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David Julius 教授简介

时间:2006-06-13 11:42来源:http://www.ucsf.edu/djlab/juli 作者:admin 点击: 1217次

David Julius
Professor

Education

1984 Ph.D., University of California, Berkeley, in Biochemistry
1977 B.S., Massachusetts Institute of Technology, in Life Sciences


Research

1999 - present Professor, Department of Cellular & Molecular Pharmacology, UCSF
1996 - 1999 Associate Professor, Department of Cellular & Molecular Pharmacology, UCSF
1989 - 1996 Assistant Professor, Department of Cellular & Molecular Pharmacology University of California, San Francisco
1984 - 1989 Post-doctoral fellow, Institute of Cancer Research, Columbia University, New York. Molecular Analysis of Mammalian Serotonin Receptors Advisor: Dr. Richard Axel
1977 - 1984 Graduate student, Department of Biochemistry, University of California, Berkeley Genetic and Biochemical Analysis of Peptide Hormone Processing and Secretion in Yeast Advisors: Drs. Jeremy Thorner and Randy Schekman
Summer 1976 Visiting Research Associate, Department of Biochemistry, University of Bordeaux, France Purification of tRNA Nucleotidyltransferase from Wheat Germ and Yeast Advisors: Drs. Simon Litvak and Alexander Rich
1975 - 1977 Undergraduate research assistant, Department of Biology, M.I.T. Determining the Isomeric Specificity of tRNA Aminoacylation Advisor: Dr. Alexander Rich.

Awards
2000 First Perl-UNC Neuroscience Prize
2000 15th S. W. Kuffler Lecture, Department of Neurobiology, Harvard Medical School
1999 Louis S. Harris Distinguished Lecture, Medical College of Virginia
1998 Brook Byers Award in Basic Science, UCSF
1998 Sandler Award in Basic Science, UCSF
1998 Presidential Lecture, Society for Neuroscience
1997 Sir Lewis Thomas Pain Lecture, University College London
1997 Syntex Prize in Receptor Pharmacology
1997 McKnight Neuroscience Foundation Investigator Award
1996 Numa Memorial Lecture, Kyoto University, Japan
1990 McKnight Neuroscience Foundation Scholars Award

1990

National Science Foundation Presidential Young Investigator Award
1990 PEW Scholars Award in the Biomedical Sciences
1990 March of Dimes Basil OÕConnor Research Award
1984 Jane Coffin Childs Postdoctoral Fellow
1981 University of California Graduate Studies Award
1976 Eloranta Research Fellow of the Massachusetts Institute of Technology

Publications
Ballivian, L., Julius, D. and Litvak, S. (1976) "The Purification and Properties of Wheat Embryo tRNA Nucleotidyltransferase", in Nucleic Acids and Protein Synthesis in Plants, (Bogorad, L. and J.H. Weil, eds.) CNRS, France, Article number 261.

Julius, D.J., Fraser, T.H. and Rich, A. (1979) Isomeric Specificity of Aminoacylation of Wheat Germ Transfer Ribonucleic Acid and the Specificity of Interaction of Elongation Factor Tu with Aminoacyl Transfer Ribonucleic Acid. Biochemistry 18: 604-609.

Fraser, T.H., Julius, D.J. and Rich, A. (1979) "Determination of Aminoacylation Isomeric Specificity Using tRNA Terminating in 3'-Amino-3'-deoxyadenosine and 2'-Amino-2'-deoxyadenosine", in Methods in Enzymology Volume 59, (Moldave, K. and Grossman, L., eds.) Academic Press, New York, pp. 272-282.

Julius, D., Blair, L., Brake, A., Sprague, G. and Thorner, J. (1983) Yeast Alpha-Factor is Processed from a Larger Precursor Polypeptide: The Essential Role of a Membrane-Bound Dipeptidyl Aminopeptidase. Cell 32: 839-852.

Brake, A., Julius, D. and Thorner, J. (1983) A Functional Prepro-Alpha-Factor Gene in Saccharomyces Yeasts Can Contain Three, Four, or Five Repeats of the Mature Pheromone Sequence. Mol. Cell. Biol. 3: 1440-1450.

Julius, D., Schekman, R. and Thorner, J. (1984) Glycosylation and Processing of Prepro-Alpha-Factor through the Yeast Secretory Pathway. Cell 36: 309-318.

Julius, D., Brake, A., Blair, L., Kunisawa, R. and Thorner, J. (1984) Isolation of the Putative Structural Gene for the Lysine-Arginine-Cleaving Endopeptidase Required for Processing of Yeast Prepro-Alpha-Factor. Cell 37: 1075-1089.

