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Lu kun ping(卢坤平)教授简介

时间:2006-06-14 17:39来源:MIT 作者:admin 阅读:

 
Dr. Kun Ping Lu Associate Professor

Harvard Medical School
Department of Medicine
Beth Israel Deaconess Medical Center
Harvard Institutes of Medicine, Room 1047
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: (617) 667-4143
Fax: (617) 667-0610
Email: [email protected]
 
卢坤平,现任美国哈佛大学医学院副教授、Beth Israel Deaconess 医学中心医学部Ping Lu实验室负责人,美国国立卫生研究院、中国国家自然科学基金委、哈佛大学Beth Israel Deaconess 医学中心等五个专业委员会会委员;《Nature》、《EMBO》等数十个国际著名科技期刊审稿人。2005年被聘为南方医科大学生物化学与分子生物学专业特聘教授,并推荐为2005年长江学者讲座教授。获得各项研究经费980万美元。发现了一个以个人名字命名的重要基因家族(pin 1, 2..X)及其表达产物,并在此基础上,研究了细胞周期调节及端粒酶调控的分子机制,为阐明Pin系列蛋白质与癌症以及Alzheimer病的重要关系做出贡献。发现了Pin系列蛋白质在肿瘤和衰老过程中的重要作用。所取得的原创性突破得到学术界公认,先后在SCI收录的高影响因子期刊上共发表论文52篇,其中《Cell》3篇,《Nature》7篇,《Science》2篇。申请美国专利11项,其中2项已获得授权。
 

Education:

1979-1984 M.D. Fujian Medical College (P. R. China)
1984-1987 M.Sc. (Pharmacology) Suzhou Medical College (P. R. China)
1989-1992 Ph.D. (Cell Biology) Duke University

Postdoctoral Training:

1993-1996 Research Associate, Molecular Biology, Salk Institute
 
Field Of Research:

Cell Cycle Control and Tumorigenesis

Research Interest:

Cell proliferation is regulated by several control points, termed checkpoints, and deregulation of these checkpoints may lead to cancer. Protein phosphorylation by the mitotic kinase Cdc2, mainly on Ser/Thr-Pro motifs, plays an essential role in triggering a programmed set of mitotic events. We have recently cloned two novel genes, Pini and Pin2, involved in mitotic regulation. Pini is a novel and conserved peptidyl-prolyl isomerase that specifically catalyzes prolyl isomerization of the phosphorylated Ser/Thr-Pro bond and is the only PPIase documented to be essential for cell survival. Pini uses its N-terminal WW domain, a novel phosphoserine-binding module, to interact with a defined subset of mitosis-specific phosphoproteins, including Cdc2 regulators and substrates. Furthermore, Pini regulates the activity of phosphoproteins and controls the timing of mitotic entry, presumably by phosphorylation-dependent prolyl isomerization. Thus, Pini is a novel post-phosphorylation regulator. Pin2 is a major expressed product of the Pin2/TRF1 gene, which regulates maintenance of telomeres. Telomeres are genetic elements that are essential for preserving chromosome integrity and are implicated in mitotic checkpoint control. Interestingly, Pin2 is also involved in regulation of mitosis. Pin2 interacts with and is also phosphorylated by the ATM protein kinase, encoded by the gene responsible for the human genetic disorder ataxia telangiectasia. This autosomal recessive disorder displays a wide range of abnormalities, including genomic instability, cell cycle checkpoint defects and predisposition to cancer and aging, which are believed to be related to telomere dysfunction. Based on the above findings, we hypothesize that Pini and Pin2 play critical roles in coordinating telomere maintenance and cell division, whose aberrations contribute to oncogenesis. To test this hypothesis, we will :

  1. elucidate the molecular mechanism of Pin 1-dependent mitotic regulation,
  2. determine the role of the Pin2 and ATM interaction in regulating the cell cycle and telomere maintenance, and
  3. evaluate the role of Pin 1 and Pin2 in cancer. These studies should help us understand the molecular mechanisms underlying control of the cell cycle and oncogenesis, and may eventually lead to the development of new therapeutic reagents

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