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清华大学医学院干细胞及表观遗传研究室招聘启事

时间:2011-08-08 22:22来源: 作者: 点击: 120次
 
本实验室主要研究表观遗传调控机制在干细胞多能性、动物生长发育和癌变中的作用。拟招聘实验室行政助理、生物信息研究助理和博士后各1 名。待遇参照清华大学标准,提供有竞争力的薪酬(具体视个人情况而定)。
 
课题组研究背景:
 
http://www.tsinghua.edu.cn/publish/med/;
 
选择师资队伍,专任教师,进入沈晓骅教授主页。或者,
 
http://www.tsinghua.edu.cn/publish/med/3157/2010/20101215191338102615411/20101215191338102615411_.html
 
一、科研行政助理:
 
工作职责:
 
1、协助管理实验室的日常运转,包括试剂、耗材和仪器订购及报修,各类文档和数据的管理和备案;
 
2、 处理相关办公室事宜,包括科研经费管理、年度报告和学生工作。
 
3、辅助完成简单的生物学实验 (optional)。
 
资格要求:
 
1、 本科以上学历,年龄不限;具有生物、生物信息、计算机背景者优先;
 
2、 有较好的计算机操作能力、中文写作和打字能力; 较好的英语水平;
 
3、 具有较好的管理能力,善于沟通和交流,具有团队合作精神;
 
4、 具有极强的责任心,工作主动积极,办事利落、细心和周全;
 
5、 能长期稳定工作。
 
二、生物信息研究助理、博士后:
 
工作职责:
 
基因调控网络和表观遗传信息平台的构建;进行 ChIP-seq、RNA-seq、RIP-seq 数据分析;独立或协助其他研究人员完成高通量数据的挖掘。
 
资格要求:
 
生物信息学或理工科背景,硕士以上学历; 具有高通量数据分析经验者优先; 善于沟通和交流,具有团队合作精神,工作主动积极。
 
三、博士后:
 
资格要求:Talented, highly motivated individual with prior experience in related research areas
 
工作职责: Conducting research projects involved in the epigenetic regulation of stem cell pluripotency (detail as below).
 
Stem cells are remarkable cells as they possess ability to self-renew and differentiate. Stem cell differentiation is accompanied by epigenetic changes. As all cells in the body contain the same or very similar set of epigenetic machinery, one intriguing question is how cell specific epigenetic landscapes are established. Toward an overall understanding how chromatin structure in influences gene expression and cell fate specification, the major portion of our research is to elucidate how epigenetic mechanisms are guided by and interact with lineage-specific factors, including proteins and/or non-coding ncRNAs to define cellular states in development and disease. Polycomb group proteins (PcG) mediate epigenetic regulation through trimethylation on histone H3 lysine 27 (H3K27me3). An initial, yet critical step in PcG regulation of gene expression is the targeting of a protein complex named Polycomb repressive complex 2 (PRC2) to specific regions of chromatin to establish the repressive H3K27me3 mark. Despite the essential role for PRC2 and H3K27me3 in execution of stem cell pluripotency and in development, little is known about how PRC2 is regulated and targeted to the chromatin and how the H3K27me3 mark is maintained and reestablished during cell division and fate transition. We use state-of-art, high-throughput and integrative technologies across proteomic and genomic systems, together with mouse genetics, biochemical, molecular, cell biology and imaging tools to investigate the recruitment and regulation of PRC2 in stem and cancer cells. We aim to obtain a comprehensive and dynamic view of how transcription factors, ncRNAs and DNA motifs collaborate in targeting and regulating PRC2 during stem cell differentiation, and how disregulation in the above processes leads to human disease, particularly cancer.
 
四、招聘办法和要求
 
请应聘者将本人简历、研究工作经历,及其它能证明本人工作能力的相关电子文件,两位推荐人的姓名和联系方式,通过电子邮件寄给联系人:xshen@tsinghua.edu.cn。邮件主题请注明应聘岗位的名称。招聘自本通知发布之日起,直至位置填满为止。
 
联系人:清华大学医学院 沈晓骅教授
 
邮箱:xshen@tsinghua.edu.cn
 
通讯地址:北京海淀区清华大学医学科学楼B107,邮编 100084.
 
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