Li min Chen Ph.D., M.D. 陈立敏助理教授

Li Min Chen M.D., Ph.D.
Department of Radiology and Radiological Science, Institute of Imaging Science, Vanderbilt University, 1161 21st Ave. South, MCN, AA 3115, Nashville, TN, 37232-2310, Email: limin.chen@vanderbilt.edu
Education
1994–1997 Ph.D. Institute of Neuroscience, 4th Military Medical University, Xi’an, China
• Specialty: Neuroscience.
• Thesis: The role of Ca2+ active K+ channel in the generation of hypersensitivity of neuron in dorsal root ganglion of chronic neuropathic pain model in rat.
1989-1992 Master Dept. of Physiology, 4th Military Medical University, Xi’an, China
• Specialty: Neurophysiology
• Thesis: Ionic channels involvement in the hypersensitization of C-polymodel nociceptors in inflammatory pain model of rats.
1983–1989 M.D. 4th Military Medical University, Xi’an, China
• Clinical Medicine
Research experience
2006 – present Assistant Professor (tenure track). Dept of Radiology and Radiological Science, Institute of Imaging Science, Vanderbilt University.
• Functional MRI of touch and nociception on anesthetized and awake monkeys.
• Understanding Cortical mechanism underlying pain and tactile perception revealed by multiple approaches (including functional MRI, intrinsic and voltage-sensitive dye, single and multiple unit electrophysiological recording).
• High field fMRI of touch and pain in human subjects.
2005 – 2006 Research Assistant Professor Dept. of Psychology, Vanderbilt University, Institute of Imaging Science, Vanderbilt University Medical Center.
• Cortical mechanism underlying pain and tactile perception revealed by multiple approaches (including functional MRI, intrinsic and voltage-sensitive dye, single and multiple unit electrophysiological recording).
• Functional imaging (fMRI and optical imaging) on anesthetized and awake rats and monkeys.
2003 – 2005 Senior Research Associate Dept. of Psychology, Vanderbilt University.
• Cortical mechanism underlying pain and tactile perception.
• In vivo fMRI and optical imaging on anesthetized and awake monkey
2002– 2003 Associate Research Scientist Dept. of Neurobiology, Yale University, School of Medicine
• Cortical mechanism underlying pain and tactile perception.
• In vivo optical imaging and electrophysiology on cortex of awake behavioral and anesthetized monkeys.
1998– 2002 Postdoctoral Fellow Dept. of Neurobiology, Yale University, School of Medicine
• Cortical mechanism underlying pain and tactile perception.
• In vivo optical imaging and electrophysiology on cortex of awake behavioral and anesthetized monkeys.
Teaching experience
2006-present Assistant Professor. Departments of Radiology and Radiological Science, and Psychology.
• Lecturer for Neuroscience Graduate Program at Vanderbilt University
• Teaching system neuroscience
1997-1998 Lecturer Dept. of Physiology, 4th Military Medical University, China
• Director of Human Physiology education. Giving lecture for over 300 medical students and students of nursing school.
• Supervising researches of graduate students.
• Teaching “Neurophysiology” course for graduate students in master degree program.
1992–1994 Assistant Lecturer Dept. of Physiology, 4th Military Medical University, China
• Teaching “ Human Physiology” course for students of nursing school.
• Teaching “ Animal Experimental Physiology” course for medical students.
• Organizing and teaching “Neurophysiology” course for graduate students in master degree program.
Awards and Honors
2008: NIH (NIDA). R21 grant. Title of the proposal “High Resolution fMRI of Nociception in SII of monkeys”.
2005: NIH (NIDCR), R03 grant. Title of the proposal “optical imaging of mechanical nociception in SI cortex”.
2002: Title of prestigious national award: The Prize of Science & Technology Progress of People’s Liberation Army of China. Project: The Periphery Regulating Mechanism of Chronic Pain.
Role: major contributor.
1999: Yale University Brown-Coxe Postdoctoral fellowship.
1997: Outstanding Teacher Award in 4th Military Medical University, China
1994: Title of prestigious national award: The Prize of Science & Technology Progress of People’s Liberation Army of China. Project: The Peripheral Modulation of Nociceptors.
Role: major contributor.
