| 题名： | 通过模仿红细胞柔性来扩大水凝胶微粒的循环时间 |
| 作者： | Timothy J. Merkel, Stephen W. Jones, Kevin P. Herlihy, Farrell R. Kersey, Adam R. Shields, Mary Napier, J. Christopher Luft, Huali Wu, William C. Zamboni, Andrew Z. Wang, James E. Bear, Joseph M. Desimone. |
| 单位： | Sloan–Kettering Institute for Cancer Research, Memorial Sloan–Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 |
| 出处： | Proceedings of the National Academy of Sciences,2011,(): |
| 语种： | 英文 |
| 文摘： | It has long been hypothesized that elastic modulus governs the biodistribution and circulation times of particles and cells in blood; however, this notion has never been rigorously tested. We synthesized hydrogel microparticles with tunable elasticity in the physiological range, which resemble red blood cells in size and shape, and tested their behavior in vivo. Decreasing the modulus of these particles altered their biodistribution properties, allowing them to bypass several organs, such as the lung, that entrapped their more rigid counterparts, resulting in increasingly longer circulation times well past those of conventional microparticles. An 8-fold decrease in hydrogel modulus correlated to a greater than 30-fold increase in the elimination phase half-life for these particles. These results demonstrate a critical design parameter for hydrogel microparticles. |
| 关键词： | mechanobiological mimicry; red blood cells; circulation times;hydrogel microparticles |
通过模仿红细胞柔性来扩大水凝胶微粒的循环时间
核心摘要：
题名 通过模仿红细胞柔性来扩大水凝胶微粒的循环时间 作者 Timothy J. Merkel Stephen W. Jones Kevin P. Herlihy Farrell R. Kersey A 关键词：Science