题名: |
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. |
作者: |
He JS, Meyer-Hermann M, Xiangying D, et al. |
单位: |
Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore 138648 |
出处: |
The Journal of Experimental Medicine,2013,210(12):2755-2771 |
语种: |
英文 |
文摘: |
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. IgE(+) B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE(+) GC B cells are unfit to undergo the conventional GC differentiation program due to impaired B cell receptor function and increased apoptosis. IgE(+) GC cells fail to populate the GC light zone and are unable to contribute to the memory and long-lived PC compartments. Furthermore, we demonstrate that direct and sequential switching are linked to distinct B cell differentiation fates: direct switching generates IgE(+) GC cells, whereas sequential switching gives rise to IgE(+) PCs. We propose a comprehensive model for the generation and memory of IgE responses.
http://dx.doi.org/10.1084/jem.20131539 |
关键词: |
germinal center phase; IgE+ B lymphocytes; classical memory response |
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