Membership
American Society for Neuroscience; International Association for the Study of Pain;
Publication list
Friedman RM, Chen LM, Roe AW. Responses in Area 1 in anesthetized aquirrel monkeys to single and dual site stimulation of the digits. J Neurophysi (in press)
Chen LM, Turner G, Friedman RM, Zhang N, Gore JC, Roe A, Avison MJ. High resolution maps of real and illusory tactile activation in SI in individual monkeys with fMRI and optical imaging. 2007 J Neurosci 27(34): 9181-91
Zhang N, Gore JC, Chen LM, Avison MJ. (2007) Dependence of BOLD signal shange on tactile stimulus intensity in SI of primate cortex. Magn Reson Imaging. 2007 25(6): 784-94
Chen LM, Friedman RM, Roe AW. Optical imaging of SI topography in anesthetized and awake squirrel monkey. J Neurosci. 2005 25(33):7648-7659.
Friedman RM, Chen LM, Roe AW. Modular Organization of Tactile Submodalities within Area 1. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12724-9.
Schwartz TH, Chen LM, Friedman RM, Spencer DD, Roe AW. (2004) Intraoperative Optical Imaging of Face Topography in Human Somatosensory Cortex. NeuroReport 2004; 15: 1527-1532
Chen LM, Friedman RM, and Roe AW. (2003) Optical imaging of a tactile illusion in Area 3b of the primary somatosensory cortex. Science 302: 881-885
Chen LM, Heider B, Healy FL, Williams GV, and Roe AW (2002) A chamber implants for long-term optical imaging in awake monkeys. J Neuroscience Method. 113:41-49.
Chen LM, Friedman RM, Ramsden BM, LaMotte RH and Roe AW (2001) Fine-scale organization of SI cortex (Area 3b) in the squirrel monkey revealed with intrinsic optical imaging. J. Neurophysiol. 86:3011-3029.
Hung CP, Ramsden BM, Chen LM, and Roe AW (2001) Building Surfaces from Borders in Areas 17 and 18 of the Cat. Vision Research. 41:1389-1407.
Chapter/Review
Chen LM and Friedman RM. Somatosensory: Imaging Tactile Perception. In Optical Imaging and Cortical Function (Roe, AW, eds). Elsevier, Oxford, UK. (in press)
Roe AW & Chen LM (2008) High-resolution fMRI maps of cortical activation in non-human primates: correlation with intrinsic signal optical images. ILAR Journal, National Research Council of the National Academies, 49(1): 116-23
Roe, A.W., Chen L.M., and Friedman, R.M., (2007) Intrinsic signal imaging of somatosensory function in non-human primates. The Senses: A comprehensive Reference, Vol 6: Somatosensation (Eds. Allan Basbaum et al). Elsevier, Oxford, UK. (ISBN: 9780126394825)
Chen LM. (2007) Imaging of Pain. Int Anesthesiol Clin. 45(2): 39-57
Roe AW, Friedman RM, Chen LM (2006) Multiple Representation in Primate SI: A View From A Window on the Brain. In Handbook of Neurochemistry and Molecular Neurobiology: Sensory Neurochemistry, Vol 26 (Johnson D, Lajtha A, eds). Springer, New York, NY. pp. 1-16.
Conference Presentations (Selected)
Chen, L.M., Gatenby, J.C., Stringer, E.A., Friedman, R.M., Wang, F., Gore, J.C. and M.J. Avison 2008. High-resolution fMRI of heat pain perception at 7T in humans. 14th Annual Meeting of OHBM (Organization for Human Brain Mapping).
Chen, L.M., Stringer, E.A., Friedman, R.M., Gatenby, J.C., Wang, F., Gore, J.C. and M.J. Avison 2008. High resolution fMRI of heat pain perception in insula and thalamus at 7T in humans. 12th World Congress on Pain (IASP).
Stringer, E.A., Friedman, R.M., Gatenby, J.C., Wang, F., Avison, M.J., Chen, L.M. and J.C. Gore 2008. Heat pain and touch representation within human SII and insula revealed by high resolution fMRI at 7T. 12th World Congress on Pain (IASP).
Stringer, E.A., Friedman, R.M., Gatenby, J.C., Wang, F., Gore, J.C., Avison, M.J. and L.M. Chen 2008. Distinct presentations of heat pain and touch in SI, SII and insula in humans revealed by high resolution fMRI at 7T. 14th Annual Meeting of OHBM (Organization for Human Brain Mapping).
Wang, F., Chen, L.M., Friedman, R.M., Stringer, E.A., Gore, J.C., Avison, M.J. and J.C. Gatenby 2008. High resolution fMRI mapping of the primary somatosensory cortex and thalamus in humans at 7T. 14th Annual Meeting of OHBM (Organization for Human Brain Mapping).
