英国纽卡斯尔大学网站6月25日的消息称，该校研究人员的一项最新研究发现，Ⅱ型糖尿病患者只需将每日摄入600卡路里热量的饮食习惯坚持两个月，就可使病情得到扭转。研究称低热量饮食可减少脂肪在胰脏中的沉积，恢复胰岛素的分泌，从而缓解病情。相关论文发表在国际糖尿病学权威杂志《糖尿病学》（Diabetologia）上。

Ⅱ型糖尿病又被称为非胰岛素依赖型糖尿病，一直被认为是一种不可逆的慢性进行性疾病，目前还无法被治愈，只能通过合理的营养、适度的运动以及一些药物减轻或避免并发症的发生。其发病原因一般是患者自身无法产生足够多的胰岛素来平衡血液中糖和脂肪代谢，或是身体细胞无法对胰岛素作出反应。

参加此次研究的共有11名患有Ⅱ型糖尿病的志愿者，在研究人员和医生的指导下，他们逐渐将每日摄入的热量减少到600卡路里。经过短短一周后，志愿者早餐前空腹血糖水平就已达到正常指标。八周后，通过核磁共振成像检查，研究人员发现，这些糖尿病患者胰脏周围的脂肪水平开始下降，胰岛素的分泌也趋于正常，个别患者甚至已经可以暂时停用降糖药物。实验结束后，志愿者们恢复了正常的饮食，但研究人员建议他们仍然保持健康的饮食习惯。三个月后进行复查，参与实验的11名志愿者中有7人没有出现复发现象。

虽然此次实验的结果令人鼓舞，但研究人员告诫说，如果没有医生认可和协助，患者个人最好不要贸然采用如此严格的节食措施。

负责该项研究的英国纽卡斯尔大学教授罗伊·泰勒说，该研究表明，Ⅱ型糖尿病与体内的能量平衡存在着密切关系。如果摄入的能量超过身体所需要的，多出的部分就会在肝脏和胰脏附近累积。在这样的情况下，有一部分人就会患上Ⅱ型糖尿病。

研究人员称，虽然此次实验规模比较小，但他们仍期待着进一步的成果。下一步他们还将就为什么某些人比其他人更易患糖尿病展开研究。另外，研究人还将对此次实验的志愿者进行跟踪观察，以确定治愈效果能否持续较长的时间。（生物谷Bioon.com）

生物谷推荐原味出处：

Diabetologia    DOI 10.1007/s00125-011-2204-7

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

E. L. Lim & K. G. Hollingsworth & B. S. Aribisala & M. J. Chen & J. C. Mathers & R. Taylor

Aims/hypothesis Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake.

Methods Eleven people with type 2 diabetes (49.5±2.5 years, BMI 33.6±1.2 kg/m2, nine male and two female)

were studied before and after 1, 4 and 8 weeks of a 2.5 MJ (600 kcal)/day diet. Basal hepatic glucose output, hepatic and peripheral insulin sensitivity and beta cell function  were measured. Pancreas and liver triacylglycerol content was measured using three-point Dixon magnetic resonance imaging. An age-, sex- and weight-matched group of eight non-diabetic participants was studied.

Results After 1 week of restricted energy intake, fasting plasma glucose normalised in the diabetic group (from 9.2±0.4 to 5.9±0.4 mmol/l; p=0.003). Insulin suppression of hepatic glucose output improved from 43±4% to 74±5% (p= 0.003 vs baseline; controls 68±5%). Hepatic triacylglycerol content fell from 12.8±2.4% in the diabetic group to 2.9±0.2% by week 8 (p=0.003). The first-phase insulin response increased during the study period (0.19±0.02 to 0.46±0.07 nmol min.1 m.2; p<0.001) and approached control

Aims/hypothesis Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake.

Methods Eleven people with type 2 diabetes (49.5±2.5 years, BMI 33.6±1.2 kg/m2, nine male and two female)

were studied before and after 1, 4 and 8 weeks of a 2.5 MJ (600 kcal)/day diet. Basal hepatic glucose output, hepatic and peripheral insulin sensitivity and beta cell function were measured. Pancreas and liver triacylglycerol content was measured using three-point Dixon magnetic resonance imaging. An age-, sex- and weight-matched group of eight non-diabetic participants was studied.

Results After 1 week of restricted energy intake, fasting plasma glucose normalised in the diabetic group (from 9.2±0.4 to 5.9±0.4 mmol/l; p=0.003). Insulin suppression of hepatic glucose output improved from 43±4% to 74±5% (p= 0.003 vs baseline; controls 68±5%). Hepatic triacylglycerol content fell from 12.8±2.4% in the diabetic group to 2.9±0.2% by week 8 (p=0.003). The first-phase insulin response increased during the study period (0.19±0.02 to 0.46± 0.07 nmol min.1 m.2; p<0.001) and approached control