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ISRAEL SILMAN Ph.D.(3)

时间:2007-03-15 09:31来源:internet 作者:bioguider 点击: 361次

38.    Felder CE, Harel M, Silman I, Sussman JL. (2002) Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase. Acta Crystallogr D Biol Crystallogr. 58(Pt 10 Pt 2):1765-71.

39.    Dvir H, Jiang HL, Wong DM, Harel M, Chetrit M, He XC, Jin GY, Yu GL, Tang XC, Silman I, Bai DL, Sussman JL. (2002) X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement. Biochemistry. 41(35):10810-8.

40.    Shin I, Wachtel E, Roth E, Bon C, Silman I, Weiner L. (2002) Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding? Protein Sci. 11(8):2022-32.

41.    Koellner G, Steiner T, Millard CB, Silman I, Sussman JL. (2002) A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica. J Mol Biol. 320(4):721-5.  

42.    Bar-On P, Millard CB, Harel M, Dvir H, Enz A, Sussman JL, Silman I. (2002) Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine. Biochemistry. 41(11):3555-64.

43.    Dvir H, Wong DM, Harel M, Barril X, Orozco M, Luque FJ, Munoz-Torrero D, Camps P, Rosenberry TL, Silman I, Sussman JL. (2002) 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates. Biochemistry. 41(9):2970-81.

44.    Slutsky I, Silman I, Parnas I, Parnas H. (2001) Presynaptic M(2) muscarinic receptors are involved in controlling the kinetics of ACh release at the frog neuromuscular junction. J Physiol. 536(Pt 3):717-25. 

45.    Weik M, Ravelli RB, Silman I, Sussman JL, Gros P, Kroon J. (2001) Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes. Protein Sci. 10(10):1953-61.

46.    Doucet-Personeni C, Bentley PD, Fletcher RJ, Kinkaid A, Kryger G, Pirard B, Taylor A, Taylor R, Taylor J, Viner R, Silman I, Sussman JL, Greenblatt HM, Lewis T. (2001) A structure-based design approach to the development of novel, reversible AChE inhibitors. J Med Chem. 44(20):3203-15.

47.    Nicolas A, Ferron F, Toker L, Sussman JL, Silman I. (2001) Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase. Acta Crystallogr D Biol Crystallogr. 57(Pt 9):1348-50.

48.    De Ferrari GV, Canales MA, Shin I, Weiner LM, Silman I, Inestrosa NC. (2001) A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation. Biochemistry. 40(35):10447-57.

49.    Weik M, Kryger G, Schreurs AM, Bouma B, Silman I, Sussman JL, Gros P, Kroon J. (2001) Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures. Acta Crystallogr D Biol Crystallogr. 57(Pt 4):566-73. 

50.    Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL. (2000) Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. Acta Crystallogr D Biol Crystallogr. 56(Pt 11):1385-94.

51.    Harel M, Kryger G, Rosenberry TL, Mallender WD, Lewis T, Fletcher RJ, Guss JM, Silman I, Sussman JL. (2000) Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors. Protein Sci. 9(6):1063-72.

52.    Kraut D, Goff H, Pai RK, Hosea NA, Silman I, Sussman JL, Taylor P, Voet JG. (2000) Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride. Mol Pharmacol. 57(6):1243-8.

53.    Koellner G, Kryger G, Millard CB, Silman I, Sussman JL, Steiner T. (2000) Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica. J Mol Biol. 296(2):713-35.

54.    Weik M, Ravelli RB, Kryger G, McSweeney S, Raves ML, Harel M, Gros P, Silman I, Kroon J, Sussman JL. (2000) Specific chemical and structural damage to proteins produced by synchrotron radiation. Proc Natl Acad Sci U S A. 97(2):623-8.

55.    Arnon R, Silman I, Tarrab-Hazdai R. (1999) Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthday. Protein Sci. 8(12):2553-61. Review.

56.    Greenblatt HM, Kryger G, Lewis T, Silman I, Sussman JL. (1999) Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 463(3):321-6.

57.    Tarrab-Hazdai R, Toker L, Silman I, Arnon R. (1999) Acetylcholinesterase from Schistosoma mansoni: interaction of globular species with heparin. Biochem J. 344 Pt 3:945-51.