Zhang, N., Chen, L.M., Turner, G.H., Friedman, R., Roe, A.W., Gore, J.C. and M.J. Avison 2008. Using fMRI to explore secondary somatosensory areas in the lateral sulcus of squirrel monkeys.16th Scientific Meeting of ISMRM (International Society for Magnetic Resonance in Medicine).
Zhang, N., Chen, L.M., Gore, J.C., Avison, M.J. (2007) Differential Dependence of BOLD Signal Change to Varying Tactile Stimulus Intensity in Areas 3b and 1 in Anesthetized Squirrel Monkeys. Soc Neurosci. Abstr.
Markus, T., Zhang, N., Gore, J.C., Avison, M.J., Chen, L.M. (2007) Stability of fine fingerpad topography over time in squirrel monkey area 3b revealed by high field fMRI at 9.4T.Soc Neurosci. Abstr.
Gore, J.C., Stringer, E.A., Gatenby, J.C., Friedman, R.M., Avison, M.J., Chen, L.M. (2007) Fine Digit Topography In Human Somatosensory Areas Revealed By High Field (7T) FMRI. Soc Neurosci. Abstr.
Chen, LM., Zhang, N., Gore, J.C., Avison, M.J. (2007) Fine-Scale Negative BOLD Responses Revealed by High Filed fMRI at 9.4T During Tactile Stimulation of Digits in Anesthetized Squirrel Monkeys. Soc Neurosci. Abstr.
Chen LM, Turner GH, Markus T M, Friedman RM, Gore JC, Avison MJ, Roe AW (2006). Fine fingerpad topography in squirrel monkey SII cortex revealed by high field fMRI. Soc. Neurosci Abstr 212.2
Friedman RM, Chen LM, Winberry JE, Roe AW. (2006). Intrinsic and voltage dye imaging of digit activation in somatosensory area 1 of the macaque monkey. Soc. Neurosci Abstr.
Turner GH, Chen LM, Friedman RM, Gore JC, Roe AW and Avison MJ (2006) High spatial resolution fMRI of digit topography and the funneling illusion in SI cortex of the anesthetized squirrel monkey. ISMRM
Chen LM, Friedman RM, and Roe AW. (2004) Optical imaging reveals area-specific activation to thermal nociceptive stimuli in SI of the squirrel monkey. Soc. Neurosci Abstr. 30:374.5.
Ebner, FF, Friedman RM, Chen LM, and Roe AW. (2004) Optical imaging reveals unilateral whisker deprivation modulates rat barrel cortex bilaterally. Soc. Neurosci Abstr. 30:977.17
Friedman RM, Chen LM, and Roe AW. (2004) Optical imaging reveals distinct activation patterns to tactile orientation in SI. Soc. Neurosci Abstr. 30:643.10.
Chen LM, Friedman RM, and Roe AW. (2002) Optical imaging reveals area-specific interactions between nociceptive and tactile responses in SI of squirrel monkey. Soc. Neurosci Abstr. 28:114.12.
Friedman RM, Chen LM, and Roe AW. (2002) Cortical encoding of the tactile funneling illusion: evdience from intrinsic optical imaging. Soc. Neurosci Abstr. 28:841.2.
Roe AW, Healy, FL, Friedman RM, Heider B, and Chen LM. (2002) Differences in SI topography between anesthetized and awake squirrel monkey as revealed by optical imaging. Soc. Neurosci Abstr. 28:651.3.
Chen LM, Friedman RM, Ramsden BM, LaMotte RH and Roe AW. (2001) Fine-scale functional organization of Areas 3b and 1 revealed with intrinsic optical imaging in the squirrel monkey. Chin J Neurosci 17 (sup): p80.
Chen LM, Friedman RM, LaMotte RH, and Roe AW. (2001) Optical imaging of tactile information in area 1 of the squirrel monkey. Soc. Neurosci Abstr, 48.6.
Chen LM, Friedman RM, LaMotte RH, and Roe AW. (2000) Optical imaging of tactile fingerpad sensation in the primary somatosensory cortex of squirrel monkey. Soc. Neurosci Abstr. 26:p1466.
Chen LM, Friedman RM, Ransden BM, Hung CP, LaMotte RH, and Roe AW. (1999) Organization of the somatosensory cortex revealed with intrinsic optical imaging in the squirrel monkey. Soc Neurosci Abstr, 25:p167.
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Li min Chen Ph.D., M.D. 陈立敏助理教授