Interneuronal Migration Sans Reelin

This week, Pla et al. argue that interneurons, unlike cortical projection neurons, migrate to their cortex locations without Reelin, the secreted product of Cajal-Retzius cells. Cortical interneurons originate in the median ganglionic eminence(MGE), migrate tangentially to cortex, and then radially to their final laminar position. The authors report that mice lacking Dab1, the intracellular adaptor protein necessary for Reelin signaling, had impaired laminar distribution, but the tangential migration was normal. To study the laminar migration, the authors used microtransplantation to graft embryonic day 12.5 (E12.5) or E15 interneurons into the MGE of E12 or E15 hosts. The resulting lamination depended on the age of the grafted interneurons and to a lesser extent the age of the host, seemingly incompatible with direct Reelin signaling. Grafts of Dab1-/- neurons into wild-type hosts also displayed normal lamination. Because interneurons reach their final position after projection neurons, the authors suggest that they are guided by cues from the projection neurons rather than Reelin.

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Tips from The Journal of Neuroscience
Ramon Pla, V韈tor Borrell, Nuria Flames, and Oscar Mar韓

Contact: Sara Harris
Society for Neuroscience
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Interneuronal Migration Sans Reelin