ISRAEL SILMAN　Ph.D.(2)

3. Brumshtein B, Wormald MR, Silman I, Futerman AH, Sussman JL. (2006) Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease. Acta Crystallogr D Biol Crystallogr. 62(Pt 12):1458-65.

4. Esnouf RM, Hamer R, Sussman JL, Silman I, Trudgian D, Yang ZR, Prilusky J. (2006) Honing the in silico toolkit for detecting protein disorder. Acta Crystallogr D Biol Crystallogr. 62(Pt 10):1260-6. Review.

5. Banci L, Bertini I, Cusack S, de Jong RN, Heinemann U, Jones EY, Kozielski F, Maskos K, Messerschmidt A, Owens R, Perrakis A, Poterszman A, Schneider G, Siebold C, Silman I, Sixma T, Stewart-Jones G, Sussman JL, Thierry JC, Moras D. (2006) First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value. Acta Crystallogr D Biol Crystallogr. 62(Pt 10):1208-17. Review.

6. Albeck S, Alzari P, Andreini C, Banci L, Berry IM, Bertini I, Cambillau C, Canard B, Carter L, Cohen SX, Diprose JM, Dym O, Esnouf RM, Felder C, Ferron F, Guillemot F, Hamer R, Ben Jelloul M, Laskowski RA, Laurent T, Longhi S, Lopez R, Luchinat C, Malet H, Mochel T, Morris RJ, Moulinier L, Oinn T, Pajon A, Peleg Y, Perrakis A, Poch O, Prilusky J, Rachedi A, Ripp R, Rosato A, Silman I, Stuart DI, Sussman JL, Thierry JC, Thompson JD, Thornton JM, Unger T, Vaughan B, Vranken W, Watson JD, Whamond G, Henrick K. (2006) SPINE bioinformatics and data-management aspects of high-throughput structural biology. Acta Crystallogr D Biol Crystallogr. 62(Pt 10):1184-95. Review.

7. Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL. (2006) Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. J Med Chem. 49(18):5491-500.

8. Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M. (2006) Structural insights into substrate traffic and inhibition in acetylcholinesterase. EMBO J. 25(12):2746-56.

9. Sussman JL, Silman I. (2006) Shedding UV light on the phase problem. Structure. 14(4): 629-30.

10. Niu C, Xu Y, Xu Y, Luo X, Duan W, Silman I, Sussman JL, Zhu W, Chen K, Shen J, Jiang H. (2005) Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation. J Phys Chem B. 109(49):23730-8.

11. Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM. (2005) The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase. Chem Biol Interact. 157-158:153-7.

12. Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. (2005) Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. Chem Biol Interact. 157-158:247-52.

13. Xu Y, Shen J, Luo X, Silman I, Sussman JL, Chen K, Jiang H. (2003) How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations. J Am Chem Soc. 125(37):11340-9.

14. Albeck S, Burstein Y, Dym O, Jacobovitch Y, Levi N, Meged R, Michael Y, Peleg Y, Prilusky J, Schreiber G, Silman I, Unger T, Sussman JL. (2005) Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10. Acta Crystallogr D Biol Crystallogr. 61(Pt 10):1364-72.

15. Gabel F, Weik M, Masson P, Renault F, Fournier D, Brochier L, Doctor BP, Saxena A, Silman I, Zaccai G. (2005) Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study. Biophys J. 89(5):3303-11.

16. Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL. (2005) Crystal packing mediates enantioselective ligand recognition at the peripheral site of cetylcholinesterase. J Am Chem Soc. 127(31):11029-36.

17. Hasin Y, Avidan N, Bercovich D, Korczyn AD, Silman I, Beckmann JS, Sussman JL. (2005) Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. Curr Alzheimer Res. 2(2):207-18.

18. Prilusky J, Felder CE, Zeev-Ben-Mordehai T, Rydberg EH, Man O, Beckmann JS, Silman I, Sussman JL. (2005) FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded. Bioinformatics. 21(16):3435-8.

19. Silman I, Sussman JL. (2005) Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. Curr Opin Pharmacol. 5(3):293-302. Review.

20. Premkumar L, Sawkar AR, Boldin-Adamsky S, Toker L, Silman I, Kelly JW, Futerman AH, Sussman JL. (2005) X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. J Biol Chem. 280(25):23815-9.

21. Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM. (2005) The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Mol Pharmacol. 67(6):1874-81.

22. Parnas H, Slutsky I, Rashkovan G, Silman I, Wess J, Parnas I. (2005) Depolarization initiates phasic acetylcholine release by relief of a tonic block imposed by presynaptic M2 muscarinic receptors. J Neurophysiol. 93(6):3257-69.

23. reenblatt HM, Guillou C, Guenard D, Argaman A, Botti S, Badet B, Thal C, Silman I, Sussman JL. (2004) The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design. J Am Chem Soc. 126(47):15405-11.

24. Dvir H, Harel M, Bon S, Liu WQ, Vidal M, Garbay C, Sussman JL, Massoulie J, Silman I. (2004) The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. EMBO J. 23(22):4394-405.

25. Hasin Y, Avidan N, Bercovich D, Korczyn A, Silman I, Beckmann JS, Sussman JL. (2004) A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene. Hum Mutat. 24(5):408-16.

26. Gabel F, Weik M, Doctor BP, Saxena A, Fournier D, Brochier L, Renault F, Masson P, Silman I, Zaccai G. (2004) The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study. Biophys J. 86(5):3152-65.

27. Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. (2004) Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. Nat Struct Mol Biol. 11(5):412-9.

28. Futerman AH, Sussman JL, Horowitz M, Silman I, Zimran A. (2004) New directions in the treatment of Gaucher disease. Trends Pharmacol Sci. 25(3):147-51. Review.

29. Pe'er I, Felder CE, Man O, Silman I, Sussman JL, Beckmann JS. (2004) Proteomic signatures: amino acid and oligopeptide compositions differentiate among phyla. Proteins. 54(1):20-40.

30. Aharoni A, Gaidukov L, Yagur S, Toker L, Silman I, Tawfik DS. (2004) Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. Proc Natl Acad Sci U S A. 101(2):482-7.

31. Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Auld VJ, Silman I, Botti S, Sussman JL. (2003) The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded. Proteins. 53(3):758-67.

32. Greenblatt HM, Dvir H, Silman I, Sussman JL. (2003) Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease. J Mol Neurosci. 20(3):369-83. Review.

33. Millard CB, Shnyrov VL, Newstead S, Shin I, Roth E, Silman I, Weiner L. (2003) Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones. Protein Sci. 12(10):2337-47.

34. Dvir H, Harel M, McCarthy AA, Toker L, Silman I, Futerman AH, Sussman JL. (2003) X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease. EMBO Rep. 4(7):704-9.

35. Zeev-Ben-Mordehai T, Silman I, Sussman JL. (2003) Acetylcholinesterase in motion: visualizing conformational changes in crystal structures by a morphing procedure. Biopolymers. 68(3):395-406.

36. Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. (2003) Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. J Am Chem Soc. 125(2):363-73.

37. Weik M, Berges J, Raves ML, Gros P, McSweeney S, Silman I, Sussman JL, Houee-Levin C, Ravelli RB. (2002) Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation. J Synchrotron Radiat. 9(Pt 6):342-6. (责任编辑：泉水)

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