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宿兵--复旦大学生命科学院

时间:2004-05-09 16:01来源:本站原创 作者:admin 阅读:
Curriculum Vitae

Name: Bing Su, PhD

Education and Research Experiences

1985.9-1989.7: B.A., Major: Cell Biology, Biology Department, Wuhan University.
1991.9-1996.7: Ph. D., Kunming Institute of Zoology, the Chinese Academy of
Sciences.
1994.8-1995.2: Visiting student, University of California, San Diego
1996.8-1997.8: Research Associate, Kunming Institute of Zoology
1997.9-2000.2: Postdoctor, Human Genetics Center, University of Texas
2000.3-2001.5: Research Fellow, Human Genetics Center, University of Texas
2001.5- present: Assistant Professor, Center for Genome Information, University of Cincinnati, USA.
2001.5- present: Director and Professor, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, China
2001.9- present: Visiting Professor, College of Life Science, Fudan University, China.

Honors and Awards

1996 The award of natural science research of the Chinese Academy of Sciences
1997 The national award of natural science research of China
2002 The award of natural science research of Yunnan province of
China
2003 The award of natural science research of ministry of education, China

Research Interest
With the completion of human genome sequencing project, scientists are now facing the challenge of understanding the three billion genetic codes in the human genome, i.e. to establish the connections between genetic make-up and their functional consequences. By conducting genome wide comparative genetic analysis among living primates including humans, we aim to understand the genetic mechanism of human origin by answering the following questions:
1. How does genome structure change during primate evolution?
2. How do new genes carrying new functions emerge during primate evolution?
3. What are the genes involved in the progressive changes of cognitive skills during primate evolution, especially during human origin?


On-going Projects

1. Comparative brain gene expression analysis in humans and nonhuman primates.
The genetic mechanism of human cognitive skills is an essential and long-standing question. It is widely believed that the prefrontal cortex (PFC) is the region of the primate brain responsible for several complex cognitive skills, such as working memory, behavior inhibition, language, and the regulation of emotion and social behavior. With the use of microarray and comparative sequencing tools, we aim to compare gene expression profiles of three functionally well documented PFC sub-regions (the dorsolateral PFC, the inferior convexity, and the orbital frontal cortex) between humans and nonhuman primates. The human oligo chips covering nearly 17,000 human genes will be used to measure interspecies expression differences in order to identify genes showing differential expression between human and nonhuman primates, and hence potentially responsible for the marked PFC functional differences between them. The results from this project will generate new and exciting data regarding the genetic basis of human brain function and will eventually benefit clinical applications in treating human mental disorders.

2. Molecular evolution of fast-evolving genes expressed in the brain and the genetic mechanism of human origin

To identify genetic features that underlie unique human biological traits is the key to understand human origin. The enlarged brain and sophisticated cognitive skills (e.g. language) is one of the most significant adaptive changes during human evolution. The genetic basis for these adaptive changes remains unclear. Genes expressed in the human brain are likely the targets of Darwinian positive selection that result in adaptive functional changes during human evolution. Hence, comparative sequence analysis of rapid-evolving genes expressed in the brain between humans and nonhuman primates is informative in identifying the genetic modifications contributing to human brain functions, and delineating the genetic mechanism of human evolution. Based on a genome-wide screen and sequence comparison of 7,430 brain-expressed genes, 51 candidate genes were identified showing rapid amino acid changes between human and chimpanzee. These candidate genes are involved in varied biological processes, including neurogenesis and transcription regulation, therefore, potentially responsible for the origin of human intelligence. With the use of DNA sequencing technology and analytic tools in molecular evolution and population genetics, we are sequencing the coding regions of the 51 candidate genes and compare them among humans and representative nonhuman primate species in order to identify genes undergone adaptive evolution in the human lineage, to detect human-specific sequence variations that are potentially involved in brain development and functional changes during human evolution.


