蒋兴宇研究员

国家纳米科学中心

北京市中关村北一街2号 100080

信箱：xingyujiang@nanoctr.cn

蒋兴宇于1999年在美国芝加哥大学取得化学学士，于2004获得美国哈佛大学化学博士学位。其后在哈佛大学从事博士后研究。在哈佛期间师从George Whitesides。2005年开始在国家纳米科学中心工作，被聘为研究员、博士生导师，入选中科院“百人计划”。研究工作包括：1) 用有机化学、高分子材料、表面化学、和微纳米结构等技术控制蛋白质和细胞与固体表面的相互作用；并用这些技术来研究细胞在固体表面粘附、单个细胞在表面分化和移动的一些基本问题。最近还进行了模式组织的研究工作，构建体外的多种细胞的培养体系。2) 用微流控进行高通量的药物检测、高效的疾病诊断（如人类免疫缺陷病毒和癌症的早期诊断）等以生化传感为中心的应用领域。3) 非常规的方法制备微纳米结构及其生化应用。4)纳米颗粒在生化检测的应用。

最近几年发表论文20多篇，共被引用900多次，并有多项专利申请。

代表性文章1-16

1. Topographical micropatterning of poly(dimethylsiloxane) using laminar flows of liquids in capillaries. Takayama, S., Ostuni, E., Qian, X., Mcdonald, J. C., Jiang, X., Leduc, P., Wu, M.-H., Ingber, D. E., Whitesides, G. M. Adv. Mater. 13, 570-574 (2001).

2. Dynamic, self-assembled aggregates of magnetized, millimeter-sized objects rotating at the liquid-air interface: Macroscopic, two-dimensional classical artificial atoms and molecules. Grzybowski, B. A., Jiang, X., Stone, H. A., Whitesides, G. M. Phys. Rev. E. 64, 011603/1-011603/12 (2001).

3. Soft lithography in biology and biochemistry. Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., Ingber, D. E. Annu. Rev. Biomed. Eng. 3, 335-73 (2001).

4. Gradients of substrate-bound laminin orient axonal specification of neurons. Dertinger, S. K. W., Jiang, X., Li, Z., Murthy, V. N., Whitesides, G. M. Proc. Natl. Acad. Sci. U. S. A. 99, 12542-12547 (2002).

5. Controlling mammalian cell spreading and cytoskeletal arrangement with conveniently fabricated continuous wavy features on poly(dimethylsiloxane). Jiang, X., Takayama, S., Qian, X., Ostuni, E., Wu, H., Bowden, N., Leduc, P., Ingber, D. E., Whitesides, G. M. Langmuir 18, 3273-3280 (2002).

6. Geometric determinants of directional cell motility revealed using microcontact printing. Brock, A., Chang, E., Ho, C.-C., Leduc, P., Jiang, X., Whitesides, G. M., Ingber, D. E. Langmuir 19, 1611-1617 (2003).

7. A miniaturized, parallel, serially diluted immunoassay for analyzing multiple antigens. Jiang, X., Ng, J. M. K., Stroock, A., Dertinger, S. K. W., Whitesides, G. M. J. Am. Chem. Soc. 125, 5294-5295 (2003).

8. Engineering microtools in polymers to study cell biology. Jiang, X., Whitesides, G. M. Eng. Life Sci. 3, 475-480 (2003).

9. Electrochemical desorption of self-assembled monolayers noninvasively releases patterned cells from geometrical confinements. Jiang, X., Ferrigno, R., Mrksich, M., Whitesides, G. M. J. Am. Chem. Soc. 125, 2366-2367 (2003).

10. Rapid prototyping of 2d structures with feature sizes larger than 8 mm. Linder, V., Wu, H., Jiang, X., Whitesides, G. M. Anal. Chem. 75, 2522-2527 (2003).

11. Potentiometric titrations in a poly(dimethylsiloxane)-based microfluidic device. Ferrigno, R., Lee, J. N., Jiang, X., Whitesides, G. M. Anal. Chem. 76, 2273-2280 (2004).

12. Palladium as a substrate for self-assembled monolayers used in biotechnology. Jiang, X., Bruzewicz, D. A., Thant, M. M., Whitesides, G. M., G. M. Anal. Chem. 76, 6116-6121 (2004).

13. Compatibility of mammalian cells on surfaces of poly(dimethylsiloxane). Lee, J. N., Jiang, X., Ryan, D., Whitesides, G. M., Langmuir, 20, 11684-11691 (2004).

14. Self-assembled monolayers in mammalian cell cultures. Jiang, X., Lee, J. N., Whitesides, G. M. in Tissue scaffolding (ed. Ma, P.) (Marcel Dekker, 2005).

15. Directing cell migration with asymmetric micro-patterns. Jiang, X., Bruzewicz, D. A., Wong, A. P., Piel, M., Whitesides, G. M. Proc. Natl. Acad. Sci. U. S. A. 102, 975-978 (2005).

16. Microengineering the environment of mammalian cells in culture. Chen, C. S., Jiang, X., Whitesides, G.M. MRS Bulletin, 30, 194-201 (2005).

17. A general method for patterning gradients of biomolecules on surfaces using microfluidic networks. Jiang, X., Xu, Q., Dertinger, S. K., Stroock, A. D., Fu, T.-M., Whitesides, G. M. Anal. Chem. 77, 2338-2347(2005).

18. Formation of rectangularly shaped Pd/Au bimetallic nanorods: evidence for competing growth of the Pd Shell between the {110} and {100} Side facets of Au nanorods. Xiang, Y., Wu, X., Liu, D., Jiang, X., Chu, W., Li, Z., Ma, Y., Zhou, W., and Xie, S. Nano. Lett. 6, 2290-2294(2006).

19. Micro-scale patterning of cells and their environment. Jiang, X., Takayama, S., Chapman, R. G., Kane, R. S., Whitesides, G. M., in Principles of Tissue Engineering (3rd Ed., ed. Lanzo, R., Langer, R. Vacanti, J.P.), (Academic Press) in press.

20. A method for patterning multiple types of cells using electrochemical desorption of self-assembled monolayers within microfluidic channels. Li, Y., Yuan, Bo., Ji, H., Han, D., Chen, S., Tian, F., Jiang, X., Angew. Chemie. Intl. Ed., 46, 1094-1096 (2007).

21. Geometric Confinement Influences Cellular Mechanical Properties I -- Adhesion Area Dependence. Su, J., Jiang, X., Welsch, R., Whitesides, G.M., So, P., Mol. Cell. Biomech., 4, 87-104 (2007)

22. Geometric Confinement Influences Cellular Mechanical Properties II -- Intracellular Variances in Polarized Cells. Su, J., Brau, R.R., Jiang, X., Whitesides, G.M., Lang, M.J., So, P., Molecular Cellular Biomechanics, Mol. Cell. Biomech., 4, 105-118 (2007)

23. Fabrication of aligned fibrous arrays by magnetic electrospinning. Yang, D., Lu, B., Zhao, Y., Jiang, X. Adv. Mater., 19, 3702-3706 (2007).

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