40. Pende, M., S.C. Kozma, M. Jacquet, V. Oorschot, R. Burcelin, Y. Le Marchand-Brustel, J. Klumperman, B. Thorens, and G. Thomas. 2000. Hypoinsulinaemia, glucose intolerance and diminished b-cell size in S6K1-deficient mice. Nature 408, 994-997.

41. Van Kerkhof, P., M. Sachse, J. Klumperman, and G. Strous. 2001. Growth hormone receptor ubiquitination coincides with recruitment to clathrin-coated membrane domains. J. Biol. Chem. 27, 3778-3784.

42. Smit AB, NI Syed, D Schaap, J. van Minnen, J. Klumperman, KS Kits, H. Lodder, RC van der Schors, R. van Elk, B. Sorgedrager, K. Brejc, TK Sixma, WP Geraerts. 2001. A glia-derived acetylcholine-binding protein that modulates synaptic transmission. Nature 411, 261-268. (impact factor

43. de Wit, H., Y. Lichtenstein, R.B. Kelly, H.J. Geuze, J. Klumperman*, and P. van der Sluijs*. 2001. Rab4 regulates formation of synaptic-like microvesicles and constitutive recycling vesicles from early endosomes in PC12 cells. Mol Biol Cell. 12 (11):3703-3715. *with equal contributions

44. Sachse, M., P. van Kerkhof, G. Strous, and J. Klumperman. 2001. The ubiquitin-dependent endocytosis motif is required for the incorporation of growth hormone receptor in the forming clathrin-coated pit. J. Cell Science 114 (21):3943-3952.

45. Oprins, A, C. Rabouille, G. Posthuma, J. Klumperman, H.J. Geuze and J.W. Slot. 2001. The ER to Golgi interface is the major site of secretory protein concentration in exocrine pancreatic cells. Traffic 2:831-838.

46. Sprong, H., S. Degroote, T. Claessens, J. van Drunen, V. Oorschot, B.H.. Westerink, Y. Hirabayashi, J. Klumperman, P. van der Sluijs, and G. van Meer. 2001 Glycosphingolipids are required for sorting melanosomal proteins in the Golgi complex. J Cell Biol. 155 (3):369-380.

47. Klopfenstein DR, J. Klumperman, A. Lustig, RA Kammerer, V. Oorschot, and HP Hauri.  2001. Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment. J Cell Biol. 153 (6):1287-1300.

48. van Kerkhof P, CM dos Santos, M. Sachse, J. Klumperman, G. Bu, and GJ Strous. 2001. Proteasome Inhibitors Block a Late Step in Lysosomal Transport of Selected Membrane but not Soluble Proteins. Mol Biol Cell. 12 (8):2556-2566.

49. Martinez-Menarguez, J.A., R. Prekeris, V. Oorschot, RH Scheller, JW Slot, HJ Geuze, and J. Klumperman. 2001. Peri-Golgi vesicles contain retrograde but not anterograde proteins consistent with the cisternal progression model of intra-Golgi transport. J Cell Biol. 155: 1213-1224.

50. Sachse, M., G. Ramm, G. Strous, and J. Klumperman. 2002. Endosomes: multipurpose designs for integrating housekeeping and specialized tasks. [Review]. Histochem. and Cell Biol. 117:91-104

51. Sachse M., S. Urbé, V. Oorschot, G. Strous, and J. Klumperman. 2002. Bi-layered clathrin coats on endosomal vacuoles are involved in protein sorting towards lysosomes. Molc. Biol. Cell. 13:1313-1328.

52. Mohrmann K., L. Gerez, V. Oorschot, J. Klumperman and P. van der Sluijs. 2002. Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle. J. Biol. Chem. 277:32029-3325.

53. Oorschot V., de Wit, H., Annaert, W and Klumperman, J. 2002. A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation. J. Histochem. Cytochem 50:1067-1080.

54. Andrieux A, Salin PA, Vernet M, Kujala P, Baratier J, Gory-Faure S, Bosc C, Pointu H, Proietto D, Schweitzer A, Denarier E, Klumperman J, Job D. 2002. The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders. Genes Dev. 16:2350-2364.

55. Deneka M, Neeft M, Popa I, van Oort M, Sprong H, Oorschot V, Klumperman J, Schu P, van der Sluijs P. 2003. Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes. EMBO J. 22(11):2645-2657.

56. Rechards, M., Xia, W., Oorschot, VM, Selkoe DJ and J. Klumperman. 2003. Presenilin-1 Exists in Both Pre- and Post-Golgi Compartments and Recycles Via COPI-Coated Membranes. Traffic 4(8):553-565.

