. E. Reeder, Amy Grogg And Brian Meissner
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| Chapter 40: PDF file |
- Issues In Clinical Trial Designs
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| SECTION 5: DISORDERS OF DEVELOPMENT |
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| Chapter 41: PDF file |
- The Molecular And Cellular Genetics Of Autism
- Thomas H. Wassink, James S. Sutcliffe, Veronica J. Vieland And Joseph Piven
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| Chapter 42: PDF file |
- Current And Emerging Therapeutics Of Autistic Disorder And Related Pervasive Developmental Disorders
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| Chapter 43: PDF file |
- Pathophysiology Of Attention-Deficit/Hyperactivity Disorder
- Stephen V. Farone And Joseph Biederman
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| Chapter 44: PDF file |
- Learning Disorders
- C. Keith Conners And Ann C. Schulte
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| Chapter 45: PDF file |
- Psychosis In Childhood And Its Management
- Paramjit T. Joshi And Kenneth E. Towbin
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| Chapter 46: PDF file |
- Behavioral Phenotypes Of Neurodevelopmental Disorders: Portals Into The Developing Brain
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| SECTION 6: SCHIZOPHRENIA AND RELATED DISORDERS |
- Schizophrenia And Related Disorders
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| Chapter 47: PDF file |
- Schizophrenia: Course Over The Lifetime
- Philip D. Harvey And Michael Davidson
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| Chapter 48: PDF file |
- Neurocognitive Functioning In Patients With Schizophrenia: An Overview
- Terry E. Goldberg And Michael F. Green
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| Chapter 49: PDF file |
- Molecular And Population Genetics Of Schizophrenia
- Ming T. Tsuang And Michael J. Owen
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| Chapter 50: PDF file |
- Animal Models Relevant To Schizophrenia Disorders
- Mark A. Geyer And Bita Moghaddam
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| Chapter 51: PDF file |
- Endophenotypes In Studies Of The Genetics Of Schizophrenia
- David L. Braff And Robert Freedman
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| Chapter 52: PDF file |
- Neurochemistry Of Schizophrenia: Glutamatergic Abnormalities
- James H. Meador-Woodruff And Joel E. Kleinman
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| Chapter 53: PDF file |
- Neural Circuitry Approaches To Understanding The Pathophysiology Of Schizophrenia
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| Chapter 54: PDF file |
- Functional Neuroimaging In Schizophrenia
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| Chapter 55: PDF file |
- Structural Magnetic Resonance Imaging Studies In Schizophrenia
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| Chapter 56: PDF file |
- Therapeutics Of Schizophrenia
- Seiya Miyamoto, Gary E. Duncan, Donald C. Goff And Jeffrey A. Lieberman
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| Chapter 57: PDF file |
- The Economics Of The Treatment Of Schizophrenia
- Susan M. Essock, Linda K. Frisman And Nancy H. Covell
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| Chapter 58: PDF file |
- Mechanism Of Action Of Atypical Antipsychotic Drugs
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| Chapter 59: PDF file |
- Neurochemical And Neuropharmacological Imaging In Schizophrenia
- Daniel R. Weinberger And Marc Laruelle
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| SECTION 7: ANXIETY AND STRESS DISORDERS |
- Anxiety And Stress Disorders
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| Chapter 60: PDF file |
- Anxiety And Stress Disorders: Course Over The Lifetime
- Murray B. Stein And Ariel J. Lang
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| Chapter 61: PDF file |
- Genetic And Other Vulnerability Factors For Anxiety And Stress Disorders
- Kathleen R. Merikangas And Daniel Pine
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| Chapter 62: PDF file |
- Animal Models And Endophenotypes Of Anxiety And Stress Disorders
- Vaishali P. Bakshi And Ned H. Kalin
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| Chapter 63: PDF file |
