于翔, Ph.D.
邮 箱： yuxiang01 (AT) pku.edu.cn
办公室电话：62757531
所属实验室：于翔实验室
实验室电话：62758685
教育经历:
1995－1999，博士，英国剑桥大学、MRC分子生物学实验室 （细胞生物学）1992－1995，学士，英国剑桥大学、三一学院 （自然科学）
工作经历:
2019－至今，教授，北京大学生命科学学院2019－至今，研究员，北京大学-清华大学生命科学联合中心
2019－至今，研究员，北京大学麦戈文脑科学研究所
2019－至今，主任，北京大学医学部孤独症研究中心
2005－2019，研究员，中国科学院神经科学研究所
1999－2005，博士后，美国斯坦福大学医学中心
荣誉奖励:
2022, “长江学者奖励计划”特聘教授2020，北脑学者
2019，张香桐神经科学青年科学家奖
2018，“万人计划”科技创新领军人才
2017，中国科学院优秀研究生指导教师
2017，上海领军人才
2016，上海市优秀学术带头人
2016，中青年科技创新领军人才
2014，第七届上海青年科技英才（基础研究类）
2014，第十一届中国青年女科学家奖
2012，中国科学院优秀研究生指导教师
2011，国家杰出青年科学基金
2005，中国科学院百人计划
2005，Grass Fellow, Marine Biological Laboratory, Woods Hole, MA.
1999，Wellcome Prize Travelling Research Fellowship
学术任职:
2024 - 今 中国实验动物学会副理事长2024－今 美国神经科学学会全球会员委员会委员
2022－今 北京市实验动物专家委员会副主任委员
2022－今 国际孤独症研究学会（INSAR）科学标注委员会成员
2022－2023 国际脑研究组织（IBRO）日程委员会成员
2021－今 北京神经科学学会第十届监事会成员
2021－2023 美国神经科学学会 (SfN) Peter Seeburg 综合神经科学奖评委会委员
2020－今 中国神经科学学会儿童认知与脑功能障碍分会副主任委员
2020－今 中国神经科学学会神经发育与再生分会委员
2019－2023 美国神经科学学会 (SfN) 日程委员会成员
杂志任职:
2023 - 今 Neuron，编委2022 - 今 《中国科学：生命科学》，编委
2022 - 今 National Science Review ，生命学科编辑工作组
2021 - 今 eLife，编委
2020 - 今 Autism Research，编委
2019 - 今 Journal of Cell Biology，编委
2017 - 今 Developmental Neurobiology，编委
代表性论文:
1. Li H., Jiang T., An S., Xu M., Gou L., Ren B., Shi X., Wang X., Yan J., Yuan J., Xu X., Wu Q.F., Luo Q., Gong H., Bian W.J.* Li A.*, Yu X.* (2024) Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns. Neuron 112(7):1081-1099.
2. Duan L.* and Yu X.* (2024) Fibroblasts: New players in the central nervous system? Fundam. Res. 4(2):262-266.
3. Wang M.* and Yu X.* (2023) Experience-dependent structural plasticity of pyramidal neurons in the developing sensory cortices. Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2023.102724
4. Li G.Y.*, Wu Q.Z., Song T.J., Zhen X.C., Yu X.* (2023) Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain. Acta Pharmacol. Sin. 44(6):1109–1121.
5. Yu H., Miao W., Ji E., Huang S., Jin S., Zhu X., Liu M.Z., Sun Y.G., Xu F., and Yu X.* (2022) Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions. Neuron 110(6):1051-1067. (highlighted by same issue Preview 110(6):909-911)
6. Yu X.* (2021) Q&A Xiang Yu. Neuron 109(19):3022-3024.
7. Cao H., Li M.Y., Li G., Li S.J., Wen B., Lu Y., and Yu X.* (2020) Retinoid X receptor α regulates DHA-dependent spinogenesis and functional synapse formation in vivo. Cell Rep. 31(7):107649.
8. Wang M., Yu Z., Li G., and Yu X.* (2020) Multiple morphological factors underlie experience-dependent cross-modal plasticity in the developing sensory cortices. Cereb. Cortex, 30(4):2418–2433.