Fuller, R.S., Brake, A.J., Julius, D., and Thorner, J. (1985) "The KEX2 Gene Product Required for Processing of Yeast Prepro-Alpha-Factor is a Calpain-like Endopeptidase Specific for Cleaving at Pairs of Basic Residues", in Current Communications in Molecular Biology: Protein Transport and Secretion. (Gething, M.J. , ed.). Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., pp. 97-102.

Julius, D., MacDermott, A.B., Jessell, T.M. and Axel, R. (1988) Molecular Characterization of a Functional cDNA Encoding the Rat Serotonin 1C Receptor. Science 241: 558-564.

Julius, D., MacDermott, A., Jessell, T., Huang, K., Molineaux, S., Schieren, I. and Axel, R. (1988) "Functional Expression of the 5HT1c Receptor in Neuronal and Non-neuronal Cells" Cold Spring Harbor Symposia on Quantitative Biology: Molecular Biology of Signal Transduction 53: 385-393.

Julius, D., Livelli, T.J., Jessell, T.M. and Axel, R. (1989) Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation. Science 244: 1057-1061.

Molineaux, S., Jessell, T.M., Axel, R. and Julius, D. (1989) The 5HT1c Receptor is a Prominent Serotonin Receptor Subtype in the Central Nervous System. Proc. Natl. Acad. Sci. 86: 6793-6797.

Julius, D., Huang, K.N., Livelli, T., Axel, R. and Jessell, T.M. (1990) The 5HT2 Receptor Defines a Family of Structurally Distinct But Functionally Conserved Serotonin Receptors. Proc. Natl. Acad. Sci. 87: 928-952.

Julius, D. (1990) "Serotonin Receptors: Signal Transduction and Cell Growth", in The Alfred Benzon Symposium 29: Neuropeptides and Their Receptors, (Schwartz, T.W., Hilsted, L.M., and Rehfeld, J.F., eds.) Munksgaard, Copenhagen, pp. 285-298.

Julius, D. and Huang, K.N. (199l) "Molecular Characterization of Three Serotonin Receptors Subtypes", in Serotonin Receptors: Basic and Clinical Aspects (Peroutka, S.J., ed.) Alan R. Liss, New York, NY.

Julius, D. (1991) Molecular Biology of Serotonin Receptors. Annu. Rev. Neurosci. 14: 335-360.

Hsieh, C.-L., Bowcock, A.M., Farrer, L.A., Hebert, J.M., Huang, K.N., Cavalli-Sforza, L.L., Julius, D. and Francke, U. (1990) The Serotonin Receptor Subtype 2 Locus HTR2 is on Human Chromosome 13 Near Genes for Esterase D and Retinoblastoma-1 and on Mouse Chromosome 14. Somatic Cell and Molecular Genetics 16: 567-574.

Maricq, A.V., Peterson, A.S., Brake, A.J., Myers, R.M. and Julius, D. (1991) Primary Structure and Functional Expression of the 5HT3 Receptor, a Serotonin-Gated Ion Channel. Science 254: 432-437.

Milatovich, A., Hsieh, C-L., Bonaminio, G., Tecott, L., Julius, D., and Francke, U. (1992) Serotonin Receptor 1c Gene Assignment to X Chromosome in Human (band q24) and Mouse (bands D - F4). Human Molecular Genetics 1: 681-684.

Tecott, L.H., Maricq, A.V., and Julius, D. (1993) Nervous System Distribution of Serotonin 5HT3 Receptor mRNA. Proc. Natl. Acad. Sci. 90: 1430-1434.

Tecott, L.H. and Julius, D. (1993) A New Wave of Serotonin Receptors. Curr. Opin. Neurobiol. 3: 310-315.

Conklin, B.R., Farfel, Z., Lustig, K.D., Julius, D., and Bourne, H.R. (1993) Substitution of Three Amino Acids Switches Receptor Specificity of Gqa to that of Gia. Nature 363: 274-276.

Lustig, K.D., Shiau, A.K., Brake, A.J., and Julius, D. (1993) Expression Cloning of an ATP Receptor From Mouse Neuroblastoma Cells. Proc. Natl. Acad. Sci. 90: 5113-5117.

Brake, A.J., Wagenbach, M.J. and Julius, D. (1994) New Structural Motif for Ligand-Gated Ion Channels Defined by an Ionotropic ATP Receptor. Nature 371: 519-523.

Burkhalter, A., Julius, D., and Frick, O. (1995) "Histamine, Serotonin, and the Ergot Alkaloids", in Basic & Clinical Pharmacology , Sixth Edition (Katzung, B.G., ed) Appleton and Lange, East Norwalk, Connecticut.

Tecott, L.H., Shtrom, S.S. and Julius, D. (1995) Expression of a Serotonin-Gated Ion Channel in Developing Neural and Non-neural Tissues. Mol. Cell. Neurosci. 6: 43-55.