- Neurobiological Basis Of Anxiety Disorders
- Dennis S. Charney And Wayne C. Drevets
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| Chapter 64: PDF file |
- Neural Circuitry Of Anxiety And Stress Disorders
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| Chapter 65: PDF file |
- Structural And Functional Imaging Of Anxiety And Stress Disorders
- Scott L. Rauch And Lisa M. Shin
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| Chapter 66: PDF file |
- Current And Emerging Therapeutics Of Anxiety And Stress Disorders
- Jack M. Gorman, Justine M. Kent And Jeremy D. Coplan
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| Chapter 67: PDF file |
- The Economic Burden Of Anxiety And Stress Disorders
- Ronald C. Kessler And Paul E. Greenberg
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| Chapter 68: PDF file |
- Mechanism Of Action Of Anxiolytics
- John F. Tallman, James Cassella And John Kehne
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| SECTION 8: AFFECTIVE DISORDERS |
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| Chapter 69: PDF file |
- The Course Of Depression
- Robert J. Boland And Martin B. Keller
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| Chapter 70: PDF file |
- Risk Factors For Major Depression And Bipolar Disorder
- Robert M. A. Hirschfeld And Myrna M. Weissman
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| Chapter 71: PDF file |
- Bipolar Disorders: Review Of Molecular Genetic Linkage Studies
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| Chapter 72: PDF file |
- Molecular And Cellular Mechanisms In Depression
- Alan F. Schatzberg, Stephen J. Garlow And Charles B. Nemeroff
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| Chapter 73: PDF file |
- Neurocircuitry Of Mood Disorders
- Gregory A. Ordway, Violetta Klimek And J. John Mann
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| Chapter 74: PDF file |
- Structural And Functional Imaging Of Affective Disorders
- Yvette I. Sheline And Mark A. Mintun
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| Chapter 75: PDF file |
- Current And Emerging Therapeutics For Depression
- A. John Rush And Neal D. Ryan
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| Chapter 76: PDF file |
- Electroconvulsive Therapy: Sixty Years Of Progress And A Comparison With Transcranial Magnetic Stimulation And Vagal Nerve Stimulation
- William M. Mcdonald, W. Vaughn Mccall And Charles M. Epstein
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| Chapter 77: PDF file |
- Current And Emerging Treatments For Acute Mania And Long-Term Prophylaxis For Bipolar Disorder
- Paul E. Keck, Jr. And Husseini K. Manji
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| Chapter 78: PDF file |
- Cost-Effectiveness Of The Newer Generation Of Antidepressants
- Scott W. Woods And C. Bruce Baker
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| Chapter 79: PDF file |
- Mechanism Of Action Of Antidepressants And Mood Stabilizers
- Robert H. Lenox And Alan Frazer
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| Chapter 80: PDF file |
- Hormonal And Gender Influences On Mood Regulation
- David R. Rubinow, Peter J. Schmidt And Catherine A. Roca
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| Chapter 81: PDF file |
- Depression And The Medically Ill
- Robert G. Robinson And K. Ranga Rama Krishnan
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| SECTION 9: ALZHEIMER AND OTHER DEMENTIAS |
- Alzheimer And Other Dementias
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| Chapter 82: PDF file |
- Alzheimer Disease: From Earliest Symptoms To End Stage
- Richard C. Mohs And Vahram Haroutunian
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| Chapter 83: PDF file |
- Molecular Genetics Of Alzheimer Disease
- S. Parvathy And Joseph D. Buxbaum
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| Chapter 84: PDF file |
- Transgenic Mouse Models Of Alzheimer Disease
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| Chapter 85: PDF file |
- Cell And Molecular Neuropathology Of Alzheimer Disease
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| Chapter 86: PDF file |
- Structural And Functional Brain Imaging Of Alzheimer Disease
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| Chapter 87: PDF file |
- Current And Experimental Therapeutics Of Alzheimer Disease