57. Urbé, S., Sachse, M., Row, P.E., Preisinger, C., Barr, F.A., Strous, G., Klumperman, J., and Clague, M.J. 2003. The UIM domain of Hrs couples receptor sorting to vesicle formation. J Cell Sci. 116:4169-4179.

58. A.J. Koster and J. Klumperman. Electron microscopy: stretching the resolution limits of imaging (Review). 2003. Nature Review Mol Cell Biology/Nature Cell Biology. Supplement September issue:ss6-ss10 (IF = 21/15)

59. Hendriks G, Koudijs M, Van Balkom BW, Oorschot V, Klumperman J, Deen PM, Van Der Sluijs P. 2004. Glycosylation is important for cell surface expression of the water channel aquaporin-2, but is not essential for tetramerization in the endoplasmic reticulum. J Biol Chem. 279:2975-2983. Epub 2003 Oct 30.

60. Sachse, M., Strous, G.J. and J. Klumperman. 2004. ATPase deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles. J. Cell Science. 117:1699-1708. Epub 2004 Mar 09.

61. Bouwman, J., Maia, A.S., Camoletto, P., Posthuma, G., Roubos, E.W., Oorschot, V.M.J., Klumperman, J. and M. Verhage. 2004. Quantification of synapse formation and maintenance in vivo in the absence of synaptic release. Neuroscience 126:115-126.

62. Junutala, J.R., De Mazière, A., Peden, A.A., Ervin, K.E., Advani, R.J., van Dijk, S.M., Klumperman, J. and R.H. Scheller. 2004.  Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. Molc. Biol. Cell. 15:2218-2229.

63. Griffith, G. and J. Klumperman. 2004. Membranes and sorting. Current Opinion in Cell Biology 16:341-342. (review on invitation).

64. Peden, A.A., Oorschot, V., Hesser, B., Austin, C.D., Scheller, R.H. and J. Klumperman. 2004. Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. J. Cell Biol. 164:1065-1076.

65. Esselens, C., Oorschot, V., Baert, V., Raemaekers, T., Spittaels, K., Serneels, L., Zheng, H., Saftig, P., De Strooper, B., Klumperman, J. and W. Annaert. 2004. Presenilin 1 deficiency affects the Telencephalin-mediated autophagic degradative pathway in hippocampal neurons. J. Cell Biol. 27;166(7):1041-54.

66. Cerny, J., Feng, Y., Yu, A., Miyake, K., Borgonovo, B., Klumperman, J., Meldolesie, J., McNeil, P.L. and T. Kirchhausen. 2004. The small chemical Vacuolin-1 inhibits Ca++-dependent lysosomal exocytosis but not cell wound healing. EMBO J. 5(9):883-888.

67. Carlton, J., Bujny,. M., Peter, B.J., Oorschot, V.M.J., Rutherford, A., Mellor, H., Klumperman, J., McMahon, H., and P.J. Cullen. 2004. Sorting nexin-1 mediates tubular endosome-to-TGN transport through co-incidence sensing of high curvature membranes and 3-phosphoinositides. Current Biology. 26;14(20):1791-800.

68. Austin, C. D., De Maziere, A. M., Pisacane, P. I., van Dijk, S. M., Eigenbrot, C., Sliwkowski, M. X., Klumperman, J. & Scheller, R. H. 2004. Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics Trastuzumab and Geldanamycin. Mol Biol Cell 15, 5268-82.

69 Cavalli, V., Kujala, P., Klumperman, J.  and L.S.B. Goldstein. 2005.  Sunday Driver links axonal transport to damage signaling J Cell Biol. 168(5):775-787.

70. Rabouille, C. and J. Klumperman. 2005. The maturing role of COPI vesicles in intra-Golgi transport. Nature Reviews Molecular Cell Biology 6:812-817 (Review on invitation).

71. van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman, J, and G. Bu. 2005. Sorting nexin 17 facilitates LRP recycling in the early endosome. EMBO J 24(16):2851-2861.

72. Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ. 2005. Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J Cell Sci. 118 (Pt 19):4527-4239.

73. Zeuschner D, Geerts WJC, van Donselaar E, Humbel. B., Slot JW, Koster AJ, and J. Klumperman. 2006. Immuno-electron tomography reveals the existence of free COPII-coated transport carriers. Nature Cell Biol. Epub March 16.

74. Rechards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J. 2006 Presenilin-1-mediated retention of APP Derivatives in early biosynthetic compartments. Traffic 7(3):354-364.