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Mutations in the LRRK2 gene, a key protein in the brain associated with Parkinson's disease (PD), have been found to disrupt the normal growth and branching of neurons, leading to their death. This discovery, published in the journal Neuron, could pave the way for new animal models and treatments for PD.

The study, conducted by researchers at Columbia University, revealed that mutant forms of the LRRK2 protein exhibit increased kinase activity, which in turn hampers neuronal growth and survival. These findings not only provide insight into the early pathological features of PD but also suggest potential therapeutic targets.

Funding for the research was provided by the American Parkinson's Disease Association, the NIH, NINDS, NIA, and various foundations. The research team includes David MacLeod, Julia Dowman, Rachel Hammond, Thomas Leete, Keiichi Inoue, and Asa Abeliovich.

Contact: Heidi Hardman
Cell Press
DOI: 10.1016/j.neuron.2006.10.008
URL: http://www.neuron.org/