Bortezomib Halts Neuroblastoma Growth

The cancer drug ortezomib inhibits the growth of neuroblastoma cells, a new study reports. Bortezomib is known to work against several adult cancers, but it has never been tried against the childhood tumor neuroblastoma. Mirco Ponzoni, Ph.D., of the G. Gaslini Children's Hospital in Genoa, Italy, and colleagues exposed ten neuroblastoma cell lines and cells from three pediatric patients to bortezomib and watched the drug's effect on cell growth, proliferation, and apoptosis. They found that bortezomib caused tumor cell death and inhibited blood vessel formation, or angiogenesis. Moreover, bortezomib extended the survival of mice in two animal models of human neuroblastoma.

Contact: Mirco Ponzoni, mircoponzoni@ospedale-gaslini.ge.it

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Other highlights in the August 16 JNCI

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Bortezomib Halts Neuroblastoma Growth