PHS 398/2590 (Rev. 09/04) Page 1 Biographical Sketch Format Page Principal Investigator/Program Director: Kelleher, Raymond J., III, M.D., Ph.D. BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME Raymond J. Kelleher III, M.D., Ph.D. eRA COMMONS USER NAME RJKELLEHER POSITION TITLE Assistant Professor EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY Massachusetts Institute of Technology B.S. 1986 Biology Massachusetts Institute of Technology B.S. 1986 Literature Stanford University M.D. 1994 Stanford University Ph.D. 1994 Cell Biology American Board of Psychiatry & Neurology Diplomate 1999 Neurology A. Positions and Honors Positions and Employment 1/83-6/86 Research Assistant, Dept. of Biology, Massachusetts Institute of Technology, Laboratory of Prof. Alexander Rich 11/86-6/94 PhD Student, Dept. of Cell Biology, Stanford University School of Medicine, Laboratory of Prof. Roger Kornberg 6/94-6/95 Intern in Medicine, Massachusetts General Hospital, Harvard Medical School 7/95-6/98 Resident in Neurology, Massachusetts General Hospital, Harvard Medical School 7/98-6/99 Clinical and Research Fellow in Neurology, Memory Disorders Unit, Dept. of Neurology, Massachusetts General Hospital, Harvard Medical School 7/98-8/05 Postdoctoral Affiliate, Picower Institute for Learning and Memory, Dept. of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Laboratory of Prof. Susumu Tonegawa 7/99-8/05 Instructor in Neurology, Harvard Medical School 7/99- Assistant Neurologist, Massachusetts General Hospital 9/05- Assistant Professor in Neurology, Harvard Medical School 9/05- Faculty Member, Center for Human Genetic Research and Harvard-Partners Center for Genetics and Genomics, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School Honors 1985 John L. Asinari Award for Outstanding Undergraduate Research in the Life Sciences 1985 I. Austin Kelly III Prize for Excellence in Humanistic Scholarship 1985 Rhodes Scholarship Finalist 1986 Sigma Xi Scientific Research Society, MIT Chapter 1986-1994 Medical Scientist Training Program Predoctoral Fellowship 1998-2003 NIH Mentored Clinical Scientist Development Award 2004-2009 NIH Independent Scientist Development Award 2006-2010 Pew Scholar Award in the Biomedical Sciences 2007-2011 John Merck Scholar Award in the Biology of Developmental Disabilities in Children Professional Memberships 2001 Society for Neuroscience Principal Investigator/Program Director (Last, First, Middle): Kelleher, Raymond J., III, M.D., Ph.D. PHS 398/2590 (Rev. 09/04) Page 2 Continuation Format Page B. Publications Ellison, M.J., Kelleher, R.J., III, and Rich, A. (1985) Thermal regulation of β-galactosidase synthesis using anti-sense RNA directed against the coding portion of the mRNA. J. Biol. Chem. 260: 9085-9087. Ellison, M.J., Kelleher, R.J., III, Wang, A.H., Habener, J.F., and Rich, A. (1985) Sequence-dependent energetics of the B-Z transition in supercoiled DNA containing nonalternating purine-pyrimidine sequences. Proc. Natl. Acad. Sci. USA 82: 8320-8324. Ellison, M.J., Feigon, J., Kelleher, R.J., III, Wang, A.H., Habener, J.F., and Rich, A. (1986) Assessment of the Z-DNA-forming potential of alternating dA-dT stretches in supercoiled plasmids. Biochemistry 25: 3648-3655. Kelleher, R.J., III, Ellison, M.J., Ho, P.S., and Rich, A. (1986) Competitive behavior of multiple, discrete B-Z transitions in supercoiled DNA. Proc. Natl. Acad. Sci. USA 83: 6342-6346. Flanagan, P.M., Kelleher, R.J., III, Feaver, W.J., Lue, N.F., LaPointe, J.W., and Kornberg, R.D. (1990) Resolution of factors required for the initiation of transcription by yeast RNA polymerase II. J. Biol. Chem. 265: 11105-11107. Kornberg, R.D., Buchman, A.R., Chasman, D.I., Darst, S.A., Edwards, A.M., Flanagan, P.M., Kelleher, R.J., Lorch, Y., Lue, N.F., and Sugimoto, K. (1990) Gene activation and transcription in a soluble system from yeast. In Developmental Biology, E.H. Davidson, J.V. Rudeman, J.W. Posakony, editors. Wiley-Liss, Inc. (New York, New York), pp. 307-37. Lue, N.F., Flanagan, P.M., Kelleher, R.J., III, Edwards, A.M., and Kornberg, R.D. (1990) RNA polymerase II transcription in vitro. Methods in Enzymology 194: 545-550. Kelleher, R.J., III, Flanagan, P.M., and Kornberg, R.D. (1990) A novel mediator between activator proteins and the RNA polymerase II transcription apparatus. Cell 61, 1209-1215. Flanagan, P.M., Kelleher, R.J., III, Sayre, M.H., Tschochner, H., and Kornberg, R.D. (1991) A mediator of activation of RNA polymerase II transcription in vitro. Nature 350:436-438. Kelleher, R.J., III, Flanagan, P.M., Chasman, D.I., Ponticelli, A.S., Struhl, K. and Kornberg, R.D. (1992) Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro. Genes & Dev. 6: 296-303. Kornberg, R.D., Chasman, D.I., Darst, S.A., Edwards, A.M., Feaver, W.J., Flanagan, P.M., Gileadi, O., Henry, N.L., Kelleher, R.J., III, Li, Y., Lorch, Y., Sayre, M.H., and