Publications

1. Wang YQ, Su B. 2004 Molecular evolution of microcephalin, a gene determining human brain size. Human Molecular Genetics (in press)
2. Qian, YP, Jin L, Su B. 2004 Construction and characterization of bacterial artificial chromosome library of black-handed spider monkey (Ateles geoffroyi) Genome 47:239-245.
3. Xu HL., Qian YP., Nie WH., Chi JX., Yang FT., Su B. 2004 Construction, characterization and chromosomal mapping of bacterial artificial chromosome (BAC) library of Yunnan snub-nosed monkey (Rhinopithecus bieti). Chromosome Research 12:251-262.
4. Lell, JT., Sukernik, RI., Starikovskaya, YB., Su B. et al. 2002 The dual origin and Siberian affinities of Native American Y chromosomes. American Journal of Human Genetics 70:192-206.
5. Wells RS, Yuldasheva NY, Ruzibakiev RM, Underhill PA, Evseeva I, Blue-Smith J, Jin L, Su, B. et al. 2001 The Eurasian heartland:A continental perspective on Y-chromosome diversity. PNAS 98:10244-10249.
6. Ramana GV, Vasanthi A, Khaja M, Su B et al. 2001 Distribution of HIV-I resistance-conferring polymorphic alleles SDF-1-3’A, CCR2-64I and CCR5-32 in diverse populations of Andhra Pradesh, South India. J. of Genet. 80:137-140
7. Ke YH, Su B.(co-first author) et al. 2001 No independent origin of modern humans in East Asia: a tale of 12,000 Y chromosomes. Science 292:1151-1153.
8. Ramana GV, Su B et al. 2001 Y chromosome SNP haplotypes suggest evidence of gene flow among caste, tribe, and the migrant Siddi populations of Andhra Pradesh, South India. Eur. J. Hum Genet. 9:695-700
9. Su, B et al. 2001 Genetic diversity and population history in Red Panda (Ailurus fulgens) as inferred from mitochondrial DNA sequence variations. Molecular Biology and Evolution 18:1070-1076.
10. Akey, J.M.;Sosnoski, D.;Parra, E.;Dios, S.;Hiester, K.;Su, B. et al. 2001
Melting Curve Analysis of SNPs (McSNP): A Gel-Free and Inexpensive Approach for SNP Genotyping. BioTechniques 30:358-367
11. Ke, YH., Su, B et al. 2001 Y-chromosome haplotype distribution in Han Chinese populatiions and modern human origin in East Asians. Science in China (Series C) 44:225-232.
12. Ke, YH., Su, B et al. 2001 Y-chromosome evidence for no independent origin of modern human in China. Chinese Science Bulletin 46:935-937.
13. Su, B et al. 2000 Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Human Genetics 107:582-590
14. Su, B et al. 2000 Distributions of three HIV-1 resistant polymorphisms (SDF1-3'A, CCR2-64I, and CCR5-32) in Global Populations. European Journal of Human Genetics 8:939-945
15. Su, B et al. 2000 Polynesian Origins: New Insights from the Y-chromosome PNAS, USA 97:8225-8228
16. Jin L and Su B. 2000 Natives or Immgrants: Modern human origin in East Asia. Nature Reviews Genetics 1:126-133.
17. Qian YP, Qian BZ, Su B. 2000 Multiple Origins of Tibetan: Y Chromosome Evidences. Human Genetics 106:453-454
18. Peterson, B., Su, B et al., 2000 World population data for the HLA-DQA1,PM and D1S80 loci with least and most common profile frequencies for combinations of loci estimated following NRC II guidelines. Journal of Forensic Science. 45 (1):118-146
19. Su, B et al. 1999 Y Chromosome evidence for a Northward Migration of Modern Humans into East Asia during the Last Ice Age. American Journal of Human Genetics 65:1718-1724
20. Su, B et al. 1999 Distribution of two HIV-1 polymorphisms (SDF1-3’A and CCR2-64I) in East Asia and world populations and its implication in AIDS epidemiology. American Journal of Human Genetics 65:1047-1053