9. Duan L., Zhang X.D., Miao W.Y., Sun Y.J., Xiong G., Wu Q., Li G., Yang P., Yu H., Li H., Wang Y., Zhang M., Hu L.Y., Tong X., Zhou W.H., Yu X.* (2018) PDGFRβ cells rapidly relay inflammatory signal from the circulatory system to neurons via chemokine CCL2. Neuron 100(1):183-200. (highlighted by same issue Preview 100(1):11-13)
10. Hu C.C., Xu X.*, Xiong G.L., Xu Q., Zhou B.R., Li C.Y., Qin Q., Liu C.X., Li H.P., Sun Y.J.*, Yu X.* (2018) Alterations in plasma cytokine levels in Chinese children with autism spectrum disorder. Autism Res. 11(7):989-999.
11. Li M.Y., Miao W.Y., Wu Q.Z., He S.J., Yan G., Yang Y., Liu J.J., Taketo M.M. and Yu, X.* (2017) A critical role of presynaptic Cadherin/Catenin/p140cap complexes in stabilizing spines and functional synapses in the neocortex. Neuron 94(6):1155-1172
12. Wang L., Li M.Y., Qu C., Miao W.Y., Yin Q, Liao J., Cao H.T., Huang M., Wang K., Zuo E., Peng G., Zhang S.X., Chen G., Li Q., Tang K., Yu Q., Li Z., Wong CCL, Xu G., Jing N., Yu X.*, and Li J*. (2017) CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development. Cell Res. 27(6):815-829
13. Wang M., Li H., Takumi T., Qiu Z., Xu X.*, Yu X.* and Bian W.J.* (2017) Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism Neurosci. Bull. 33(2):143-152
14. Zhang S.X., Duan L.H., He S.J., Zhuang G.F. and Yu X.* (2017) Phosphatidylinositol 3,4-bisphosphate regulates neurite initiation and dendrite morphogenesis via actin aggregation. Cell Res. 27(2):253-273.
15. Bian W.J., Miao W.Y., He S.J., Qiu Z. and Yu, X.* (2015) Coordinated spine pruning and maturation mediated by inter-spine competition for cadherin/catenin complexes. Cell 162(4): 808-822 [highlighted by Nat. Rev. Neurosci. 16(10):577; selected as “exceptional” by Faculty 1000]
16. Zheng J.J., Li S.J., Zhang X.D., Miao W.Y., Zhang D., Yao H. and Yu, X.* (2014) Oxytocin mediates early experience–dependent cross-modal plasticity in the sensory cortices. Nat. Neurosci. 17(3):391-399 [highlighted by same issue News and Views 17(3), 340 and by Nat. Rev. Neurosci. 15(3):139; selected as “exceptional” by Faculty 1000]
17. Xu X.*, Xu Q., Zhang Y., Zhang X., Cheng T., Wu B., Ding Y., Lu P., Zheng J., Zhang M., Qiu Z., and Yu X.* (2012) A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections. BMC Med. Genet. 13(1):75 doi:10.1186/1471- 2350-13-75
18. Peng Y.R., Zeng S.Y., Song H.L., Li M.Y., Yamada M.K., and Yu X.* (2010) Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling J. Neurosci. 30(48):16220-16231, cover story.
19. He S., Ma J., Liu N. and Yu, X.* (2010) Early enriched environment promotes neonatal GABAergic neurotransmission and accelerates synapse maturation. J. Neurosci. 30(23):7910-7916.
20. Tan Z.J., Peng Y., Song H.L. and Yu X.* (2010) N-cadherin dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth. Proc. Natl. Acad. Sci. USA 107(21):9873-9878, cover story.
21. Peng Y.R., He S., Marie H., Zeng S.Y., Ma J., Tan Z.J., Lee S., Malenka R.C.*, and Yu X.* (2009) Coordinated changes in dendritic arborization and synaptic strength during neural circuit development. Neuron 61(1):71-84. (Selected by Faculty 1000).
22. Yu X.* and Malenka R.C.* (2003) β¬-catenin is critical for dendritic morphogenesis. Nat. Neurosci. 6(11): 1169-¬1177, cover story.