Hongbo Yu博士(2)

During the above two photon mapping experiments, surprisingly we found that astrocytes, the “silent” cells (their number is similar or even greater to neurons in cortex), were responsive to visual stimuli, their calcium responses were highly feature selective, and their feature mapping was as precise as that of neurons. We further proved that the above unique behaviour of astrocytes served as the basis of precise neuron-astrocyte-vascular coupling in the functional columns (Science, second round revision).

Other related projects. Our technical and scientific progresses propel the functional studies in Sur lab. I participated in the following projects: multiple feature mapping in monocularly enucleated ferrets( J. Neurosci., 2007); functional screening of multiple genetically modulated mice by intrinsic optical imaging (Nature Neurosci., 2006); in vivo imaging of CaMKII activity in the primary visual cortex of ferrets using FRET; two photon calcium imaging in multiple gene knock out mice; orientation selectivity of inhibitory neurons in the primary visual cortex by two photon imaging; the influence of feedback pathways in the primary visual cortex by two photon imaging.

Manuscripts in preparation:

H. Yu, A. Majewska, M. Sur. Rearrangement of dendritic spines during short-term monocular

deprivation in the primary visual cortex of the ferret in vivo. (Nature, in preparation).

H. Yu, J. Schummers, M. Sur. The precise relationship between visual space, orientation and spatial

frequency maps at single cell resolution. (Nature, in preparation).

Abstracts

Y. Zhou, H. Yu, Y. Yang, Z. Zhou and T. Shou. Postsynaptic potential properties of relay cells to the non-dominant eye in the LGNd cells of the cat. Biophysics Journal 74(2), pt (2): A87, 1998.

T. Shou, W. Wang and H. Yu. Orientation-biased extended surround beyond the classical receptive field center may help the retina detect texture segmentation. Soc. Neurosci. Abstr. 25, 424(10): 1042, 1999.

H. Yu, B.J. Farley, J. Sharma and M. Sur. Relationship between multiple stimulus feature maps in ferret visual cortex. Soc. Neurosci. Abstr. 27, 2001.

H. Yu, B.J. Farley, M. Sur. Spatial relationships between retinotopy and four other feature maps in ferret visual cortex. Soc. Neurosci. Abstr. 28, 2002.

J.R. Newton, J. Sharma, H. Yu and M. Sur. Optical imaging of intrinsic signals reveals visual organization in mouse V1 and V2. Soc. Neurosci. Abstr. 29, 2003.

J.R. Newton, J. Sharma, H. Yu and M. Sur. Intrinsic signal optical imaging reveals the distinct effects of thalamic and cortical mechanisms on patterning and arealization in V1 and V2 of ephrin A2/A5 knock-out mice. Soc. Neurosci. Abstr. 30, 2004

H. Yu, A. Majewska, M. Sur. Structural correlates of rapid ocular dominance plasticity in the ferret. Soc. Neurosci. Abstr. 30, 2004

H. Yu, A. Majewska, M. Sur. Rearrangement of dendritic spines during short-term monocular deprivation in the primary visual cortex of the ferret in vivo. Soc. Neuroscience Abstr. 31, 2005.

A.F.Mower, S. Kwok, A. Majewska, H. Yu, K. Okamoto, Y. Hayashi, M. Sur.. In vivo imaging of CaMKII activity in the primary visual cortex of ferrets using FRET. Soc. Neuroscience Abstr. 32, 2005.

A.F.Mower, S. Kwok, A. Majewska, H. Yu, K. Okamoto, Y. Hayashi, M. Sur. In vivo FRET imaging reveals eye domain-specific activation of CaMKIIα in ferret visual cortex. Soc. Neuroscience Abstr. 32, 2006.

B.J. Farley, H. Yu, D. Z. Jin, M. Sur. Experimental effects of removing the ocular dominance map on the organization of the remaining feature maps in visual cortex. Soc. Neuroscience Abstr. 32, 2006.

J. Schummers, H. Yu, M. Sur. Single-cell resolution mapping of multiple stimulus features in ferret visual cortex with two-photon calcium imaging. Soc. Neuroscience Abstr. 32, 2006.

H. Yu, J. Schummers, M. Sur. Orientation tuning of visually evoked increases in calcium concentration in astrocytes in visual cortex of the ferret. Soc. Neuroscience Abstr. 32, 2006.

H. Yu, J. Schummers, M. Sur. The relationship between multiple feature maps in ferret visual cortex at single cell resolution. Soc. Neuroscience Abstr. 33, 2007.

J. Schummers, H. Yu, M. Sur. Role of astrocytes in translating neuronal activity to hemodynamic responses in visual cortex. Soc. Neuroscience Abstr. 33, 2007.

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Hongbo Yu博士(2)