Tecott, L.H., Sun, L.M., Akana, S.F., Strack, A.M., Lowenstein, D.H., Dallman, M.F., and Julius, D. (l995) Eating Disorder and Epilepsy in Mice Lacking 5-HT2C Serotonin Receptors. Nature 374: 542-546.

Julius, D. (l995) Home for an Orphan Endorphan. - News & Views. Nature 377: 476

Brake, A., Schumacher, M. and Julius, D. (1996) ATP Receptors in Sickness, Pain, and Death. Chem. & Biol. 3: 229-232.

Brake, A.J. and Julius, D. (l996) Signaling by Extracellular Nucleotides. Annu. Rev. Cell Dev. Biol. 12: 519-541.

Julius, D. (l997) Another Opiate for the Masses? - News & Views. Nature 386: 442.

Caterina, M.C., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D., and Julius, D. (1997) The Capsaicin Receptor: A Heat-Activated Ion Channel in the Pain Pathway. Nature 389: 816-824.

England, L.E., Imperial, J., Jacobsen, R., Craig, A.G., Gulyas, J., Akhtar, M., Rivier, J., Julius, D., and Olivera, B. (1998) Inactivation of a Serotonin-Gated Ion Channel by a Novel Polypeptide Toxin from Marine Snails, Science 281: 575-578.

Bedford, F.K., Julius, D., and Ingraham, H.A. (1998) Neuronal Expression of the 5-HT3 Receptor Gene Requires Nuclear Factor 1 Complexes, J. Neurosci. 18: 6186-6194.

Tominaga, M., Caterina, M.C., Malmberg, A., Rosen, T.A., Gilbert, H., Skinner, K., Basbaum, A.I., and Julius, D. (1998) The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli. Neuron 21: 531-543.

Julius, D. (1998) Serotonin Receptor Knockouts: A Moody Subject Ð Commentary. Proc. Natl. Acad. Sci. 95: 15153-15154.

Caterina, M.J., Rosen, T.A., Tominaga, M., Brake, A.J., and Julius, D. (1999) Identification of a capsaicin receptor homologue with a high threshold for noxious heat. Nature 398: 436-441.

Zygmunt, P., Petersson, J., Andersson, D., Chuang, H-h., S¿rgŒrd, M., Di Marzo, V., Julius, D., and Hšgestþtt, E. (l999) Vanilloid Receptors on Sensory Nerves Mediate the Vasodilator Action of Anandamide. Nature 400: 452-457.

Caterina, M.J. and Julius, D. (1999) Sense and specificity: A Molecular Identity for Nociceptors. Curr. Opin. Neurobiol. 9: 525-530.

Melck D, Bisogno T, De Petrocellis L, Chuang H, Julius D, Bifulco M, Di Marzo V (1999) Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. Biochem Biophys Res Commun 262 :275-84.

Zygmunt PM, Chuang H, Movahed P, Julius D, Hogestatt ED (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur J Pharmacol 396:39-42.

Caterina, M.J. Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K., Koltzenburg, M., Basbaum, A.I., and Julius, D. (2000) Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor. Science 288: 306-313.

Jordt, S-E., Tominaga, M., and Julius, D. (2000) Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc. Natl. Acad. Sci. 97: 8134-8139.

Caterina, M.J. and Julius, D. (2001) The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway. Annu. Rev. Neurosci. 24: 487-517.

Hollopeter. G., Jantzen, H-M., Vincent, D., Li, G., England, L., Ramakrishnan, V., Yang, R-B., Nurden, P., Nurden, A., Julius, D. and Conley, P.B., (2001) Molecular Identification of the Platelet ADP Receptor Targeted by Antithrombotic Drugs. Nature 409: 202-207.

Chuang, H., Prescott, E.D., Kong, H., Shields, S., Jordt, S.E., Basbaum, A.I., Chao, M.V., and Julius, D. (2001) Bradykinin and Nerve Growth Factor Release the Capsaicin Receptor from PtdIns(4,5)P2-mediated Inhibition. Nature 411: 957-962.

Julius, D. and Basbaum, A.I. (2001) Insight Review: Molecular Mechanisms of Nociception. Nature 413: 203-210.

Zeitz, K.P., Guy, N., Malmberg, A.B., Dirajlal, S., Martin, W.J., Sun, L., Bonhaus, D.W., Stucky, C.L., Julius, D. and Basbaum, A.I. (2002) The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J. Neurosci. 22: 1010-1019.

Jordt, S-E. and Julius, D. (2002) Molecular basis of species-specific sensitivity to ÒhotÓ chili peppers. Cell 108: 421-430.

McKemy, D.D., Neuhausser, W.M., and Julius, D. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature (Article) - advanced on-line publication, Feb. 10.
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