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| Chapter 88: PDF file |
- Alzheimer Disease: Treatment Of Noncognitive Behavioral Abnormalities
- Murray A. Raskind Robert F. Barnes
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| Chapter 89: PDF file |
- Cost-Effectiveness Of Therapeutics For Alzheimer Disease
- Andrea Manca, Linda Davies And Alistair Burns
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| Chapter 90: PDF file |
- Neuropsychiatric Manifestations Of HIV-1 Infection And AIDS
- Dwight L. Evans, Karen I. Mason, Jane Leserman, Russell Bauer And John Petitto
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| Chapter 91: PDF file |
- Dementia With Lewy Bodies
- Ian G. McKeith, David Burn, John O’Brien, Robert Perry And Elaine Perry
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| Chapter 92: PDF file |
- Molecular Pathophysiology Of Stroke
- Steven H. Graham And Robert W. Hickey
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| Chapter 93: PDF file |
- Current And Experimental Treatment Of Stroke
- Daniel L. Small, Paul Morley And Alastair M. Buchan
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| Chapter 94: PDF file |
- Tau Protein And Tauopathy
- Makoto Higuchi, John Q. Trojanowski And Virginia M.-Y. Lee
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| SECTION 10: SUBSTANCE USE DISORDERS |
- Substance Use Disorders
- Charles P. O'Brien And Marian W. Fischman
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| Chapter 95: PDF file |
- Neurocircuitry Of Addiction
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| Chapter 96: PDF file |
- Molecular And Cellular Biology Of Addiction
- Kathy L. Kopnisky And Steven E. Hyman
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| Chapter 97: PDF file |
- Recent Advances In Animal Models Of Drug Addiction
- Toni S. Shippenberg And George F. Koob
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| Chapter 98: PDF file |
- Vulnerability Factors For Alcoholism
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| Chapter 99: PDF file |
- Molecular And Cellular Genetics Of Alcohol Addiction
- Mary-Anne Enoch And David Goldman
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| Ch. 100: PDF file |
- Ethanol Abuse, Dependence, And Withdrawal: Neurobiology And Clinical Implications
- John H. Krystal Boris Tabakoff
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| Ch. 101: PDF file |
- Alcoholism Pharmacotherapy
- Joseph R. Volpicelli, Suchitra Krishnan-Sarin And Stephanie S. O'Malley
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| Ch. 102: PDF file |
- Pathophysiology And Treatment Of Cocaine Dependence
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| Chapter 103: PDF file |
- Application Of Imaging Technologies In The Investigation Of Drug Addiction
- Nora D. Volkow And Joanna S. Fowler
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| Chapter 104: PDF file |
- Molecular And Cellular Neurobiology And Pathophysiology Of Opiate Addiction
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| Chapter 105: PDF file |
- Current And Experimental Therapeutics For The Treatment Of Opioid Addiction
- Paul J. Fudala And George E. Woody
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| Chapter 106: PDF file |
- Marijuana
- Billy R. Martin, William L. Dewey, And Vincenzo Di Marzo
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| Chapter 107: PDF file |
- Therapeutics For Nicotine Addiction
- Reese T. Jones And Neal L. Benowitz
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| Chapter 108: PDF file |
- Psychedelic Drugs
- Henry David Abraham, Una D. Mccann, And George A. Ricaurte
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| Chapter 109: PDF file |
- Epidemiology Of Drug Dependence
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| Chapter 110: PDF file |
- Neuroimaging Of Cocaine Craving States: Cessation, Stimulant Administration, And Drug Cue Paradigms
- A. R. Childress, Teresa R. Franklin, J. Listerud, Paul D. Acton And Charles P. O'Brien
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| SECTION 11: IMPULSIVE AND COMPULSIVE DISORDERS |
- Impulsive And Compulsive Disorders
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| Chapter 111: PDF file |
- The Course And Clinical Features Of Obsessive-Compulsive Disorder