Tschochner, H. (1992) Yeast RNA polymerase II transcription in vitro: General initiation factors; novel mediator of transcriptional activation; three dimensional structure of RNA polymerase II. In Transcriptional Regulation, Cold Spring Harbor Press, pp. 349-362. Flanagan, P.M., Kelleher, R.J., III, Tschochner, H., Sayre, M.H., and Kornberg, R.D. (1992) Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation. Proc. Natl. Acad. Sci. USA 89: 7659-7663. Kim, T.K., Hashimoto, S., Kelleher, R.J., III, Flanagan, P.M., Kornberg, R.D., Horikoshi, M. and Roeder, R.G. (1994) Effects of activation-defective TBP mutants on transcription initiation in yeast. Nature 369: 252-255. Kelleher, R.J., III, Govindarajan, A., Jung, H.-Y., Kang, H. and Tonegawa, S. (2004) Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 216: 467-479. Saura, C.A., Choi, S.Y., Beglopoulos, V., Malkani, S., Zhang, D., Rao, B.S.S, Chattarji, S., Kelleher, R.J., III, Kandel, E.R., Duff. K., Kirkwood, A. and Shen, J. (2004) Loss of Presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42:23-36. Kelleher, R.J. III and Tonegawa, S. (2004) Translational regulatory mechanisms in long-term synaptic plasticity and memory. Neuron 44: 59-73. Govindarajan, A., Kelleher, R.J., III and Tonegawa, S. (2006) A clustered plasticity model for storage and reactivation of long-term memory engrams (Perspective). Nat. Rev. Neurosci. 7:575-583. Shen, J. and Kelleher, R.J. III (2006) The Presenilin Hypothesis of Alzheimer’s Disease: Evidence for a loss-of-function pathogenic mechanism. Proc. Natl. Acad, Sci. USA 104: 403-409. Kelleher, R.J. III and Bear, M.F. (2008) The autistic neuron. Cell, in press. Principal Investigator/Program Director (Last, First, Middle): Kelleher, Raymond J., III, M.D., Ph.D. PHS 398/2590 (Rev. 09/04) Page 3 Continuation Format Page C. Research Support ACTIVE 1R01MH080430-01 (Kelleher) 4/1/2007 - 3/31/2112 2.4 calendar NIH/NIMH $237,500 MicroRNAs in Synaptic Plasticity and Cognitive Function The goals of this pending application are to evaluate the function of microRNAs in the adult brain. We employ a conditional genetic approach in mice combined with studies in cultured cortical neurons to examine the roles of microRNAs in neuronal activity-dependent protein synthesis, synaptic plasticity and memory consolidation. K02 NS48274 (Kelleher) 12/15/2004 - 11/30/2009 6.0 calendar NIH/NINDS $159,650 Translational Control in Long-Term Synaptic Plasticity and Memory This independent scientist career development award supports the PI’s program to investigate the molecular mechanisms of neuronal activity-dependent protein synthesis, and to define the contributions of activity-dependent translational control to long-term depression and structural plasticity. Pew Scholars Award (Kelleher) 7/1/2006 - 6/30/2010 0.5 calendar Pew Scholars Program in the Biomedical Sciences $60,000 This scholar award provides support for the PI as a junior faculty member establishing an independent laboratory. The supported research program focuses on investigations of the molecular and cellular mechanisms regulating protein synthesis-dependent synaptic plasticity and memory. IIRG-06-26615 (Kelleher) 9/1/2006 - 8/31/2008 1.0 calendar Alzheimer’s Association $120,000 A Knock-In Mouse Model of Presenilin-Linked Frontotemporal Dementia The goals of this award are to investigate the mechanism by which presenilin mutations cause neurodegeneration and dementia through the generation and analysis of knock-in mice bearing a recently identified presenilin-1 mutation linked to familial frontotemporal dementia. John Merck Scholars Award (Kelleher) 7/1/2007 – 6/30/2011 0.75 calendar John Merck Scholars Program $75,000 This scholar award provides support for the PI as a junior faculty member establishing an independent laboratory. The supported research program focuses on the role of neuronal activity-induced protein synthesis in cognitive function and cognitive disorders. Autism Speaks Pilot Grant (Kelleher) 1/1/2008-12/31/2010 0.5 calendar Autism Speaks $60,000 An Adult Brain-Specific Mouse Model of Neuronal TSC Inactivation The goal of this pilot grant is to develop a unique mouse model for tuberous sclerosis complex, which will allow examination of the intrinsic neuronal functions of TSC1/2 in synaptic plasticity and cognition. OVERLAP: None. COMPLETED K08 NS02071 (Kelleher) 9/1/98 – 7/31/04 6.5 calendar NIH/NINDS $159,650 The Roles of MAP Kinases ERK1/2 in Synaptic Plasticity in the Mammalian Brain The goals of this mentored clinical scientist career development award were to define the contributions of MAPK (ERK1/2) to synaptic plasticity, learning and memory through the generation and analysis of conditional mutant mice, and to characterize the mechanisms by which MAPK regulates these processes. (责任编辑:泉水) |