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于翔(XIANG YU)博士简介

时间:2004-11-18 17:04来源:本站原创 作者:admin 阅读:
yu xiang

XIANG YU, Ph.D.

Address Nancy Pritzker Laboratory E−mail [email protected]

Dept. Psychiatry and Behavior Sciences Phone (650) 387 2757

1201 Welch Rd, MSLS bldg P104 Fax (650) 498 7761

Stanford University Medical Center

alo Alto, CA 94304−5485 Sex female

P

EDUCATION
1999 Ph.D., Laboratory of Molecular Biology and Trinity College, University of Cambridge, UK.

Thesis title: Wingless signal transduction during Drosophila embryonic development.

1999 M.A. Cantab., Trinity College, University of Cambridge, UK.
1995 B.A. Cantab., Trinity College, University of Cambridge, UK.

Natural Sciences (Biochemistry): First Class Honours.


PROFESSIONAL EXPERIENCE

1999−present Wellcome Trust Fellow and Research Associate with Prof. Robert Malenka.

Nancy Pritzker Laboratory, Dept. Psychiatry, Stanford University, Palo Alto, CA.

The cadherin/catenin complex in dendritic morphogenesis and synaptic function.

1995−1999 Doctoral research with Dr. Mariann Bienz.

MRC Laboratory of Molecular Biology, Cambridge, UK.

Wingless signal transduction during Drosophila embryonic development.

1994−1995 Undergraduate research with Prof. Jean Thomas.

Dept. Biochemistry, University of Cambridge, UK.

The effect of point mutations on the DNA binding properties of histone H5.

summer 1994 Undergraduate research with Dr. Mariann Bienz.

MRC Laboratory of Molecular Biology, Cambridge, UK.

The Wingless signaling pathway in the Drosophila embryonic midgut.


FELLOWSHIPS AND AWARDS

1999−2001 Wellcome International Prize Travelling Research Fellowship, Wellcome Trust, UK.

1999 Full tuition scholarship, Neurobiology course, Marine Biological Laboratory, Woods Hole, MA.

1998−1999 Senior Rouse Ball Studentship, Trinity College, Cambridge, UK.

1998 Grass Foundation scholar, Brain Development and Function Course, Cold Spring Harbor, NY.
1995−1998 Overseas Research Scholarship, British Government.

1995−1998 Research Scholar, Trinity College, Cambridge, UK.

1995−1998 Honorary Scholar, Cambridge University Overseas Trust, UK.

1994−1995 Senior Scholar, Trinity College, Cambridge, UK.

1993−1994 Junior Scholar, Trinity College, Cambridge, UK.


TEACHING EXPERIENCE AND RESPONSIBILITIES

2004 Supervisor – Undergraduate research project

2000−present Administrator − Nancy Pritzker Laboratory Imaging Facility.

2002−2004 Supervisor − tissue culture technician.

1996−1997 Teaching assistantship to second year Natural Sciences undergraduates in:

• Biochemistry • Molecular Biology
• Cell Biology
• Developmental Biology

PUBLICATIONS


1. Goytisolo, F.A., Gerchman, S.E., Yu, X., Rees, C., Graziano, V., Ramakrishnan, V. and Thomas, J.O. (1996).
Identification of 2 DNA−binding sites on the globular domain of histone H5. EMBO J. 15, 3421−3429.

2. Yu, X., Hoppler, S., Eresh, S., and Bienz, M. (1996). decapentaplegic, a target gene of the wingless signaling

pathway in the Drosophila midgut. Development 122, 849−858.

3. Riese, J., Yu, X., Munnerlyn, A., Eresh, S., Hsu, S., Grosschedl, R., and Bienz, M. (1997). LEF−1, a nuclear

factor coordinating signaling inputs from wingless and decapentaplegic. Cell 88, 777−787.

4. Yu, X., Riese, J., Eresh, S., and Bienz, M. (1998). Transcriptional repression due to high levels of Wingless

signalling. EMBO J. 17, 7021−7032.

5. Yu, X. and Bienz, M. (1999). Ubiquitous expression of a Drosophila APC homolog and its localisation in cortical
actin caps. Mech. Dev. 84, 69−73, cover story.

6. Yu, X., Waltzer, L., and Bienz, M. (1999). A new Drosophila APC homolog associated with adhesive zones of

epithelial cells. Nature Cell Biol. 1, 144−151, cover story.

7. Beattie, E., Carroll. R., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., and Malenka, R.C. (2000). Regulation
of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nature Neurosci. 3, 1291−1300.

8. Yu, X. and Malenka, R.C. (2003). βcatenin is critical for dendritic morphogenesis. Nature Neurosci. 6, 1169−
1171, cover story.


9. Yu, X. A Wingless Flight. (2003). PLOS Biology 1, 324-326.
10. Yu, X., and Malenka, R.C. Multiple functions for the cadherin/catenin complex during neuronal development.

