Principal Investigator Kriegstein, Arnold&nbs

Principal Investigator/Program Director (Last, First, Middle): Kriegstein, Arnold R.

NAME
Arnold R. Kriegstein, M.D., Ph.D.
POSITION TITLE
Director, Institute for Regeneration Medicine, UCSF
INSTITUTION AND LOCATION
Yale University, New Haven, Connecticut B.A. 1971 Biology
New York University, New York M.S. 1974 Physiology
New York University, New York Ph.D. 1977 Physiology
New York University, New York M.D. 1977 Medicine
A. Positions and Honors.
Positions
1978-81 Neurology Resident, Harvard Longwood Area Program, Peter Bent Brigham Hospital, Beth
Israel Hospital, and Boston Children's Hospital, Boston, MA
1981-88 Assistant Professor of Neurology, Stanford University, Dept. of Neurology, Stanford, CA
1991-93 Clinical Associate Professor, Department of Neurology, Yale University, New Haven, CT
1991-93 Assoc. Research Scientist, Dept. of Neurobiology, Yale University, New Haven, CT
1994-99 Associate Professor of Neurology, College of Physicians & Surgeons of Columbia University,
Jointly appointed in the Departments of Neurology and Pathology and the Center for
Neurobiology & Behavior, NY, NY
1999-01 Professor of Neurology, College of Physicians & Surgeons of Columbia University, NY, NY
2001-04 John and Elisabeth Harris Professor of Neurology (in Pathology and in the Center for
Neurobiology and Behavior), College of Physicians & Surgeons of Columbia University
2004- Professor of Neurology, University of California, San Francisco, CA
2004- Director, Institute for Regeneration Medicine, UCSF, San Francisco, CA
Honors
1982-84 Mellon Scholar
1986 Stanford University William M. Hume Faculty Scholar
1987-89 Visiting Professor of Neurology and Lecturer in Clinical Neuroscience, University of Bari, Italy,
appointed by the Italian Ministry for Public Education
1991 Wellcome Research Travel Award to Britain
1999 Javits Neuroscience Investigator Award
B. Selected peer-reviewed publications (in chronological order).
1. Lo Turco JJ, Kriegstein AR. Clusters of coupled neuroblasts in embryonic neocortex. Science
1991;252:563-566.
2. LoTurco JJ, Owens DF, Heath MJS, Davis MBE, Kriegstein AR. GABA and glutamate depolarize
cortical progenitor cells and inhibit DNA synthesis. Neuron 1995;15:1287-1298.
3. Kriegstein AR, Armitage BA, Kim PY. Heroin inhalation and progressive spongiform
leukoencephalopathy. NEJM 1997;336(8):589.
4. Bittman K, Owens DF, Kriegstein AR, LoTurco, JJ. Cell coupling and uncoupling in the ventricular
zone of developing neocortex. J Neuroscience 1997;17(18):7037-44.
5. Flint AC, Liu X, Kriegstein AR. Nonsynaptic activation of glycine receptors by taurine during
neocortical development. Neuron 1998;20:43-53.
6. Owens DF, Kriegstein AR. Patterns of Intracellular Calcium Fluctuation in Precursor Cells of the
Neocortical Ventricular Zone. J Neuroscience 1998;18(14):5374-5388.
7. Kriegstein AR, Shungu DC, Millar WS, Armitage BA, Brust JC, Chillrud S, Goldman J, Lynch T.
Leukoencephalopathy and raised brain lactate from heroin vapor inhalation (Chasing the Dragon).
Neurology 1999;53(8):1765-1773.
Principal Investigator/Program Director (Last, First, Middle): Kriegstein, Arnold R.
PHS 398/2590 (Rev. 09/04) Page 10 Continuation Format Page
8. Flint AC, Dammerman RS, Kriegstein AR. Endogenous activation of metabotropic glutamate receptors
in neocortical development causes neuronal calcium oscillations. PNAS 1999;96(21):12144-12149.
9. Dammerman RS, Noctor SC, Kriegstein AR. Extrinsic GABAergic innervation of developing
neocortical layer 1 in organotypic slice co-cultures. J Comp Neurol 2000;423(1):112-120.
10. Dammerman RS, Flint AC, Noctor SC, Kriegstein AR. An excitatory GABAergic projection to
developing neocortical layer 1. J Neurophysiology 2000;84(1):428-434.
11. Noctor SC, Flint AC, Weissman TA, Dammerman RS, Kriegstein AR. Neurons derived from radial glial
cells establish radial units in neocortex. Nature 2001;409:714-20.
12. Noctor SC, Flint AC, Weissman TA, Wong WS, Clinton BK, Kriegstein AR. Dividing precursor cells of
the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia.
J Neuroscience 2002;22(8):3161-73.
13. Owens DF, Kriegstein AR. Is there more to GABA than synaptic inhibition? Nature Rev Neurosci
2002;3(9):715-27.
14. Owens DF, Kriegstein AR. Developmental neurotransmitters? Neuron 2002;36:989-91.
15. Fishell G, Kriegstein AR. Neurons from radial glia: The consequences of asymmetric inheritance.
Current Opinion in Neurobiology 2003;13:34-41.
16. Weissman T, Noctor SC, Clinton BK, Honig LS, Kriegstein AR. Neurogenic radial glial cells in reptile,
rodent, and human: from mitosis to migration. Cerebral Cortex 2003;13:550-9.
17. Kriegstein AR, Parnavelas JG. Changing concepts of cortical development. Cerebral Cortex
2003;13:541.
18. Kriegstein AR, Gotz M. Radial glia diversity: A matter of cell fate. Glia 2003;43:37-43.
19. Ivic L, Sands TT, Fishkin N, Nakanishi K, Kriegstein AR, Stromgaard K. Terpene trilactones from
Ginkgo biloba are antagonists of cortical glycine and GABAA receptors. J Biol Chem 2003;278:49279-
85.
20. Noctor SC, Martínez-Cerdeño V, Ivic L, Kriegstein AR. Cortical neurons arise in symmetric and
asymmetric division zones and migrate through specific phases. Nature Neuroscience 2004;7:136-
44.
21. Kriegstein AR, Noctor SC. Patterns of neuronal migration in the embryonic cortex. TINS 2004;27:392-9.
22. Weissman TA, Ivic L, Riquelme PA, Flint AC, Kriegstein AR. Calcium waves propagate through radial
glial cells in the developing neocortex. Neuron 2004;43:647-61.
23. Kriegstein AR, Castañeda-Castellanos, DR, Noctor SC. Patterns of cortical neurogenesis. Clinical
Neurosci Res 2004;4:2-8.
24. Castañeda-Castellanos DR, Kriegstein AR. Controlling neuron number: Does Numb do the math?
Nature Neuroscience 2004;7:793-4.
25. Butt, SJ, Fuccillo M, Nery S, Noctor S, Kriegstein A, Corbin JG, Fishell G. The temporal and spatial
origins of cortical interneurons predict their physiological subtype. Neuron 2005;48(4):591-604.
26. Lo B, Zettler P, Cedars MI, Gates E, Kriegstein AR, Oberman M, Reijo Pera R, Wagner RM, Wuerth
MT, Wolf LE, Yamamoto KR. A new era in the ethics of human embryonic stem cell research. Stem
Cells 2005;23(10)1454-9.
27. Kriegstein AR. Constructing circuits: neurogenesis and migration in the developing neocortex.
Epilepsia 2005;46 Supplement 7:15-21.
28. Tsai JW, Chen Y, Kriegstein AR, Vallee RB. LIS1 RNA interference blocks neural stem cell division,
morphogenesis, and motility at multiple stages. J Cell Biol 2005;170(6):935-45.
29. Kriegstein, AR. GABA puts the brake on stem cells. Nature Neuroscience 2005;8(9):1132-3.
30. Fishell G, Kriegstein A. Cortical development: new concepts. Neuron 2005;46(3):361-2.
31. Kriegstein AR, Parnavelas JG. Progress in corticogenesis. Cerebral Cortex 2006; Suppl 1:1-2.
32. Martinez-Cerdeno V, Noctor SC, Kriegstein AR. The role of intermediate progenitor cells in the
evolutionary expansion of the cerebral cortex. Cerebral Cortex 2006;Suppl 1:152-61.
33. Young-Pearse TL, Ivic L, Kriegstein AR, Cepko CL. Characterization of mice with targeted deletion of
glycine receptor alpha 2. Mol Cell Biol 2006;26:5728-34.
34. Kriegstein AR, Noctor SC, Martinez-Cerdeno. Patterns of neural stem and progenitor cell division may
underlie evolutionary cortical expansion. Nat Rev Neuroscience 2006; 7(11):883-90.