58.    Botti SA, Felder CE, Lifson S, Sussman JL, Silman I. (1999) A modular treatment of molecular traffic through the active site of cholinesterase. Biophys J. 77(5):2430-50.

59.    Weiner L, Roth E, Mazur Y, Silman I. (1999) Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin. Biochemistry. 38(35):11401-5.

60.    Silman I, Millard CB, Ordentlich A, Greenblatt HM, Harel M, Barak D, Shafferman A, Sussman JL. (1999) A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase. Chem Biol Interact. 119-120:43-52. Review.

61.     Kryger G, Silman I, Sussman JL. (1999) Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure. 7(3):297-307.

62.    Millard CB, Kryger G, Ordentlich A, Greenblatt HM, Harel M, Raves ML, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL. (1999) Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level. Biochemistry. 38(22):7032-9.

63.    Morel N, Bon S, Greenblatt HM, Van Belle D, Wodak SJ, Sussman JL, Massoulie J, Silman I. (1999) Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase. Mol Pharmacol. 55(6):982-92.

64.    Ravelli RB, Raves ML, Ren Z, Bourgeois D, Roth M, Kroon J, Silman I, Sussman JL. (1998) Static Laue diffraction studies on acetylcholinesterase. Acta Crystallogr D Biol Crystallogr. 54(Pt 6 Pt 2):1359-66.

65.    Kryger G, Silman I, Sussman JL. (1998) Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica. J Physiol Paris. 92(3-4):191-4.

66.    Botti SA, Felder CE, Sussman JL, Silman I. (1998) Electrotactins: a class of adhesion proteins with conserved electrostatic and structural motifs. Protein Eng. 11(6):415-20. Review.

67.    Felder CE, Botti SA, Lifson S, Silman I, Sussman JL. (1997) External and internal electrostatic potentials of cholinesterase models. J Mol Graph Model. 15(5):318-27, 335-7.

68.    Shin I, Silman I, Bon C, Weiner L. (1998) Liposome-catalyzed unfolding of acetylcholinesterase from Bungarus fasciatus. Biochemistry. 37(13):4310-6.

69.    Shin I, Kreimer D, Silman I, Weiner L. (1997) Membrane-promoted unfolding of acetylcholinesterase: a possible mechanism for insertion into the lipid bilayer. Proc Natl Acad Sci U S A. 94(7):2848-52.

70.    Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL. (1997) Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat Struct Biol.4(1):57-63.

71.    Kreimer DI, Shin I, Shnyrov VL, Villar E, Silman I, Weiner L. (1996) Two partially unfolded states of Torpedo californica acetylcholinesterase. Protein Sci. 5(9):1852-64.

72.    Peng L, Silman I, Sussman J, Goeldner M. (1996) Biochemical evaluation of photolabile precursors of choline and of carbamylcholine for potential time-resolved crystallographic studies on cholinesterases. Biochemistry. 35(33):10854-61.

73.    Faerman C, Ripoll D, Bon S, Le Feuvre Y, Morel N, Massoulie J, Sussman JL, Silman I. (1996) Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function. FEBS Lett. 386(1):65-71.

74.    Porschke D, Creminon C, Cousin X, Bon C, Sussman J, Silman I. (1996) Electrooptical measurements demonstrate a large permanent dipole moment associated with acetylcholinesterase. Biophys J. 70(4):1603-8.

75.    Shin I, Silman I, Weiner LM. (1996) Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes. Protein Sci. 5(1):42-51.

76.    Harel M, Kleywegt GJ, Ravelli RB, Silman I, Sussman JL. (1995) Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target. Structure. 3(12):1355-66.

77.    Kreimer DI, Shnyrov VL, Villar E, Silman I, Weiner L. (1995) Irreversible thermal denaturation of Torpedo californica acetylcholinesterase. Protein Sci. 4(11):2349-57.

78.    Eichler J, Silman I. (1995) The activity of an endoplasmic reticulum-localized pool of acetylcholinesterase is modulated by heat shock. J Biol Chem. 270(9):4466-72.

79.    Eichler J, Tolliday N, Toker L, Silman I. (1995) Purification and characterization of HSP70 proteins from Torpedo electric organ. Comp Biochem Physiol B Biochem Mol Biol. 110(2):409-15.  (责任编辑:泉水)
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