Neuropharmacology, 47 (The Cytoskeleton and Synaptic Function Issue), 779−786.


11. Marie, H., Morishita, W., Yu, X., Calakos, N., and Malenka, R.C. Generation of silent synapses by acute in vivo
expression of CaMKIV and CREB. (in revision).


12. Yu, X. and Malenka, R.C. The effect of changes in dendritic morphology mediated by the cadherin/catenin
complex on synapse formation and function. (in preparation).


13. Krichmar, J.L., Yu, X., Velasquez, D., Malenka, R.C., and Ascoli, G.A. Effects of βcatenin on dendritic

morphology and simulated firing patterns in cultured hippocampal neurons. (in preparation).


POSTER PRESENTATIONS
1. Yu, X. and Bienz, M. (1998). Transcriptional repression mediated by Wingless. EMBL−SALK Conference:
Oncogenes and Growth Control, Heidelberg, Germany.

2. Yu, X. and Malenka, R.C. (2001). A role for βcatenin in dendritic morphogenesis. Annual Meeting of the
Society for Neuroscience, San Diego, CA.

3. Yu, X. and Malenka, R.C. (2002). A role for βcatenin in dendritic morphogenesis. Keystone Symposia X1:
Wnt and βcatenin signaling in development and disease, Taos, NM.

4. Krichmar, J.L., Yu, X., Velasquez, D., Malenka, R.C., and Ascoli, G.A. (2003). Effects of βcatenin on dendritic
morphology and simulated firing patterns in cultured hippocampal neurons. Annual Meeting of the Society for

Neuroscience, New Orleans, LA.

5. Yu, X. and Malenka, R.C. (2004). The effect of changes in dendritic morphology mediated by the cadherin/
catenin complex on synapse formation and function. Annual Meeting of the Society for Neuroscience,

San Diego, CA.


6. Yu, X. and Malenka, R.C. (2004). The effect of changes in dendritic morphology mediated by the cadherin/
catenin complex on synapse formation and function. 14th Neuropharmacology Conference: The cytoskeleton and synaptic function, San Diego, CA.

ORAL PRESENTATIONS AND INVITED SEMINARS


Slide presentation (2003). A critical role for βcatenin during dendritic morphogenesis. Annual Meeting of the Society for Neuroscience, New Orleans.


Invited seminars (2004). Dept. Neurobiology and Physiology, Northwestern University; Dept. Cell and Developmental Biology, Vanderbilt University; Dept. Neurobiology, Duke University; Dept. Molecular, Cell and Developmental Biology, UC Santa Cruz; Dept. Neurosciences, Case Western Reserve University; Zilkha Neurogenetic Institute, University of Southern California; Dept. Neuroscience and Physiology, SUNY Upstate Medical University; College of Life Sciences, Peking University, China; Dept. Physiology and Neuroscience, Medical University of South Carolina; Synapses and Cognitive Neuroscience Center, Medical College of Georgia; Children’s Hospital of Philadelphia.


RESEARCH TECHNIQUES

Microscopy Bright−field, phase contrast, differential interference contrast (DIC) and laser scanning confocal microscopy. Quantitative analysis of neuronal morphology and protein subcellular localization using Metamorph software. Time−lapse (GFP and GFP−tagged proteins), FM1−43

and calcium imaging of cultured hippocampal neurons.

Tissue culture Culturing of established cell lines, primary dissociated hippocampal cultures and adult derived stem cell lines. Calcium phosphate and lipofectamine transfection and viral infection of

cultured hippocampal neurons and neural stem cells.

Electrophysiology Standard electrophysiology techniques including whole cell patch clamping of cultured

hippocampal neurons and analysis of miniature EPSCs.

Molecular biology DNA cloning, PCR amplification, mutagenesis and sequencing; cDNA library screen; yeast

two−hybrid screen.

Biochemistry Expression and purification of recombinant proteins from bacteria; affinity and FPLC

chromatography, sucrose gradients, band−shift assays; western and southern blots.

Genetics Standard genetics using mutants and over−expression strains, P−element transformation;

(Drosophila) generation of germline clones; mutagenesis screens using EMS, X−ray and P−element mobilization; in−situ hybridization of polytene chromosomes.



PROFESSIONAL ACTIVITIES
Reviewer, Nature Neuroscience

Member, Society for Neuroscience

Post−doctoral representative and mentor, Mentoring Committee, Palo Alto Chapter of American Women in

Science (AWIS)


COURSES AND WORKSHOPS
Spring 2000 Course: Biological Light Microscopy, Graduate Program, Stanford University, CA.
Summer 1999 Course: Neurobiology, Marine Biological Laboratory, Woods Hole, MA.

Summer 1998 Course: Brain Development and Function, Cold Spring Harbor Laboratory, NY.

Spring 1998 Workshop: Wiring the brain: mechanisms that control the generation of neural specificity,

Juan March Institute, Madrid, Spain.
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