阿根廷布宜诺斯艾利斯大学和巴西南大河州天主教主教大学的科学家,在对老鼠注射了超剂量的蛋白质脑源性神经营养因子(BDNF)后发现,老鼠记忆在大脑中的持续过程从7倍提高到10倍,也就是说,蛋白质可以决定记忆在大脑中持续时间的长短。相关科研成果发表在近期的《美国国家科学院刊》上。
原始出处: BDNF is essential to promote persistence of long-term memory storage Pedro Bekinschtein*, Martín Cammarota, Cynthia Katche*, Leandro Slipczuk*, Janine I. Rossato, Andrea Goldin*, Ivan Izquierdo,, and Jorge H. Medina*, *Instituto de Biología Celular y Neurociencias and Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina; and Centro de Memória, Instituto de Pesquisas Biomédicas, Pontifical Catholic University of Rio Grande do Sul, RS 90610-1121 Porto Alegre, Brazil Contributed by Ivan Izquierdo, December 20, 2007 (sent for review November 30, 2007) Abstract
Persistence is a characteristic attribute of long-term memories (LTMs). However, little is known about the molecular mechanisms that mediate this process. We recently showed that persistence of LTM requires a late protein synthesis- and BDNF-dependent phase in the hippocampus. Here, we show that intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis. Importantly, we demonstrate that BDNF induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner. Thus, BDNF is not only necessary, but sufficient to induce a late postacquisition phase in the hippocampus essential for persistence of LTM storage.
consolidation | hippocampus | forgetting | ERK1/2
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