Ongoing Research Support
R01 NS21223 Kriegstein (PI) 12/01/84-06/30/08
NIH/NINDS
Intercellular Signaling in Neocortical Development.
These experiments are designed to illuminate how epigenetic signals, including amino acid neurotransmitters
and their receptors, influence critical events in early corticogenesis, as well as the mechanisms regulating
symmetrical and asymmetrical cell divisions.
Role: PI
R01 NS35710 Kriegstein (PI) 04/01/97-01/31/11
NIH/NINDS
The Physiology of Radial Units in Corticogenesis.
This project aims to address questions concerning the clonal relationship of neural progenitor cells and their
daughter neurons. A particular focus is the role of gap junctions in cortical development.
Role: PI
P01 NS Ross (PI) 04/05/99-06/30/07
NIH/NINDS
Microcephaly: Brain Formation and Behavior
This project examines the dynamics of proliferation in the embryonic telencephalon in normal and mutant
mice to gain insights into mechanisms that regulate neurogenesis in health and disease. Specific subsets of
neocortical neurons arise from spatially distributed proliferative zones and involve distinct molecular signals.
Role: Co-PI
W81 XWH-06-TSCRP-IDA Kriegstein (PI) 11/01/06-10/31/09
DOD Army Medical Research Activity
The role of Tuberin and Hamartin in Cortical Neuron Migration.
This project will help to insight into appropriate therapeutic targets for prevention and/or amelioration of CNS
manifestations tuberous sclerosis complex.
Role: PI
Completed Research Support
R37 NS38658 Kriegstein (PI) 04/05/99-03/31/06
NIH/NINDS
Glycine Receptors and Disorders of Corticogenesis.
This project was designed to explore the role of cortical glycine receptors during embryonic and perinatal
stages of cortical development.
Role: PI
Citizens United for Research in Epilepsy Kriegstein (PI) 01/01/05-12/31/05
Pathogenesis of Cortical Lesions in a Model of Tuberous Sclerosis.
This study addressed the mechanisms by which the gene defects in tuberous sclerosis lead to disorders of
cell proliferation and migration.
Role: PI
Lieber Foundation Kriegstein (PI) 2000-2004
Neurodevelopmental Mechanisms that may Underlie Schizophrenia.
This project explored the role of NMDA receptors at early stages of cortical development.
Role: PI (责任编辑：泉水)

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Principal Investigator Kriegstein, Arnold&nbs