研究发现糖在细胞的生命周期充当重要角色(3)

The  researchers'  next  steps  are  to  examine  select  proteins  modified  by  O-GlcNAc  and  found  at  locations  important  for  various  steps  in  cell  division  to  figure  out  why  an  imbalance  of  O-GlcNAc  on  the  cells'  proteins  has  such  a  dramatic  effect  on  the  process.

The  researchers  were  funded  by  the  National  Institute  of  Child  Health  and  Human  Development,  the  National  Institute  of  Diabetes  and  Digestive  and  Kidney  Diseases  and  the  National  Cancer  Institute.

Authors  on  the  paper  are  Slawson,  Natasha  Zachara,  Keith  Vosseller,  Win  Den  Cheung,  Daniel  Lane  and  Gerald  Hart,  all  at  Johns  Hopkins  while  working  on  this  project.  Vosseller  is  now  at  Drexel  University.

O-GlcNAc  modification  of  proteins  is  detected  using  an  antibody  developed  at  Johns  Hopkins.  Under  a  licensing  agreement  between  Covance  Research  Products,  Sigma  Chemical  Company  and  The  Johns  Hopkins  University  School  of  Medicine,  Hart  receives  a  percentage  of  royalties  received  by  the  university  on  sales  of  this  antibody  (CTD  110.6).  The  terms  of  this  arrangement  are  being  managed  in  accordance  with  the  university's  conflict  of  interest  policy.

蛋白质的O位N-乙酰葡萄糖胺(O-GlcNAc)糖基化修饰是一种新近发现的广泛存在于细胞核蛋白与细胞浆蛋白的蛋白质翻译后修饰.其性质与经典的膜蛋白和分泌蛋白的糖基化修饰不同，而与蛋白质磷酸化修饰更相似。 (责任编辑：泉水)

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研究发现糖在细胞的生命周期充当重要角色(3)