2006年10月17日传来消息，历经60余名候选人的严格筛选，全球最具影响力的综合性学术期刊之一——《美国国家科学院院刊》（Proceedings of the National Academy of Sciences，简称PNAS）终于迎来新任总编（Editor-in-Chief）：Randy Schekman。Schekman教授来自美国顶尖学府加州大学伯克利分校（该校在最新美国大学生物科学排名中与哈佛大学、麻省理工学院并列第二）。

Randy Schekman毕业于斯坦福大学，获生物化学博士学位，随后在加州大学圣地亚哥分校从事博士后研究。目前他兼任加州大学伯克利分校细胞与发育生物学系教授及霍华德·休斯医学研究所（HHMI）研究员。其主要研究方向为酿酒酵母细胞内蛋白运输的调控机制，尤其聚焦于分泌过程及细胞器中的蛋白组装。其他研究领域还包括酶学、遗传学和电子显微学。凭借在囊泡运输领域的开创性贡献，Schekman于2013年与James Rothman、Thomas Südhof共同荣获诺贝尔生理学或医学奖。

PNAS是全世界被引次数最高的综合性学科丛书之一，自1914年创刊以来，主要发表前沿研究报告（Cutting-edge Research Reports）、学术评论（Commentaries）、学科回顾（Reviews）、前瞻性文章（Perspectives）、学术论文（Colloquium Papers）以及美国国家科学学会的学术动态。内容涵盖生物学、自然科学和社会科学等学科，每两周出版一期印刷版。2004年，PNAS的SCI影响因子为10.452。网络版PNAS（PNAS Online）于1997年1月上线，提供1990年以来所有文献的摘要、全文、图表、公式及参考文献。

主要著作（代表性论文）（部分）：

1. Simeon A. Boyadiev et al. Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal ER-to-Golgi trafficking. Nature Genetics (2006), in press.

2. Wang, C.W. et al. Exomer: a coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. J. Cell Biol. (2006), in press.

3. Sanchatjate, S. & Schekman, R. Chs5/6 Complex: A Multi-Protein Complex That Interacts with and Conveys Chitin Synthase III from the Trans-Golgi Network to the Cell Surface. Mol. Biol. Cell 2006 Jul 19.

4. Lee, M.C.S. et al. Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. Cell 122, 605-617 (2005).

5. Miller, E.A. et al. ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p. Mol. Biol. Cell 16, 3719-3726 (2005).

6. Fromme, J.C. & Schekman, R. COPII-coated vesicles: flexible enough for large cargo? Curr. Opin. Cell Biol. 17, 345-352 (2005).

7. Schekman, R. Peroxisomes: another branch of the secretory pathway? Cell 122, 1-2 (2005).

8. Futai, E. & Schekman, R. Purification and functional properties of Sec12 GEF. Meth Enzymol. 404, 74-82 (2005).

9. Wickner, W. & Schekman, R. Protein translocation across biological membranes. Science 310, 1452-1456 (2005).

10. Schekman, R. Membrane traffic in landmark papers in yeast biology. Landmark Papers (Eds. P. Linder, D. Shore and M. Hall) pgs. 243-252 (2005).

11. Kim, J. et al. Uncoupled packaging of amyloid precursor protein and presenilin 1 into COPII vesicles. J. Biol. Chem. 280, 7758-7768 (2004).

12. Sun, Y. et al. Interaction of Sla2p's ANTH domain with PtdIns(4,5)P2 is important for actin-dependent endocytic internalization. Mol. Biol. Cell 16, 717-730 (2004).

13. Malkus, P. et al. Role of Vma21p in assembly and transport of the yeast vacuolar ATPase. Mol. Biol. Cell 15, 5075-5091 (2004).

14. Futai, E. et al. GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes. EMBO J. 23, 4286-4296 (2004).

15. Schekman, R. A channel for protein waste. Nature 429, 817-818 (2004).

16. Schekman, R. Merging cultures in the study of membrane traffic. Nature Cell Biol. 6, 483-486 (2004).

17. Lee, M.C.S. et al. Bi-directional protein transport between the ER and Golgi. Annu. Rev. Cell Dev. Biol. 20, 87-123 (2004).

18. Kim, J. & Schekman, R. The ins and outs of presenilin 1 membrane topology. PNAS 101, 905-906 (2004).

19. Lee, M.C.S. & Schekman, R. BAR domains go on a bender. Science 303, 479-480 (2004).

20. Schekman, R. & Novick, P. 23 genes, 23 years later. Cell S116, S13-S15 (2004).

21. Antonny, B. et al. Self-assembly of minimal COPII cages. EMBO Reports 4, 419-424 (2003).

22. Valdivia, R. & Schekman, R. The yeast Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane. Proc. Natl. Acad. Sci. USA 100, 10287-10292 (2003).

23. Miller, E. et al. Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell 114, 1-20 (2003).

24. Harsay, E. & Schekman, R. A subset of yeast vacuolar protein sorting mutants are blocked in one branch of the exocytic pathway. J. Cell Biol. 156, 271-286 (2002).

25. Valdivia, R.H. et al. The yeast clathrin adaptor protein complex-1 is required for the efficient retention of a subset of late-Golgi membrane proteins. Dev. Cell 2, 283-294 (2002).

26. Lee, M.C.S. et al. Ceramide biosynthesis is required for the formation of oligomeric H+-ATPase, Pma1p, in the yeast endoplasmic reticulum. J. Biol. Chem. 277, 22395-22401 (2002).

27. Shimoni, Y. & Schekman, R. Vesicle budding from the ER. Meth. Enzymol. 351, 258-278 (2002).

28. Supek, F. et al. Sec16p potentiates the action of COPII proteins to bud transport vesicles. J. Cell Biol. 158, 1029-1038 (2002).

29. Miller, E. et al. Cargo selection into COPII vesicles is driven by the Sec24p subunit. EMBO J. 21, 6105-6113 (2002).

30. Schekman, R. SEC mutants and the secretory apparatus. Nature Medicine 8, 1055-1058 (2002).

31. Deloche, O. & Schekman, R.W. Vps10p cycles between the TGN and the late endosome via the plasma membrane in clathrin mutants. Mol. Biol. Cell 13, 4296-4307 (2002).

32. Malkus, P. et al. Concentrative sorting of secretory cargo proteins into COPII-coated vesicles. J. Cell Biol. 159, 915-921 (2002).

33. Deloche O et al. Vps10p Transport from the trans-Golgi Network to the Endosome Is Mediated by Clathrin-coated Vesicles. Mol Biol Cell 12, 475-485 (2001).

34. Spang, A. et al. The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulum. Mol. Biol. Cell 12, 1035-1045 (2001).

35. Antonny, B. et al. Dynamics of the COPII coat with GTP and stable analogues. Nature Cell Biol. 3, 531-537 (2001).

36. Antonny, B. & Schekman, R. ER export: Public transportation by the COPII coach. Curr. Opin. Cell Biol. 13, 438-443 (2001).

37. Lederkremer, G.Z. et al. Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. PNAS 98, 10704-10709 (2001).

38. Matsuoka, K. et al. Surface structure of the COPII-coated vesicle. PNAS 98, 13705-13709 (2001).