21. Su, B et al. 1999 Phylogenetic study of complete cytochrome b genes of musk deer (genus Moschus) using museum samples. Molecular Phylogentics and Evolution 12:241-249
22. Chakraborty, R., Stivers, DN. and Su, B et al., 1999 The utility of short tandem repeat loci beyond human identification: Implications for development of new DNA typing systems. Electrophresis 20:1682-1696
23. Su, B et al. 1998 Frequency of an HIV-resistant allele is exceptionally high in New Guinea Highlanders. Journal of the American Medical Association, JAMA. 280:1830
24. Hu, WP., Lian, LS., Su, B et al 1998 Genetic diversity of Yunnan local pig breeds inferred from blood protein electrophoresis. Biochemical Genetics. 36:207-212.
25. Lan, R., Hong, QH., Gao YH., Zhang J., Su, B. et al. 1998 Mitochondrial DNA polymorphism in sheep from Yunnan. Hereditas. 20(1): 20-23.
26. Su, B. et al. 1997 Genetic diversity and molecular phylogeny of slow lorris (Genus Nycticebus) Primates 39(1): 79-94
27. Su, B. et al. 1997 Protein variation and genetic divergence of Chinese macaques (Genus Macaca) . Chinese Journal of Genetics.
28. Chen, YJ., Wang, W., Su, B. et al. 1997 Genetic divergence of Cordyceps sinensis as estimated by random amplified polymorphic DNA analysis. Chinese Journal of Genetics. 24(5): 410-416.
29. Xiao, WH., Su, B. et al. 1997 A simple method for getting digoxigenin labeling probe of mtDNA form ovary of fish. Zoological Research. 18(1): 72-78.
30. Yu, Y. Wen, JK., Zhu, FX., Zhao, KD., Su, B. et al. 1997 Genetic diversity of Wenshan and Diqing yellow cattle in Yunnan province assayed by protein electrophoresis. Zoological Research. 18(3): 333-339.
31. Su, B. et al. 1996 Molecular phylogeny of Chinese concolor gibbons. Science in China. 26(5): 414-419
32. Su, B., Chen, Z. P., et al. 1996 Protein polymorphism and genetic differentiation in three species of Apodemus from Yunnan. Zoological Research. 17:259-262.
33. Wang, W. Su, B et al., 1996 Interspecific differentiation of the slow lorses (Genus Nycticebus) inferred from ribosomal DNA restriction maps. Zoological Research. 17(1): 89-93.
34. Nie, L., Chen, YJ., Wang, W., Su, B. et al 1996 Mitochondrial DNA polymorphism in Xuwen yellow cattle and Hainan yellow cattle. Zoological Research. 17(3): 269-274.
35. Wang, W., Su, B. et al., 1996 Phylogenetic relationships among six species of Macaca inferred from ribosomal DNA variations. Chinese Journal of Genetics. 23(4): 247-253.
36. Su, B et al. 1995 Genetic diversity in the snub-nosed monkey (Rhinopithecus bieti) as estimated by protein electrophoresis. Conservation Biology 9(4): 847-851.
37. Su, B., Liu, A. H. et al. 1995 Protein polymorphism and genetic differentiation in Yunnan common horse and short horse populations. Zoological Research. 16(2): 126-131
38. Wang W, Su B et al., 1995 Phylogenetic relationship among two species of golden monkey and three species of leaf monkey inferred from ribosomal DNA variation. Folia Primatologica 65:138-143
39. Wang, W., Lan, H., Su, B. et al., 1995 Analysis of randomly amplified polymorphic DNAs for four minorities in Yunnan province. Chinese Science Bulletin. 40(2): 158-163.
40. Su, B et al., 1994 Genetic diversity in Chinese pangolin (Manis pentadactyla) based on protein electrophoresis. Biochemical Genetics 32:343-349.
41. Su, B et al., 1994 Genetic diversity of giant panda: evidence from protein electrophoresis. Chinese Science Bulletin 39(8):742-745
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