- Steven A. Rasmussen And Jane L. Eisen
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| Chapter 112: PDF file |
- The Pathophysiology And Genetics Of Obsessive-Compulsive Disorder
- David L. Pauls, Emanuela Mundo And James L. Kennedy
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| Chapter 113: PDF file |
- Imaging And Neurocircuitry Of OCD
- David R. Rosenberg And Shauna N. Macmillan
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| Chapter 114: PDF file |
- Current And Experimental Therapeutics Of OCD
- Eric Hollander And Stefano Pallanti
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| Chapter 115: PDF file |
- The Behavioral Neuroscience Of Eating
- Gerard P. Smith And Nori Geary
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| Chapter 116: PDF file |
- Psychopharmacology Of Eating Disorders
- Walter H. Kaye And B. Timothy Walsh
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| Chapter 117: PDF file |
- Tourette Syndrome And Related Tic Disorders
- Neal R. Swerdlow And James F. Leckman
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| Chapter 118: PDF file |
- Animal Models Of Aggression
- Berend Olivier And Larry J. Young
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| Chapter 119: PDF file |
- Pathophysiology And Treatment Of Aggression
- Emil F. Coccaro And Larry J. Siever
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| Chapter 120: PDF file |
- Pathologic Gambling And Impulse Control Disorders
- Mark N. Potenza And Eric Hollander
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| Chapter 121: PDF file |
- Compulsive And Impulsive Aspects Of Self-Injurious Behavior
- Dan J. Stein, Joseph Zohar, And Daphne Simeon
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| SECTION 12: MOVEMENT DISORDERS AND PAROXYSMAL DISORDERS |
- Movement Disorders And Paroxysmal Disorders
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| Chapter 122: PDF file |
- Neurocircuitry Of Parkinson's Disease
- Thomas Wichmann And Mahlon R. Delong
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| Chapter 123: PDF file |
- Pathophysiology Of Parkinson’s Disease
- Michael J. Zigmond And Robert E. Burke
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| Chapter 124: PDF file |
- Current And Experimental Therapeutics Of Parkinson’s Disease
- Jean-Michel Gracies And C. Warren Olanow
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| Chapter 125: PDF file |
- Huntington Disease
- Christopher A. Ross And Russell L. Margolis
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| Chapter 126: PDF file |
- Clinical Course And Cellular Pathology Of Tardive Dyskinesia
- Carol A. Tamminga And Margaret G. Woerner
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| Chapter 127: PDF file |
- Temporal Lobe Epilepsy: Renewed Emphasis On Extrahippocampal Areas
- Robert Schwarcz, Helen E. Scharfman And Edward H. Bertram
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| SECTION 13: CHRONOBIOLOGY AND SLEEP DISORDERS |
- Chronobiology And Sleep Disorders
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| Chapter 128: PDF file |
- Basic Mechanisms Of Sleep: New Evidence On The Neuroanatomy And Neuromodulation Of The Nrem-Rem Cycle
- Edward F. Pace-Schott And J. Allan Hobson
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| Chapter 129: PDF file |
- Circadian Phase Sleep And Mood Disorders
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| Chapter 130: PDF file |
- Sleep Loss And Sleepiness: Physiological And Neurobehavioral Effects
- Jacqueline D. Kloss, Martin P. Szuba And David F. Dinges
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| Chapter 131: PDF file |
- Pathophysiological And Pharmacologic Aspects Of The Sleep Disorder Narcolepsy
- Emmanuel Mignot And Seiji Nishino
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| Chapter 132: PDF file |
- Basic Mechanisms Of Sedative/Hypnotics
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| Chapter 133: PDF file |
- Current And Experimental Therapeutics Of Insomnia
- Daniel J. Buysse And Cynthia M. Dorsey
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| Chapter 134: PDF file |
- Sleep Disturbances Associated With Neuropsychiatric Disease
- Eric A. Nofzinger And Matcheri Keshavan
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