C. Research Support
ONGOING R01 NS41783 Shen (PI) 05/15/2001-01/31/2011 NIH/NINDS Presenilins in Synaptic Plasticity and Neurodegeneration The goal of the project is to determine the role of presenilins in pre- and post- synaptic plasticity using forebrain-, hippocampal CA1- and CA3- restricted presenilin double conditional knockout mice. Role: PI
R01 NS41779 Shen (PI) 05/15/2001-05/31/2010 NIH/NINDS PINK1 and Recessive Parkinsonism The goal of this project is to determine whether lack of PINK1 causes dopaminergic defects and mitochondrial dysfunction, and to determine whether mice lacking PINK1, parkin and DJ-1 have accelerated dysfunction and degeneration of DA neurons. Role: PI
R01 NS052745 Shen (PI) 09/01/2005-06/30/2010 NIH/NINDS DJ-1 in Dopaminergic Neuronal Function and Survival The goal of this project is to determine whether loss-of-function mutations in the DJ-1 gene alter the normal physiology of dopaminergic neurons in the substantia nigra, ultimately leading to their degeneration and production of parkinsonian phenotypes. Role: PI
R01 NS-42818 Shen (PI) 12/15/01-1/30/08 (no cost extension) NIH/NINDS PS1 and PS2 in Cortical Development and Notch Signaling The goal of the project is to determine the role of PS1 and PS2 in neurogenesis, gliogenesis, neuronal differentiation and migration as well as the regulation of the Notch signaling pathway during neural development. Role: PI
P50 NS38375 Lansbury (Program Director) 08/01/2000-08/31/2010 NIH/NINDS Morris K. Udall Parkinson’s Disease Research Center of Excellence Project 3: Development of Mouse Models of Parkinson’s Disease Shen (PI) The goal of this project is to study the molecular pathogenesis of Parkinson’s disease through the generation and analysis of LRRK2 knockout and conditional knockout mice. Role: PI
Investigator Initiated Research Grant Shen (PI) 12/01/07-11/30/10 Alzheimer's Association Mechanisms of Neurodegeneration Caused by Loss of Presenilin Function The goal of this project is to investigate the cellular and molecular mechanisms by which loss of PS function causes age-dependent neurodegeneration in the adult mouse cerebral cortex. Role: PI
Development of Progressive Mammalian Models of PD Shen (PI) 06/15/2006-06/14/2008 Michael J. Fox Foundation LRRK2 and PD Genetic Mouse Models The goal of this project is to generate and characterize LRRK2 transgenic and knockin mice for PD-like phenotypes.
Fidelity Foundation Shen (PI) 11/1/06-04/30/08 Generation of Presenilin-1 Knockin Mice for Frontotemporal Dementia The goal of this project is to introduce the G183V mutation into the presenilin-1 locus and to analyze the knockin mouse for deficits in memory and synaptic plasticity and for neurodegeneration.
Fidelity Foundation Shen (PI) 12/1/07-07/31/08 Presenilins, Gamma-Secretase and Notch in Neuronal Death The goal of the project is to determine the role of Notch receptors in memory, synaptic plasticity and neuronal survival in the adult cerebral cortex, and to investigate whether the essential roles of PS are mediated in a gamma-secretase-dependent or independent manner through comparative analysis of nicastrin cKO and PS cDKO mice. PENDING R01 NS42818 Shen (PI) competing continuation 08/01/2008 – 07/31/2013 NIH Presenilins, Gamma-Secretase and Notch in Neuronal Death The goal of the project is to determine the role of Notch receptors in memory, synaptic plasticity and neuronal survival in the adult cerebral cortex, and to investigate whether the essential roles of PS are mediated in a gamma-secretase-dependent or independent manner through comparative analysis of nicastrin cKO and PS cDKO mice. (The application was scored at 0.3th percentile)
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